ID Q6JH47_SARS Unreviewed; 4382 AA. AC Q6JH47; DT 05-JUL-2004, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 1. DT 24-JUL-2024, entry version 136. DE SubName: Full=Orf1a polyprotein {ECO:0000313|EMBL:AAR23244.1}; OS SARS coronavirus Sino1-11. OC Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; OC Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; OC Betacoronavirus; Sarbecovirus; OC Severe acute respiratory syndrome coronavirus. OX NCBI_TaxID=255730 {ECO:0000313|EMBL:AAR23244.1, ECO:0000313|Proteomes:UP000123303}; RN [1] {ECO:0000313|EMBL:AAR23244.1, ECO:0000313|Proteomes:UP000123303} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Sino1-11 {ECO:0000313|EMBL:AAR23244.1}; RX PubMed=16269206; DOI=10.1016/j.vaccine.2004.12.032; RA Zhang J., Liu Y., Hu L., Gao Q., Zhang Z., Zhang X., Chen J., Gong X., RA Song L., Liu Y., Li J., Li S., Huang J., Ning Y., Gao H., Qin C., Dong X., RA Wei J., Dong G., Yin W.; RT "Preparation and characterization of SARS in-house reference antiserum."; RL Vaccine 23:5666-5669(2005). CC -!- CATALYTIC ACTIVITY: CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- CC residue protein attached to proteins as an intracellular targeting CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|ARBA:ARBA00000707}; CC -!- SUBCELLULAR LOCATION: Host cytoplasm, host perinuclear region CC {ECO:0000256|ARBA:ARBA00004407}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the coronaviruses polyprotein 1ab family. CC {ECO:0000256|ARBA:ARBA00008087, ECO:0000256|PROSITE-ProRule:PRU01294}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01337}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY485277; AAR23244.1; -; Genomic_RNA. DR MEROPS; C30.005; -. DR Proteomes; UP000123303; Genome. DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW. DR GO; GO:0044220; C:host cell perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC. DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0002151; F:G-quadruplex RNA binding; IEA:InterPro. DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW. DR GO; GO:0008242; F:omega peptidase activity; IEA:InterPro. DR GO; GO:0003727; F:single-stranded RNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0039520; P:induction by virus of host autophagy; IEA:UniProtKB-KW. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW. DR GO; GO:0039595; P:symbiont-mediated degradation of host mRNA; IEA:UniProtKB-UniRule. DR GO; GO:0039648; P:symbiont-mediated perturbation of host ubiquitin-like protein modification; IEA:UniProtKB-KW. DR GO; GO:0039579; P:symbiont-mediated suppression of host ISG15-protein conjugation; IEA:UniProtKB-KW. DR GO; GO:0039502; P:symbiont-mediated suppression of host type I interferon-mediated signaling pathway; IEA:UniProtKB-UniRule. