ID Q6L6X6_FUGRU PRELIMINARY; PRT; 227 AA. AC Q6L6X6; DT 05-JUL-2004 (TrEMBLrel. 27, Created) DT 05-JUL-2004 (TrEMBLrel. 27, Last sequence update) DT 13-SEP-2005 (TrEMBLrel. 31, Last annotation update) DE Interleukin-6. GN Name=IL-6; Synonyms=il-6; OS Fugu rubripes (Japanese pufferfish) (Takifugu rubripes). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; OC Acanthomorpha; Acanthopterygii; Percomorpha; Tetraodontiformes; OC Tetradontoidea; Tetraodontidae; Takifugu. OX NCBI_TaxID=31033; RN [1] RP NUCLEOTIDE SEQUENCE. RA Ram S., Sakai M.; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RX PubMed=15936434; DOI=10.1016/j.dci.2005.01.002; RA Bird S., Zou J., Savan R., Kono T., Sakai M., Woo J., Secombes C.; RT "Characterisation and expression analysis of an interleukin 6 RT homologue in the Japanese pufferfish, Fugu rubripes."; RL Dev. Comp. Immunol. 29:775-789(2005). CC -!- FUNCTION: IL-6 is a cytokine with a wide variety of biological CC functions: it plays an essential role in the final differentiation CC of B-cells into Ig-secreting cells, it induces myeloma and CC plasmacytoma growth, it induces nerve cells differentiation, in CC hepatocytes it induces acute phase reactants (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB178902; BAD18930.1; -; Genomic_DNA. DR EMBL; AJ544721; CAD67608.1; -; mRNA. DR EMBL; AJ544722; CAD67609.1; -; Genomic_DNA. DR GO; GO:0005615; C:extracellular space; IEA. DR GO; GO:0005125; F:cytokine activity; IEA. DR GO; GO:0005138; F:interleukin-6 receptor binding; IEA. DR GO; GO:0006953; P:acute-phase response; IEA. DR InterPro; IPR012351; Cytokine_4_hlx. DR InterPro; IPR003573; IL6_MGF_GCSF. DR InterPro; IPR003574; Interleukin_6. DR PANTHER; PTHR11457; Interleukin_6; 1. DR Pfam; PF00489; IL6; 1. DR PRINTS; PR00433; IL6GCSFMGF. DR ProDom; PD004356; Interleukin_6; 1. DR PROSITE; PS00254; INTERLEUKIN_6; 1. KW Acute phase; Cytokine; Growth factor. SQ SEQUENCE 227 AA; 25606 MW; E6ABE6215B397D3B CRC64; MASISYLLAP LVLAAVLQPT AGAPLDAPTE SPAGETSGEE AETGSPDDAL AVALESVLGA TKLHKNEFLV EFQGEVKYDF LDRYKIPSLP AKCPYSNFGK DACLRRLLEG LLIYSVLLKR VEEEFPSSSI LSEVRFYSNI LIKELENKVR DRDQVMRLTS SQEEQLLKDT DYPDTFHRKM TAHGILYNLH YFLVDCRRVI NKRAKHRESA GSRVVRAVTF YHPKKRS //