ID KR511_HUMAN Reviewed; 156 AA. AC Q6L8G4; DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 08-NOV-2023, entry version 112. DE RecName: Full=Keratin-associated protein 5-11; DE AltName: Full=Keratin-associated protein 5.11; DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.11; GN Name=KRTAP5-11; Synonyms=KAP5.11, KRTAP5.11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Hair root; RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074; RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., RA Shimizu N.; RT "Identification of two novel clusters of ultrahigh-sulfur keratin- RT associated protein genes on human chromosome 11."; RL Biochem. Biophys. Res. Commun. 318:655-664(2004). CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated protein (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins. CC -!- SUBUNIT: Interacts with hair keratins. CC -!- INTERACTION: CC Q6L8G4; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11993296, EBI-744545; CC Q6L8G4; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11993296, EBI-713677; CC Q6L8G4; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11993296, EBI-10192698; CC Q6L8G4; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11993296, EBI-3867333; CC Q6L8G4; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-11993296, EBI-11956087; CC Q6L8G4; O76003: GLRX3; NbExp=3; IntAct=EBI-11993296, EBI-374781; CC Q6L8G4; Q9H8Y8: GORASP2; NbExp=5; IntAct=EBI-11993296, EBI-739467; CC Q6L8G4; P49639: HOXA1; NbExp=5; IntAct=EBI-11993296, EBI-740785; CC Q6L8G4; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11993296, EBI-11959885; CC Q6L8G4; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11993296, EBI-11749135; CC Q6L8G4; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-11993296, EBI-11741292; CC Q6L8G4; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11993296, EBI-12012928; CC Q6L8G4; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11993296, EBI-10172290; CC Q6L8G4; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11993296, EBI-10171774; CC Q6L8G4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11993296, EBI-10172052; CC Q6L8G4; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11993296, EBI-1052037; CC Q6L8G4; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-11993296, EBI-10241252; CC Q6L8G4; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-11993296, EBI-11992140; CC Q6L8G4; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11993296, EBI-11988175; CC Q6L8G4; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11993296, EBI-14065470; CC Q6L8G4; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11993296, EBI-11958132; CC Q6L8G4; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11993296, EBI-11987425; CC Q6L8G4; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11993296, EBI-3958099; CC Q6L8G4; Q9BYQ4: KRTAP9-2; NbExp=5; IntAct=EBI-11993296, EBI-1044640; CC Q6L8G4; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11993296, EBI-1043191; CC Q6L8G4; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-11993296, EBI-11958364; CC Q6L8G4; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11993296, EBI-11962058; CC Q6L8G4; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11993296, EBI-10245913; CC Q6L8G4; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11993296, EBI-12224199; CC Q6L8G4; Q5T752: LCE1D; NbExp=7; IntAct=EBI-11993296, EBI-11741311; CC Q6L8G4; Q5T753: LCE1E; NbExp=4; IntAct=EBI-11993296, EBI-11955335; CC Q6L8G4; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11993296, EBI-11958008; CC Q6L8G4; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11993296, EBI-11973993; CC Q6L8G4; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-11993296, EBI-9394625; CC Q6L8G4; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11993296, EBI-11974495; CC Q6L8G4; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-11993296, EBI-10245291; CC Q6L8G4; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-11993296, EBI-10245456; CC