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR GO; GO:0019082; P:viral protein processing; IEA:InterPro. DR GO; GO:0019049; P:virus-mediated perturbation of host defense response; IEA:UniProtKB-KW. DR CDD; cd21560; betaCoV-Nsp6; 1. DR CDD; cd21516; betaCoV_Nsp2_SARS-like; 1. DR CDD; cd21666; betaCoV_Nsp5_Mpro; 1. DR CDD; cd21827; betaCoV_Nsp7; 1. DR CDD; cd21831; betaCoV_Nsp8; 1. DR CDD; cd21898; betaCoV_Nsp9; 1. DR CDD; cd21732; betaCoV_PLPro; 1. DR CDD; cd21872; CoV_Nsp10; 1. DR CDD; cd21473; cv_Nsp4_TM; 1. DR CDD; cd21563; Macro_cv_SUD-M_Nsp3-like; 1. DR CDD; cd21562; Macro_cv_SUD-N_Nsp3-like; 1. DR CDD; cd21557; Macro_X_Nsp3-like; 1. DR CDD; cd22662; SARS-CoV-like_Nsp1_C; 1. DR CDD; cd21796; SARS-CoV-like_Nsp1_N; 1. DR CDD; cd21814; SARS-CoV-like_Nsp3_betaSM; 1. DR CDD; cd21822; SARS-CoV-like_Nsp3_NAB; 1. DR CDD; cd21525; SUD_C_SARS-CoV_Nsp3; 1. DR CDD; cd21717; TM_Y_SARS-CoV-like_Nsp3_C; 1. DR CDD; cd21467; Ubl1_cv_Nsp3_N-like; 1. DR Gene3D; 1.10.8.1190; -; 1. DR Gene3D; 2.60.120.1680; -; 1. DR Gene3D; 3.10.20.350; -; 1. DR Gene3D; 3.10.20.540; -; 1. DR Gene3D; 6.10.140.2090; -; 1. DR Gene3D; 1.10.150.420; Coronavirus nonstructural protein 4 C-terminus; 1. DR Gene3D; 3.40.30.150; Coronavirus polyprotein cleavage domain; 1. DR Gene3D; 3.40.220.10; Leucine Aminopeptidase, subunit E, domain 1; 1. DR Gene3D; 1.10.1840.10; main proteinase (3clpro) structure, domain 3; 1. DR Gene3D; 3.40.220.20; Nsp3, SUD-M subdomain; 1. DR Gene3D; 3.40.220.30; Nsp3, SUD-N subdomain; 1. DR Gene3D; 1.10.8.370; nsp7 replicase; 1. DR Gene3D; 3.30.70.3540; Nsp8 replicase, head domain; 1. DR Gene3D; 2.40.10.250; Replicase NSP9; 1. DR Gene3D; 3.40.50.11020; Replicase polyprotein, nucleic acid-binding domain; 1. DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2. DR InterPro; IPR046443; a/bCoV_NSP1_glob. DR InterPro; IPR046442; bCoV_NSP1_C. DR InterPro; IPR043613; CoV_NSP2_C. DR InterPro; IPR047573; CoV_NSP2_M. DR InterPro; IPR049894; COV_NSP3_3ECTO. DR InterPro; IPR043611; CoV_NSP3_C. DR InterPro; IPR047566; CoV_NSP3_Y. DR InterPro; IPR032505; CoV_NSP4_C. DR InterPro; IPR043612; CoV_NSP4_N. DR InterPro; IPR022733; DPUP_SUD_C_bCoV. DR InterPro; IPR002589; Macro_dom. DR InterPro; IPR043472; Macro_dom-like. DR InterPro; IPR044371; Macro_X_NSP3-like. DR InterPro; IPR036333; NSP10_sf_CoV. DR InterPro; IPR021590; NSP1_glob_bCoV. DR InterPro; IPR038030; NSP1_glob_sf_bCoV. DR InterPro; IPR043615; NSP2_N_CoV. DR InterPro; IPR044389; NSP2_SARS-CoV-like. DR InterPro; IPR024375; NSP3_bCoV. DR InterPro; IPR047567; NSP3_G2M_bCoV. DR