ID IL6_TAKRU Reviewed; 227 AA. AC Q6L6X6; DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 29-SEP-2021, entry version 83. DE RecName: Full=Interleukin-6; DE Short=IL-6; DE Flags: Precursor; GN Name=il6; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND RP INDUCTION. RX PubMed=15936434; DOI=10.1016/j.dci.2005.01.002; RA Bird S., Zou J., Savan R., Kono T., Sakai M., Woo J., Secombes C.; RT "Characterisation and expression analysis of an interleukin 6 homologue in RT the Japanese pufferfish, Fugu rubripes."; RL Dev. Comp. Immunol. 29:775-789(2005). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Ram S., Sakai M.; RT "Characterization of a novel interleukin 6 from fugu."; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytokine with a wide variety of biological functions in CC immunity, tissue regeneration, and metabolism. Binds to IL6R, then the CC complex associates to the signaling subunit IL6ST/gp130 to trigger the CC intracellular IL6-signaling pathway. The interaction with the membrane- CC bound IL6R and IL6ST stimulates 'classic signaling', whereas the CC binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. CC Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R CC complexes on transmitter cells activate IL6ST receptors on neighboring CC receiver cells. {ECO:0000250|UniProtKB:P05231}. CC -!- SUBUNIT: Component of a hexamer of two molecules each of IL6, IL6R and CC IL6ST; first binds to IL6R to associate with the signaling subunit CC IL6ST. {ECO:0000250|UniProtKB:P05231}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05231}. CC -!- TISSUE SPECIFICITY: After induction, highly expressed in spleen. Can CC also be expressed in kidney after incubation with PHA. CC {ECO:0000269|PubMed:15936434}. CC -!- INDUCTION: By LPS and PBS. {ECO:0000269|PubMed:15936434}. CC -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ544721; CAD67608.1; -; mRNA. DR EMBL; AJ544722; CAD67609.1; -; Genomic_DNA. DR EMBL; AB178902; BAD18930.1; -; Genomic_DNA. DR RefSeq; NP_001027894.1; NM_001032722.1. DR SMR; Q6L6X6; -. DR STRING; 31033.ENSTRUP00000021935; -. DR Ensembl; ENSTRUT00000022026; ENSTRUP00000021936; ENSTRUG00000008735. DR GeneID; 503562; -. DR KEGG; tru:503562; -. DR CTD; 100628202; -. DR GeneTree; ENSGT00390000000878; -. DR HOGENOM; CLU_1253220_0_0_1; -. DR InParanoid; Q6L6X6; -. DR OrthoDB; 1144279at2759; -. DR Proteomes; UP000005226; Chromosome 12. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0005138; F:interleukin-6 receptor binding; IEA:InterPro. DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW. DR GO; GO:0042593; P:glucose homeostasis; ISS:UniProtKB. DR GO; GO:0072574; P:hepatocyte proliferation; ISS:UniProtKB. DR GO; GO:0070102; P:interleukin-6-mediated signaling pathway; ISS:UniProtKB. DR GO; GO:0097421; P:liver regeneration; ISS:UniProtKB. DR GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; ISS:UniProtKB. DR GO; GO:0070092; P:regulation of glucagon secretion; ISS:UniProtKB. DR GO; GO:0050796; P:regulation of insulin secretion; ISS:UniProtKB. DR GO; GO:0014823; P:response to activity; ISS:UniProtKB. DR GO; GO:0072540; P:T-helper 17 cell lineage commitment; IEA:InterPro. DR GO; GO:0010573; P:vascular endothelial growth factor production; ISS:UniProtKB. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR003574; IL-6. DR InterPro; IPR030474; IL-6/GCSF/MGF. DR InterPro; IPR030473; IL6/GCSF/MGF_CS. DR PANTHER; PTHR10511; PTHR10511; 1. DR PANTHER; PTHR10511:SF3; PTHR10511:SF3; 1. DR Pfam; PF00489; IL6; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00254; INTERLEUKIN_6; 1. PE 2: Evidence at transcript level; KW Acute phase; Cytokine; Disulfide bond; Growth factor; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..22 FT /evidence="ECO:0000255" FT CHAIN 23..227 FT /note="Interleukin-6" FT /id="PRO_0000387952" FT REGION 24..45 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 93..103 FT /evidence="ECO:0000250" SQ SEQUENCE 227 AA; 25606 MW; E6ABE6215B397D3B CRC64; MASISYLLAP LVLAAVLQPT AGAPLDAPTE SPAGETSGEE AETGSPDDAL AVALESVLGA TKLHKNEFLV EFQGEVKYDF LDRYKIPSLP AKCPYSNFGK DACLRRLLEG LLIYSVLLKR VEEEFPSSSI LSEVRFYSNI LIKELENKVR DRDQVMRLTS SQEEQLLKDT DYPDTFHRKM TAHGILYNLH YFLVDCRRVI NKRAKHRESA GSRVVRAVTF YHPKKRS //