ID Q6KED3_HUMAN Unreviewed; 75 AA. AC Q6KED3; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 08-MAY-2019, entry version 78. DE SubName: Full=Cystic fibrosis transmembrane conductance regulator {ECO:0000313|EMBL:CAE00728.1}; DE Flags: Fragment; GN Name=CFTR {ECO:0000313|EMBL:CAE00728.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAE00728.1}; RN [1] {ECO:0000313|EMBL:CAE00728.1} RP NUCLEOTIDE SEQUENCE. RA Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., RA Marques B., Beck S., Penque D., Amaral M.D.; RT "An engineered genomic CFTR construct is expressed and correctly RT spliced in the human lung sarcoma cell line HT1080."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ575013; CAE00727.1; -; Genomic_DNA. DR EMBL; AJ575014; CAE00728.1; -; Genomic_DNA. DR EMBL; AJ575015; CAE00729.1; -; Genomic_DNA. DR EMBL; AJ575016; CAE00730.1; -; Genomic_DNA. DR EMBL; AJ575017; CAE00731.1; -; Genomic_DNA. DR PeptideAtlas; Q6KED3; -. DR eggNOG; KOG0054; Eukaryota. DR eggNOG; COG1132; LUCA. DR ChiTaRS; CFTR; human. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. DR GO; GO:0005254; F:chloride channel activity; IEA:InterPro. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR036640; ABC1_TM_sf. DR InterPro; IPR009147; CFTR/ABCC7. DR PANTHER; PTHR24223:SF19; PTHR24223:SF19; 1. DR Pfam; PF00664; ABC_membrane; 1. DR PRINTS; PR01851; CYSFIBREGLTR. DR SUPFAM; SSF90123; SSF90123; 1. DR PROSITE; PS50929; ABC_TM1F; 1. PE 4: Predicted; KW Membrane {ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius, ECO:0000313|EMBL:CAE00728.1}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 56 74 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 75 ABC transmembrane type-1. FT {ECO:0000259|PROSITE:PS50929}. FT NON_TER 1 1 {ECO:0000313|EMBL:CAE00728.1}. FT NON_TER 75 75 {ECO:0000313|EMBL:CAE00728.1}. SQ SEQUENCE 75 AA; 9014 MW; E597D12E3DD2E2A5 CRC64; RSPIFTHLVT SLKGLWTLRA FGRQPYFETL FHKALNLHTA NWFLYLSTLR WFQMRIEMIF VIFFIAVTFI SILTT //