InterPro; IPR024358; NSP3_N_bCoV. DR InterPro; IPR032592; NSP3_NAB_bCoV. DR InterPro; IPR042570; NSP3_NAB_bCoV_sf. DR InterPro; IPR038166; NSP3_PL2pro_sf_bCoV. DR InterPro; IPR038400; NSP3_SUD-M_sf_bCoV. DR InterPro; IPR044864; NSP3_SUD-N_bCoV. DR InterPro; IPR044374; NSP3_SUD-N_SARS-CoV. DR InterPro; IPR043478; NSP3_SUD-N_sf_bCoV. DR InterPro; IPR044357; NSP3_Ubl1_dom_CoV. DR InterPro; IPR044353; Nsp3_Ubl2_dom_CoV. DR InterPro; IPR038083; NSP3A-like. DR InterPro; IPR038123; NSP4_C_sf_CoV. DR InterPro; IPR044367; NSP6_betaCoV. DR InterPro; IPR043610; NSP6_CoV. DR InterPro; IPR014828; NSP7_CoV. DR InterPro; IPR037204; NSP7_sf_CoV. DR InterPro; IPR014829; NSP8_CoV. DR InterPro; IPR037230; NSP8_sf_CoV. DR InterPro; IPR014822; NSP9_CoV. DR InterPro; IPR036499; NSP9_sf_CoV. DR InterPro; IPR013016; Peptidase_C16_CoV. DR InterPro; IPR008740; Peptidase_C30_CoV. DR InterPro; IPR043477; Peptidase_C30_dom3_CoV. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin. DR InterPro; IPR043177; PLpro_N_sf_CoV. DR InterPro; IPR043503; PLpro_palm_finger_dom_CoV. DR InterPro; IPR043178; PLpro_thumb_sf_CoV. DR InterPro; IPR018995; RNA_synth_NSP10_CoV. DR Pfam; PF16251; bCoV_NAB; 1. DR Pfam; PF11501; bCoV_NSP1; 1. DR Pfam; PF12379; bCoV_NSP3_N; 1. DR Pfam; PF12124; bCoV_SUD_C; 1. DR Pfam; PF11633; bCoV_SUD_M; 1. DR Pfam; PF09401; CoV_NSP10; 1. DR Pfam; PF19212; CoV_NSP2_C; 1. DR Pfam; PF19211; CoV_NSP2_N; 1. DR Pfam; PF19218; CoV_NSP3_C; 1. DR Pfam; PF16348; CoV_NSP4_C; 1. DR Pfam; PF19217; CoV_NSP4_N; 1. DR Pfam; PF19213; CoV_NSP6; 1. DR Pfam; PF08716; CoV_NSP7; 1. DR Pfam; PF08717; CoV_NSP8; 1. DR Pfam; PF08710; CoV_NSP9; 1. DR Pfam; PF08715; CoV_peptidase; 1. DR Pfam; PF01661; Macro; 1. DR Pfam; PF05409; Peptidase_C30; 1. DR SMART; SM00506; A1pp; 1. DR SUPFAM; SSF144246; Coronavirus NSP10-like; 1. DR SUPFAM; SSF140367; Coronavirus NSP7-like; 1. DR SUPFAM; SSF143076; Coronavirus NSP8-like; 1. DR SUPFAM; SSF52949; Macro domain-like; 1. DR SUPFAM; SSF159936; NSP3A-like; 1. DR SUPFAM; SSF101816; Replicase NSP9; 1. DR SUPFAM; SSF160099; SARS Nsp1-like; 1. DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1. DR PROSITE; PS51963; BCOV_NSP1_C; 1. DR PROSITE; PS51942; BCOV_NSP3C_C; 1. DR PROSITE; PS51941; BCOV_NSP3C_M; 1. DR PROSITE; PS51994; BCOV_NSP3E_G2M; 1. DR PROSITE; PS51945; BCOV_NSP3E_NAB; 1. DR PROSITE; PS51993; COV_3ECTO; 1. DR PROSITE; PS51952; COV_EXON_MTASE_COACT; 1. DR PROSITE; PS51962; COV_NSP1; 1. DR PROSITE; PS51991; COV_NSP2_C; 1. DR PROSITE; PS51990; COV_NSP2_M; 1. DR PROSITE; PS51989; COV_NSP2_N; 1. DR PROSITE; PS51992; COV_NSP3_Y; 1. DR PROSITE; PS51943; COV_NSP3A_UBL; 1. DR PROSITE; PS51944; COV_NSP3D_UBL; 