ID Q6MD64 PRELIMINARY; PRT; 920 AA. AC Q6MD64; DT 05-JUL-2004 (TrEMBLrel. 27, Created) DT 05-JUL-2004 (TrEMBLrel. 27, Last sequence update) DT 05-JUL-2004 (TrEMBLrel. 27, Last annotation update) DE Putative translation initiation factor IF-2. GN OrderedLocusNames=pc0761; OS Parachlamydia sp. (strain UWE25) (subsp. Acanthamoeba sp.). OC Bacteria; Chlamydiae; Chlamydiales; Parachlamydiaceae; Parachlamydia. OX NCBI_TaxID=264201; RN [1] RP SEQUENCE FROM N.A. RA Horn M., Collingro A., Schmitz-Esser S., Beier C.L., Purkhold U., RA Fartmann B., Brandt P., Nyakatura G.J., Droege M., Frishman D., RA Rattei T., Mewes H.-W., Wagner M.; RT "Genome sequence of an amoeba symbiont and its use for reconstructing RT the evolutionary history of chlamydiae."; RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: One of the essential components for the initiation of CC protein synthesis. Protects formylmethionyl-tRNA from spontaneous CC hydrolysis and promotes its binding to the 30S ribosomal subunits. CC Also involved in the hydrolysis of GTP during the formation of the CC 70S ribosomal complex (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- SIMILARITY: Belongs to the IF-2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX908798; CAF23485.1; -. DR GO; GO:0005525; F:GTP binding; IEA. DR GO; GO:0003743; F:translation initiation factor activity; IEA. DR GO; GO:0006412; P:protein biosynthesis; IEA. DR GO; GO:0006413; P:translational initiation; IEA. DR InterPro; IPR004161; EFTU_D2. DR InterPro; IPR000886; ER_target_S. DR InterPro; IPR000178; IF2. DR InterPro; IPR006847; IF2_N. DR InterPro; IPR000795; ProtSyn_GTPbind. DR InterPro; IPR005225; Small_GTP. DR InterPro; IPR009000; Translat_factor. DR Pfam; PF00009; GTP_EFTU; 1. DR Pfam; PF03144; GTP_EFTU_D2; 2. DR Pfam; PF04760; IF2_N; 1. DR ProDom; PD186100; IF2; 1. DR TIGRFAMs; TIGR00487; IF-2; 1. DR TIGRFAMs; TIGR00231; small_GTP; 1. DR PROSITE; PS00014; ER_TARGET; UNKNOWN_1. DR PROSITE; PS01176; IF2; 1. KW Complete proteome; GTP-binding; Initiation factor; KW Protein biosynthesis. SQ SEQUENCE 920 AA; 101782 MW; 67B581DDB0A94631 CRC64; MAKNLKLNIK NAQIAEAINL SGLKSKLAKK KEEESTQKSS AAKSTSKTTK TEVEELPKEE APRIRARSKS AFAEAPADQS SKEITEEIKT SQDEESISRE AAKVIEEKSR MKTSAEIRQE IFGEELSQAP SKDSSQELEF AEKIKTNETK PTTFIEPTIA SPAPAEPKSL VEDKTSITHV YQNQKRDIPI RESLPPQEKL GPTGKHMRDF IKPKPQPERV SRPLEANNSN QKEVSEANKE KLDKNKIKPK SKGFEEPKVL TADDDARKGL KSPKFKEFKD IKPARKPETR QFDARDRQGL RTSDEDQHWR KKKNKQRQNI QEDTTIRPTS LKVRLPISIK DLASEMKLKA SQLVGKLFLQ GIVVTLNDLL EDETTAQLLG QEFGCEITID TAEEKRIQIT DKSIREELQQ SPTDQLQLRP PVVAFMGHVD HGKTSLIDAI RKSNRAAGEA GAITQHIGAF RCHTTVGDIA ILDTPGHEAF SAMRARGADV TDIVVLVVAG DEGLRQQSIE AIQHARAANV IIVVAINKCD KPNFNPDNVY RQLAEQNLLP EPWGGQTITV NCSAVTGEGI PELLEMLALQ AEVLELRANP SMRARGTVLE SEMHKGLGSV ATILVQNGTL KRGDALVFGL LWGRVKTMHD EYGKELQEAG PSTPVEITGL SGLPEAGQEF IVVKNEKEAR EIANVRSEGA RQNTFMLQQK KKVSMENMLQ QASATGKKML NIVLRADVQG SLEALKVALL KIESDKADLN IIFNGVGEVS ESDVQLAAAS KAIVLGFHTQ IESHAEALVK QLGVQVRLHN IIYHAIDDIK VLMAGLLEKI AQETEKGKAI VKATFKSSQA GIIAGCQVIE GSIHRNNYVR LKRGQEVIWK GTISSLKRVK EDVREVQKGI ECGILLNNFT DILEGDIIEA YDITYISQEL //