ID Q6KED3_HUMAN Unreviewed; 75 AA. AC Q6KED3; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-NOV-2009, entry version 38. DE SubName: Full=Cystic fibrosis transmembrane conductance regulator; DE Flags: Fragment; GN Name=CFTR; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Schindelhauer D., Laner A., Cattani S., Christan S., Ramalho A.S., RA Marques B., Beck S., Penque D., Amaral M.D.; RT "An engineered genomic CFTR construct is expressed and correctly RT spliced in the human lung sarcoma cell line HT1080."; RL Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ575013; CAE00727.1; -; Genomic_DNA. DR EMBL; AJ575014; CAE00728.1; -; Genomic_DNA. DR EMBL; AJ575015; CAE00729.1; -; Genomic_DNA. DR EMBL; AJ575016; CAE00730.1; -; Genomic_DNA. DR EMBL; AJ575017; CAE00731.1; -; Genomic_DNA. DR IPI; IPI00853069; -. DR UniGene; Hs.489786; -. DR UniGene; Hs.621460; -. DR UniGene; Hs.661104; -. DR STRING; Q6KED3; -. DR Ensembl; ENST00000003084; ENSP00000003084; ENSG00000001626; Homo sapiens. DR Ensembl; ENST00000426809; ENSP00000389119; ENSG00000001626; Homo sapiens. DR Ensembl; ENST00000454343; ENSP00000403677; ENSG00000001626; Homo sapiens. DR HGNC; HGNC:1884; CFTR. DR HOVERGEN; Q6KED3; -. DR ArrayExpress; Q6KED3; -. DR Bgee; Q6KED3; -. DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Compara. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0042626; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro. DR GO; GO:0005254; F:chloride channel activity; IEA:InterPro. DR GO; GO:0006695; P:cholesterol biosynthetic process; IEA:Compara. DR GO; GO:0030301; P:cholesterol transport; IEA:Compara. DR GO; GO:0030324; P:lung development; IEA:Compara. DR GO; GO:0042493; P:response to drug; IEA:Compara. DR GO; GO:0043627; P:response to estrogen stimulus; IEA:Compara. DR GO; GO:0043434; P:response to peptide hormone stimulus; IEA:Compara. DR GO; GO:0030321; P:transepithelial chloride transport; IEA:Compara. DR GO; GO:0042311; P:vasodilation; IEA:Compara. DR InterPro; IPR011527; ABC_TM_1. DR InterPro; IPR001140; ABC_TM_transpt. DR InterPro; IPR017940; ABC_transporter_type1. DR InterPro; IPR005291; cAMP_cl_channel. DR InterPro; IPR009147; CysFib_conduc_TM. DR PANTHER; PTHR19242:SF8; cAMP_cl_channel; 1. DR Pfam; PF00664; ABC_membrane; 1. DR PRINTS; PR01851; CYSFIBREGLTR. DR PROSITE; PS50929; ABC_TM1F; 1. PE 2: Evidence at transcript level; KW Transmembrane. FT NON_TER 1 1 FT NON_TER 75 75 SQ SEQUENCE 75 AA; 9014 MW; E597D12E3DD2E2A5 CRC64; RSPIFTHLVT SLKGLWTLRA FGRQPYFETL FHKALNLHTA NWFLYLSTLR WFQMRIEMIF VIFFIAVTFI SILTT //