1. DR PROSITE; PS51946; COV_NSP4C; 1. DR PROSITE; PS51949; COV_NSP7; 1. DR PROSITE; PS51950; COV_NSP8; 1. DR PROSITE; PS51951; COV_NSP9_SSRNA_BD; 1. DR PROSITE; PS51442; M_PRO; 1. DR PROSITE; PS51154; MACRO; 1. DR PROSITE; PS51124; PEPTIDASE_C16; 1. DR PROSITE; PS51940; SARS_NSP3C_N; 1. PE 3: Inferred from homology; KW Activation of host autophagy by virus {ECO:0000256|ARBA:ARBA00023050}; KW Decay of host mRNAs by virus {ECO:0000256|ARBA:ARBA00022616}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE- KW ProRule:PRU01337}; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|ARBA:ARBA00023247}; KW Eukaryotic host translation shutoff by virus KW {ECO:0000256|ARBA:ARBA00022809, ECO:0000256|PROSITE-ProRule:PRU01308}; KW Host cytoplasm {ECO:0000256|ARBA:ARBA00023200}; KW Host gene expression shutoff by virus {ECO:0000256|ARBA:ARBA00022995}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host mRNA suppression by virus {ECO:0000256|ARBA:ARBA00022557, KW ECO:0000256|PROSITE-ProRule:PRU01308}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|ARBA:ARBA00022632, ECO:0000256|PROSITE-ProRule:PRU01308}; KW Inhibition of host interferon signaling pathway by virus KW {ECO:0000256|ARBA:ARBA00022830, ECO:0000256|PROSITE-ProRule:PRU01308}; KW Inhibition of host ISG15 by virus {ECO:0000256|ARBA:ARBA00023208}; KW Interferon antiviral system evasion {ECO:0000256|ARBA:ARBA00023258}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE- KW ProRule:PRU01336}; Methyltransferase {ECO:0000256|ARBA:ARBA00022603}; KW Modulation of host ubiquitin pathway by viral deubiquitinase KW {ECO:0000256|ARBA:ARBA00022876}; KW Modulation of host ubiquitin pathway by virus KW {ECO:0000256|ARBA:ARBA00022662}; Protease {ECO:0000256|ARBA:ARBA00022670}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Ribosomal frameshifting {ECO:0000256|ARBA:ARBA00022758}; KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE- KW ProRule:PRU01289}; Thiol protease {ECO:0000256|ARBA:ARBA00022807}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}; KW Viral immunoevasion {ECO:0000256|ARBA:ARBA00023280, ECO:0000256|PROSITE- KW ProRule:PRU01308}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU01336}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00444}. FT TRANSMEM 2206..2231 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2314..2333 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2340..2371 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 2749..2768 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3020..3042 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3054..3078 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3115..3134 