ID Q6MGB2_RAT Unreviewed; 1617 AA. AC Q6MGB2; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 29-MAY-2024, entry version 162. DE SubName: Full=Collagen type XI alpha 2 chain {ECO:0000313|Ensembl:ENSRNOP00000073041.1}; DE SubName: Full=Procollagen, type XI, alpha 2 {ECO:0000313|EMBL:CAE83934.1}; GN Name=Col11a2 {ECO:0000313|EMBL:CAE83934.1, GN ECO:0000313|Ensembl:ENSRNOP00000073041.1, ECO:0000313|RGD:2373}; GN Synonyms=AA926063 {ECO:0000313|RGD:2373}, B3galt4 GN {ECO:0000313|RGD:2373}, Cdk2ap1-ps1 {ECO:0000313|RGD:2373}, Daxx GN {ECO:0000313|RGD:2373}, Hsd17b8 {ECO:0000313|RGD:2373}, Kifc1 GN {ECO:0000313|RGD:2373}, LOC224733l-1 {ECO:0000313|RGD:2373}, GN LOC224733l-2 {ECO:0000313|RGD:2373}, Phf1 {ECO:0000313|RGD:2373}, GN Rps25-ps1 {ECO:0000313|RGD:2373}, RT1-A1 {ECO:0000313|RGD:2373}, GN RT1-A2 {ECO:0000313|RGD:2373}, RT1-A3 {ECO:0000313|RGD:2373}, RT1-DOa GN {ECO:0000313|RGD:2373}, RT1-Hb {ECO:0000313|RGD:2373}, RT1-Ke4 GN {ECO:0000313|RGD:2373}, Rxrb {ECO:0000313|RGD:2373}, Sacm2l-ps1 GN {ECO:0000313|RGD:2373}, Sacm2l-ps2 {ECO:0000313|RGD:2373}, Sec61-ps GN {ECO:0000313|RGD:2373}, Syngap1 {ECO:0000313|RGD:2373}; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116 {ECO:0000313|EMBL:CAE83934.1}; RN [1] {ECO:0000313|EMBL:CAE83934.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83934.1}; RA Boehm S., Borzym K., Gelling S., Gimmel V., Heitmann K., Kosiura A., RA Lang N., Lehrack S., Thiel J., Sontag M., Hurt P., Himmelbauer H., RA Sudbrak R., Reinhardt R.; RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:CAE83934.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Brown Norway {ECO:0000313|EMBL:CAE83934.1}; RX PubMed=15060004; DOI=10.1101/gr.1987704; RA Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., RA Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.; RT "The genomic sequence and comparative analysis of the rat major RT histocompatibility complex."; RL Genome Res. 14:631-639(2004). RN [3] {ECO:0000313|Ensembl:ENSRNOP00000073041.1, ECO:0000313|Proteomes:UP000002494} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073041.1, RC ECO:0000313|Proteomes:UP000002494}; RX PubMed=15057822; DOI=10.1038/nature02426; RG Rat Genome Sequencing Project Consortium; RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., RA Mockrin S., Collins F.S.; RT "Genome sequence of the Brown Norway rat yields insights into mammalian RT evolution."; RL Nature 428:493-521(2004). RN [4] {ECO:0000313|Ensembl:ENSRNOP00000073041.1} RP IDENTIFICATION. RC STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000073041.1}; RG Ensembl; RL Submitted (FEB-2024) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX883042; CAE83934.1; -; Genomic_DNA. DR RefSeq; NP_997693.1; NM_212528.1. DR PaxDb; 10116-ENSRNOP00000048846; -. DR Ensembl; ENSRNOT00000085547.2; ENSRNOP00000073041.1; ENSRNOG00000000463.7. DR GeneID; 294279; -. DR KEGG; rno:294279; -. DR UCSC; RGD:2373; rat. DR AGR; RGD:2373; -. DR CTD; 1302; -. DR RGD; 2373; Col11a2. DR eggNOG; KOG3544; Eukaryota. DR GeneTree; ENSGT00940000159762; -. DR HOGENOM; CLU_001074_2_1_1; -. DR OrthoDB; 2970887at2759; -. DR Proteomes; UP000002494; Chromosome 20. DR Bgee; ENSRNOG00000000463; Expressed in frontal cortex and 19 other cell types or tissues. DR GO; GO:0005581; C:collagen trimer; ISO:RGD. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central. DR GO; GO:0005615; C:extracellular space; IBA:GO_Central. DR GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IBA:GO_Central. DR GO; GO:0008201; F:heparin binding; IBA:GO_Central. DR GO; GO:0051216; P:cartilage development; ISO:RGD. DR GO; GO:0002062; P:chondrocyte differentiation; ISO:RGD. DR GO; GO:0030199; P:collagen fibril organization; ISO:RGD. DR GO; GO:0001649; P:osteoblast differentiation; IEP:RGD. DR GO; GO:0060021; P:roof of mouth development; ISO:RGD. DR GO; GO:0007605; P:sensory perception of sound; ISO:RGD. DR GO; GO:0001501; P:skeletal system development; ISO:RGD. DR GO; GO:0048705; P:skeletal system morphogenesis; ISO:RGD. DR GO; GO:0060023; P:soft palate development; ISO:RGD. DR GO; GO:0001894; P:tissue homeostasis; ISO:RGD. DR CDD; cd00110; LamG; 1. DR Gene3D; 2.60.120.1000; -; 1. DR Gene3D; 2.60.120.200; -; 1. DR InterPro; IPR008160; Collagen. DR InterPro; IPR013320; ConA-like_dom_sf. DR InterPro; IPR000885; Fib_collagen_C. DR InterPro; IPR001791; Laminin_G. DR InterPro; IPR048287; TSPN-like_N. DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1. DR PANTHER; PTHR24023:SF509; COLLAGEN ALPHA-2(XI) CHAIN; 1. DR Pfam; PF01410; COLFI; 2. DR Pfam; PF01391; Collagen; 6. DR Pfam; PF02210; Laminin_G_2; 1. DR SMART; SM00038; COLFI; 1. DR SMART; SM00282; LamG; 1. DR SMART; SM00210; TSPN; 1. DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1. DR PROSITE; PS51461; NC1_FIB; 1. PE 4: Predicted; KW Collagen {ECO:0000256|ARBA:ARBA00023119, ECO:0000313|EMBL:CAE83934.1}; KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530}; KW Reference proteome {ECO:0000313|Proteomes:UP000002494}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Secreted {ECO:0000256|ARBA:ARBA00022530}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..1617 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014106449" FT DOMAIN 1422..1616 FT /note="Fibrillar collagen NC1" FT /evidence="ECO:0000259|PROSITE:PS51461" FT REGION 228..277 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 290..379 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 399..1419 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 228..257 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 528..547 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 626..643 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 773..799 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1074..1088 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1617 AA; 158956 MW; BEB9203E347F568A CRC64; MERCSRCHRL LLLLPLVLGL SAAPGWAGAP SVDVLRALRF PSLPDGVRKS KGVCPADVAY RVARPAQLSA PTRQLFPGGF PKDFSLLTVV RTRSGLQAPL LTLYSAQGVQ QLGLELGRPV RFLYEDQRGR PQASAQPIFR GLSLADGKWH HVAVAVKGQS VTLIVDCKKR VTRPLPRSVH PVLDTHGVVI FGAHVLDDEV FEGDVQELLI VPGVQAAYQS CGQKDLECER EQRDGPQTQK PHRAQRSPKK EPARLHKPQN QEPQQQYPTP GEEEGVLESS LLPSLEEVAH GPRGLKGEKG EPAVLEPGMF VEGPPGPEGP AGLAGPPGIQ GNPGPVGDPG ERGPPGRAGL PGSDGPPGPP GTSLMLPFRF GSSGGDKGPV VAAQEAQAQA ILQQARLALR GPPGPMGYTG RPGPLGQPGS PGLKGESGDL GPQGPRGPQG LTGPPGKAGR RGRAGADGAR GMPGEPGVKG DRGFDGLPGL PGEKGQRGDT GAQGLPGPPG EDGERGDDGE IGPRGLPGES GPRGLLGPKG PPGIPGPPGP QGEPGPPGQQ GTPGTQGLPG PQGAIGPHGE KGPRGKPGLP GMPGSDGLPG HPGKEGPPGT KGNQGPSGPQ GPLGYPGPRG VKGVDGIRGL KGHKGEKGED GFPGFKGDIG VKGDRGEVGV PGSRGEDGPE GPKGRTGPTG DPGPTGLMGE KGKLGVPGLP GYPGRQGPKG SLGFPGFPGA SGEKGARGLS GKSGPRGERG PTGPRGQRGP RGATGKSGAK GTSGGDGPHG PPGERGLPGP QGPNGFPGPK GPPGPAGKDG LPGHPGQRGE VGFQGKTGPP GPPGVVGPQG AAGESGPMGE RGHPGPPGPP GEQGLPGTAG KDGTKGDPGP PGAPGKDGPA GLRGFPGERG LPGTAGGPGL KGNEGPAGPP GPAGSPGERG AAGSGGPIGP PGRPGPQGPP GAAGEKGVPG EKGPIGPTGR DGVQGPVGLP GPAGPPGVAG EDGDKGEVGD PGQKGTKGNK GEHGPPGPPG PIGPVGQPGA AGADGEPGAR GPQGHFGAKG DEGTRGFNGP PGPIGLQGLP GPFGEKGETG DVGPMGPPGP PGPRGPAGPN GADGPQGPPG GVGNLGPPGE KGEPGESGSP GVQGEPGVKG PRGERGEKGE SGQAGEAGPP GPKGPTGDDG PKGNPGPVGF PGDPGPPGEA GPRGQDGAKG SQGEDGEPGQ PGSPGPTGEN GPPGPLGKRG DPGAVGAPGK TGPVGPAGPA GKPGPDGLRG LPGSVGQQGR PGATGQAGPP GPVGPPGLPG LRGDAGAKGE KGHPGLIGLI GPTGEQGEKG DRGLPGPQGS PGQKGETGIP GASGPIGPGG PPGLPGPSGP KGAKGATGPA GPKGEKGVQG PPGHPGPPGE VIQPLPIQMP KKTRRSVDGS KLMQDEEATP TGGAPGSPAG LEEIFGSLDS LREEIEQMRR PTGTQDSPAR TCQDLKLCHP ELPDGEYWVD PNQGCARDAF RVFCNFTAGG ETCVTPRDDV TQFSYVDSEG SPVGVVQLTF LRLLSVSAHQ DVSYPCSGVS QDGPLKLRGA NEDELSPETS PYVKEFRDGC QTQQGRTVLE VRTPVLEQLP VLDASFSDLG APTRRGGVLL GPVCFMG //