Q6L8G4; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11993296, EBI-10246358; CC Q6L8G4; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11993296, EBI-11955689; CC Q6L8G4; Q5T871: LELP1; NbExp=3; IntAct=EBI-11993296, EBI-18115868; CC Q6L8G4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11993296, EBI-16439278; CC Q6L8G4; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-11993296, EBI-12106440; CC Q6L8G4; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11993296, EBI-22310682; CC Q6L8G4; Q92570: NR4A3; NbExp=3; IntAct=EBI-11993296, EBI-13644623; CC Q6L8G4; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11993296, EBI-1210753; CC Q6L8G4; P32242: OTX1; NbExp=3; IntAct=EBI-11993296, EBI-740446; CC Q6L8G4; Q12837: POU4F2; NbExp=3; IntAct=EBI-11993296, EBI-17236143; CC Q6L8G4; Q9UGC6: RGS17; NbExp=5; IntAct=EBI-11993296, EBI-3918154; CC Q6L8G4; O76081-6: RGS20; NbExp=3; IntAct=EBI-11993296, EBI-10178530; CC Q6L8G4; Q9NR46: SH3GLB2; NbExp=3; IntAct=EBI-11993296, EBI-749607; CC Q6L8G4; P49901: SMCP; NbExp=5; IntAct=EBI-11993296, EBI-750494; CC Q6L8G4; Q9C004: SPRY4; NbExp=3; IntAct=EBI-11993296, EBI-354861; CC Q6L8G4; Q8WZ59: TMEM190; NbExp=3; IntAct=EBI-11993296, EBI-10278423; CC Q6L8G4; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11993296, EBI-5235829; CC Q6L8G4; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11993296, EBI-10249550; CC Q6L8G4; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11993296, EBI-11957216; CC -!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any other CC tissues. {ECO:0000269|PubMed:15144888}. CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB126080; BAD20207.1; -; mRNA. DR CCDS; CCDS41685.1; -. DR RefSeq; NP_001005405.1; NM_001005405.2. DR AlphaFoldDB; Q6L8G4; -. DR BioGRID; 136248; 58. DR IntAct; Q6L8G4; 56. DR STRING; 9606.ENSP00000381541; -. DR iPTMnet; Q6L8G4; -. DR PhosphoSitePlus; Q6L8G4; -. DR BioMuta; KRTAP5-11; -. DR MassIVE; Q6L8G4; -. DR PaxDb; 9606-ENSP00000381541; -. DR PeptideAtlas; Q6L8G4; -. DR Antibodypedia; 77334; 2 antibodies from 2 providers. DR DNASU; 440051; -. DR Ensembl; ENST00000398530.1; ENSP00000381541.1; ENSG00000204571.7. DR GeneID; 440051; -. DR KEGG; hsa:440051; -. DR MANE-Select; ENST00000398530.1; ENSP00000381541.1; NM_001005405.3; NP_001005405.1. DR UCSC; uc001oqu.3; human. DR AGR; HGNC:23606; -. DR CTD; 440051; -. DR GeneCards; KRTAP5-11; -. DR HGNC; HGNC:23606; KRTAP5-11. DR HPA; ENSG00000204571; Tissue enriched (skin). DR neXtProt; NX_Q6L8G4; -. DR OpenTargets; ENSG00000204571; -. DR PharmGKB; PA134989436; -. DR VEuPathDB; HostDB:ENSG00000204571; -. DR eggNOG; ENOG502TE7N; Eukaryota. DR GeneTree; ENSGT01060000250173; -. DR HOGENOM; CLU_097966_1_0_1; -. DR InParanoid; Q6L8G4; -. DR PathwayCommons; Q6L8G4; -. DR Reactome; R-HSA-6805567; Keratinization. DR SignaLink; Q6L8G4; -. DR BioGRID-ORCS; 440051; 287 hits in 1061 CRISPR screens. DR ChiTaRS; KRTAP5-11; human. DR GenomeRNAi; 440051; -. DR Pharos; Q6L8G4; Tdark. DR PRO; PR:Q6L8G4; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; Q6L8G4; Protein. DR Bgee; ENSG00000204571; Expressed in nucleus accumbens and 33 other tissues. DR ExpressionAtlas; Q6L8G4; baseline and differential. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0045095; C:keratin filament; IEA:InterPro. DR InterPro; IPR002494; KAP. DR Pfam; PF13885; Keratin_B2_2; 1. PE 1: Evidence at protein level; KW Keratin; Reference proteome; Repeat. FT CHAIN 1..156 FT /note="Keratin-associated protein 5-11" FT /id="PRO_0000184109" FT REPEAT 35..38 FT /note="1" FT REPEAT 41..44 FT /note="2" FT REPEAT 47..50 FT /note="3" FT REPEAT 87..90 FT /note="4" FT REPEAT 121..124 FT /note="5" FT REPEAT 146..149 FT /note="6" FT REGION 35..149 FT /note="6 X 4 AA repeats of C-C-X-P" SQ SEQUENCE 156 AA; 14610 MW; 42BEF951559C0A50 CRC64; MGCCGCSGGC GSGCGGCGSG SGGCGSGCGG CGSSCCVPIC CCKPVCCCVP ACSCSSCGSC GGSKGGCGSC GSSKGGCGSC GCSQSNCCKP CCSSSGCGSF CCQSSCSKPC CCQSSCCQSS CCKPCCCQSS CCQSSCFKPC CCQSSCCVPV CCQCKI //