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3559..3582 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3588..3606 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3613..3634 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3660..3678 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3685..3701 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3721..3743 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 3755..3774 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 12..127 FT /note="CoV Nsp1 globular" FT /evidence="ECO:0000259|PROSITE:PS51962" FT DOMAIN 148..179 FT /note="BetaCoV Nsp1 C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51963" FT DOMAIN 183..456 FT /note="CoV Nsp2 N-terminal" FT /evidence="ECO:0000259|PROSITE:PS51989" FT DOMAIN 458..688 FT /note="CoV Nsp2 middle" FT /evidence="ECO:0000259|PROSITE:PS51990" FT DOMAIN 690..818 FT /note="CoV Nsp2 C-terminal" FT /evidence="ECO:0000259|PROSITE:PS51991" FT DOMAIN 822..930 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS51943" FT DOMAIN 1003..1169 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51154" FT DOMAIN 1207..1335 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51940" FT DOMAIN 1343..1470 FT /note="Macro" FT /evidence="ECO:0000259|PROSITE:PS51941" FT DOMAIN 1472..1538 FT /note="DPUP" FT /evidence="ECO:0000259|PROSITE:PS51942" FT DOMAIN 1542..1597 FT /note="Ubiquitin-like" FT /evidence="ECO:0000259|PROSITE:PS51944" FT DOMAIN 1611..1875 FT /note="Peptidase C16" FT /evidence="ECO:0000259|PROSITE:PS51124" FT DOMAIN 1888..1998 FT /note="Nucleic acid-binding" FT /evidence="ECO:0000259|PROSITE:PS51945" FT DOMAIN 2023..2132 FT /note="G2M" FT /evidence="ECO:0000259|PROSITE:PS51994" FT DOMAIN 2224..2294 FT /note="3Ecto" FT /evidence="ECO:0000259|PROSITE:PS51993" FT DOMAIN 2372..2740 FT /note="CoV Nsp3 Y" FT /evidence="ECO:0000259|PROSITE:PS51992" FT DOMAIN 3142..3240 FT /note="Nsp4C" FT /evidence="ECO:0000259|PROSITE:PS51946" FT DOMAIN 3241..3546 FT /note="Peptidase C30" FT /evidence="ECO:0000259|PROSITE:PS51442" FT DOMAIN 3837..3919 FT /note="RdRp Nsp7 cofactor" FT /evidence="ECO:0000259|PROSITE:PS51949" FT DOMAIN 3920..4117 FT /note="RdRp Nsp8 cofactor" FT /evidence="ECO:0000259|PROSITE:PS51950" FT DOMAIN 4118..4230 FT /note="Nsp9 ssRNA-binding" FT /evidence="ECO:0000259|PROSITE:PS51951" FT DOMAIN 4231..4369 FT /note="ExoN/MTase coactivator" FT /evidence="ECO:0000259|PROSITE:PS51952" FT REGION 972..1003 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1175..1198 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 2372..2462 FT /note="Y1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT