ID IL6_TAKRU Reviewed; 227 AA. AC Q6L6X6; DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot. DT 05-JUL-2004, sequence version 1. DT 24-JUN-2015, entry version 64. DE RecName: Full=Interleukin-6; DE Short=IL-6; DE Flags: Precursor; GN Name=il6; OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; OC Takifugu. OX NCBI_TaxID=31033; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND RP INDUCTION. RX PubMed=15936434; DOI=10.1016/j.dci.2005.01.002; RA Bird S., Zou J., Savan R., Kono T., Sakai M., Woo J., Secombes C.; RT "Characterisation and expression analysis of an interleukin 6 RT homologue in the Japanese pufferfish, Fugu rubripes."; RL Dev. Comp. Immunol. 29:775-789(2005). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Ram S., Sakai M.; RT "Characterization of a novel interleukin 6 from fugu."; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Cytokine with a wide variety of biological functions. It CC is a potent inducer of the acute phase response (By similarity). CC {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. CC -!- TISSUE SPECIFICITY: After induction, highly expressed in spleen. CC Can also be expressed in kidney after incubation with PHA. CC {ECO:0000269|PubMed:15936434}. CC -!- INDUCTION: By LPS and PBS. {ECO:0000269|PubMed:15936434}. CC -!- SIMILARITY: Belongs to the IL-6 superfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ544721; CAD67608.1; -; mRNA. DR EMBL; AJ544722; CAD67609.1; -; Genomic_DNA. DR EMBL; AB178902; BAD18930.1; -; Genomic_DNA. DR RefSeq; NP_001027894.1; NM_001032722.1. DR UniGene; Tru.3485; -. DR ProteinModelPortal; Q6L6X6; -. DR STRING; 31033.ENSTRUP00000021935; -. DR Ensembl; ENSTRUT00000022026; ENSTRUP00000021936; ENSTRUG00000008735. DR GeneID; 503562; -. DR KEGG; tru:503562; -. DR CTD; 100136689; -. DR eggNOG; NOG314829; -. DR GeneTree; ENSGT00510000050593; -. DR HOGENOM; HOG000206019; -. DR InParanoid; Q6L6X6; -. DR KO; K05405; -. DR Proteomes; UP000005226; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 1.20.1250.10; -; 1. DR InterPro; IPR009079; 4_helix_cytokine-like_core. DR InterPro; IPR012351; 4_helix_cytokine_core. DR InterPro; IPR003574; IL-6. DR InterPro; IPR003573; IL-6/IL-23/GCSF/MGF. DR InterPro; IPR030473; IL6/GCSF/MGF_CS. DR PANTHER; PTHR11457; PTHR11457; 1. DR Pfam; PF00489; IL6; 1. DR SUPFAM; SSF47266; SSF47266; 1. DR PROSITE; PS00254; INTERLEUKIN_6; 1. PE 2: Evidence at transcript level; KW Acute phase; Complete proteome; Cytokine; Disulfide bond; KW Growth factor; Reference proteome; Secreted; Signal. FT SIGNAL 1 22 {ECO:0000255}. FT CHAIN 23 227 Interleukin-6. FT /FTId=PRO_0000387952. FT DISULFID 93 103 {ECO:0000250}. SQ SEQUENCE 227 AA; 25606 MW; E6ABE6215B397D3B CRC64; MASISYLLAP LVLAAVLQPT AGAPLDAPTE SPAGETSGEE AETGSPDDAL AVALESVLGA TKLHKNEFLV EFQGEVKYDF LDRYKIPSLP AKCPYSNFGK DACLRRLLEG LLIYSVLLKR VEEEFPSSSI LSEVRFYSNI LIKELENKVR DRDQVMRLTS SQEEQLLKDT DYPDTFHRKM TAHGILYNLH YFLVDCRRVI NKRAKHRESA GSRVVRAVTF YHPKKRS //