ID Q6KED3_HUMAN Unreviewed; 75 AA. AC Q6KED3; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JAN-2024, entry version 93. DE SubName: Full=Cystic fibrosis transmembrane conductance regulator {ECO:0000313|EMBL:CAE00728.1}; DE Flags: Fragment; GN Name=CFTR {ECO:0000313|EMBL:CAE00728.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE00728.1}; RN [1] {ECO:0000313|EMBL:CAE00728.1} RP NUCLEOTIDE SEQUENCE. RA Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., RA Marques B., Beck S., Penque D., Amaral M.D.; RT "An engineered genomic CFTR construct is expressed and correctly spliced in RT the human lung sarcoma cell line HT1080."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ575013; CAE00727.1; -; Genomic_DNA. DR EMBL; AJ575014; CAE00728.1; -; Genomic_DNA. DR EMBL; AJ575015; CAE00729.1; -; Genomic_DNA. DR EMBL; AJ575016; CAE00730.1; -; Genomic_DNA. DR EMBL; AJ575017; CAE00731.1; -; Genomic_DNA. DR AlphaFoldDB; Q6KED3; -. DR PeptideAtlas; Q6KED3; -. DR ChiTaRS; CFTR; human. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW. DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0005254; F:chloride channel activity; IEA:InterPro. DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR036640; ABC1_TM_sf. DR InterPro; IPR009147; CFTR/ABCC7. DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1. DR PANTHER; PTHR24223:SF19; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; 1. DR Pfam; PF00664; ABC_membrane; 1. DR PRINTS; PR01851; CYSFIBREGLTR. DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1. DR PROSITE; PS50929; ABC_TM1F; 1. PE 4: Predicted; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 56..74 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..75 FT /note="ABC transmembrane type-1" FT /evidence="ECO:0000259|PROSITE:PS50929" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAE00728.1" FT NON_TER 75 FT /evidence="ECO:0000313|EMBL:CAE00728.1" SQ SEQUENCE 75 AA; 9014 MW; E597D12E3DD2E2A5 CRC64; RSPIFTHLVT SLKGLWTLRA FGRQPYFETL FHKALNLHTA NWFLYLSTLR WFQMRIEMIF VIFFIAVTFI SILTT //