REGION 2376..2389 FT /note="ZF1" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT REGION 2422..2432 FT /note="ZF2" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT REGION 2463..2740 FT /note="CoV-Y" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT REGION 2463..2557 FT /note="Y2" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT REGION 2558..2639 FT /note="Y3" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT REGION 2640..2740 FT /note="Y4" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01336" FT COMPBIAS 972..997 FT /note="Acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT DISULFID 2259..2265 FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01337" SQ SEQUENCE 4382 AA; 486357 MW; F8E9F8EDD0684B52 CRC64; MESLVLGVNE KTHVQLSLPV LQVRDVLVRG FGDSVEEALS EAREHLKNGT CGLVELEKGV LPQLEQPYVF IKRSDALSTN HGHKVVELVA EMDGIQYGRS GITLGVLVPH VGETPIAYRN VLLRKNGNKG AGGHSYGIDL KSYDLGDELG TDPIEDYEQN WNTKHGSGAL RELTRELNGG AVTRYVDNNF CGPDGYPLDC IKDFLARAGK SMCTLSEQLD YIESKRGVYC CRDHEHEIAW FTERSDKSYE HQTPFEIKSA KKFDTFKGEC PKFVFPLNSK VKVIQPRVEK KKTEGFMGRI RSVYPVASPQ ECNNMHLSTL MKCNHCDEVS WQTCDFLKAT CEHCGTENLV IEGPTTCGYL PTNAVVKMPC PACQDPEIGP EHSVADYHNH SNIETRLRKG GRTRCFGGCV FAYVGCYNKR AYWVPRASAD IGSGHTGITG DNVETLNEDL LEILSRERVN INIVGDFHLN EEVAIILASF SASTSAFIDT IKSLDYKSFK TIVESCGNYK VTKGKPVKGA WNIGQQRSVL TPLCGFPSQA AGVIRSIFAR TLDAANHSIP DLQRAAVTIL DGISEQSLRL VDAMVYTSDL LTNSVIIMAY VTGGLVQQTS QWLSNLLGTT VEKLRPIFEW IEAKLSAGVE FLKDAWEILK FLITGVFDIV KGQIQVASDN IKDCVKCFID VVNKALEMCI DQVTIAGAKL RSLNLGEVFI AQSKGLYRQC IRGKEQLQLL MPLKAPKEVT FLEGDSHDTV LTSEEVVLKN GELEALETPV DSFTNGAIVG TPVCVNGLML LEIKDKEQYC ALSPGLLATN NVFRLKGGAP IKGVTFGEDT VWEVQGYKNV RITFELDERV DKVLNEKCSV YTVESGTEVT EFACVVAEAV VKTLQPVSDL LTNMGIDLDE WSVATFYLFD DAGEENFSSR MYCSFYPPDE EEEDDAECEE EEIDETCEHE YGTEDDYQGL PLEFGASAET VRVEEEEEED WLDDTTEQSE IEPEPEPTPE EPVNQFTGYL KLTDNVAIKC VDIVKEAQSA NPMVIVNAAN IHLKHGGGVA GALNKATNGA MQKESDDYIK LNGPLTVGGS CLLSGHNLAK KCLHVVGPNL NAGEDIQLLK AAYENFNSQD ILLAPLLSAG IFGAKPLQSL QVCVQTVRTQ VYIAVNDKAL YEQVVMDYLD NLKPRVEAPK QEEPPNTEDS KTEEKSVVQK PVDVKPKIKA CIDEVTTTLE ETKFLTNKLL LFADINGKLY HDSQNMLRGE DMSFLEKDAP YMVGDVITSG DITCVVIPSK KAGGTTEMLS RALKKVPVDE YITTYPGQGC AGYTLEEAKT ALKKCKSAFY VLPSEAPNAK EEILGTVSWN LREMLAHAEE TRKLMPICMD VRAIMATIQR KYKGIKIQEG IVDYGVRFFF YTSKEPVASI ITKLNSLNEP LVTMPIGYVT HGFNLEEAAR CMRSLKAPAV VSVSSPDAVT TYNGYLTSSS KTSEEHFVET VSLAGSYRDW SYSGQRTELG VEFLKRGDKI VYHTLESPVE FHLDGEVLSL DKLKSLLSLR EVKTIKVFTT VDNTNLHTQL VDMSMTYGQQ FGPTYLDGAD VTKIKPHVNH EGKTFFVLPS DDTLRSEAFE YYHTLDESFL GRYMSALNHT KKWKFPQVGG LTSIKWADNN CYLSSVLLAL QQLEVKFNAP ALQEAYYRAR AGDAANFCAL ILAYSNKTVG ELGDVRETMT HLLQHANLES AKRVLNVVCK HCGQKTTTLT GVEAVMYMGT LSYDNLKTGV SIPCVCGRDA TQYLVQQESS FVMMSAPPAE YKLQQGTFLC ANEYTGNYQC GHYTHITAKE TLYRIDGAHL TKMSEYKGPV TDVFYKETSY TTTIKPVSYK LDGVTYTEIE PKLDGYYKKD NAYYTEQPID LVPTQPLPNA SFDNFKLTCS NTKFADDLNQ MTGFTKPASR ELSVTFFPDL NGDVVAIDYR HYSASFKKGA KLLHKPIVWH INQATTKTTF KPNTWCLRCL WSTKPVDTSN SFEVLAVEDT QGMDNLACES QQPTSEEVVE NPTIQKEVIE CDVKTTEVVG NVILKPSDEG VKVTQELGHE DLMAAYVENT SITIKKPNEL SLALGLKTIA THGIAAINSV PWSKILAYVK PFLGQAAITT SNCAKRLAQR VFNNYMPYVF TLLFQLCTFT KSTNSRIRAS LPTTIAKNSV KSVAKLCLDA GINYVKSPKF SKLFTIAMWL LLLSICLGSL ICVTAAFGVL LSNFGAPSYC NGVRELYLNS SNVTTMDFCE GSFPCSICLS GLDSLDSYPA LETIQVTISS YKLDLTILGL AAEWVLAYML FTKFFYLLGL SAIMQVFFGY FASHFISNSW LMWFIISIVQ MAPVSAMVRM YIFFASFYYI WKSYVHIMDG CTSSTCMMCY KRNRATRVEC TTIVNGMKRS FYVYANGGRG FCKTHNWNCL NCDTFCTGST FISDEVARDL SLQFKRPINP TDQSSYIVDS VAVKNGALHL YFDKAGQKTY ERHPLSHFVN LDNLRANNTK GSLPINVIVF DGKSKCDESA SKSASVYYSQ LMCQPILLLD QALVSDVGDS TEVSVKMFDA YVDTFSATFS VPMEKLKALV ATAHSELAKG VALDGVLSTF VSAARQGVVD TDVDTKDVIE CLKLSHHSDL EVTGDSCNNF MLTYNKVENM TPRDLGACID CNARHINAQV AKSHNVSLIW NVKDYMSLSE QLRKQIRSAA KKNNIPFRLT CATTRQVVNV ITTKISLKGG KIVSTCFKLM LKATLLCVLA ALVCYIVMPV HTLSIHDGYT NEIIGYKAIQ DGVTRDIIST DDCFANKHAG FDAWFSQRGG SYKNDKSCPV VAAIITREIG FIVPGLPGTV LRAINGDFLH FLPRVFSAVG NICYTPSKLI EYSDFATSAC VLAAECTIFK DAMGKPVPYC YDTNLLEGSI SYSELRPDTR YVLMDGSIIQ FPNTYLEGSV RVVTTFDAEY CRHGTCERSE VGICLSTSGR WVLNNEHYRA LSGVFCGVDA MNLIANIFTP LVQPVGALDV SASVVAGGII AILVTCAAYY FMKFRRVFGE YNHVVAANAL LFLMSFTILC LVPAYSFLPG VYSVFYLYLT FYFTNDVSFL AHLQWFAMFS PIVPFWITAI YVFCISLKHC HWFFNNYLRK RVMFNGVTFS TFEEAALCTF LLNKEMYLKL RSETLLPLTQ YNRYLALYNK YKYFSGALDT TSYREAACCH LAKALNDFSN SGADVLYQPP QTSITSAVLQ SGFRKMAFPS GKVEGCMVQV TCGTTTLNGL WLDDTVYCPR HVICTAEDML NPNYEDLLIR KANHSFLVQA GNVQLRVIGH SMQNCLLRLK VDTSNPKTPK YKFVRIQPGQ TFSVLACYNG SPSGVYQCAM RPNHTIKGSF LNGSCGSVGF NIDYDCVSFC YMHHMELPTG VHAGTDLEGK FYGPFVDRQT AQAAGTDTTI TLNVLAWLYA AVINGDRWFL NRFTTTLNDF NLVAMKYNYE PLTQDHVDIL GPLSAQTGIA VLDMCAALKE LLQNGMNGRT ILGSTILEDE FTPFDVVRQC SGVTFQGKFK KIVKGTHHWM LLTFLTSLLI LVQSTQWSLF FFVYENAFLP FTLGIMAIAA CAMLLVKHKH AFLCLFLLPS LATVAYFNMV YMPASWVMRI MTWLELADTS LSGYRLKDCV MYASALVLLI LMTARTVYDD AARRVWTLMN VITLVYKVYY GNALDQAISM WALVISVTSN YSGVVTTIMF LARAIVFVCV EYYPLLFITG NTLQCIMLVY CFLGYCCCCY FGLFCLLNRY FRLTLGVYDY LVSTQEFRYM NSQGLLPPKS SIDAFKLNIK LLGIGGKPCI KVATVQSKMS DVKCTSVVLL SVLQQLRVES SSKLWAQCVQ LHNDILLAKD TTEAFEKMVS LLSVLLSMQG AVDINRLCEE MLDNRATLQA IASEFSSLPS YAAYATAQEA YEQAVANGDS EVVLKKLKKS LNVAKSEFDR DAAMQRKLEK MADQAMTQMY KQARSEDKRA KVTSAMQTML FTMLRKLDND ALNNIINNAR DGCVPLNIIP LTTAAKLMVV VPDYGTYKNT CDGNTFTYAS ALWEIQQVVD ADSKIVQLSE INMDNSPNLA WPLIVTALRA NSAVKLQNNE LSPVALRQMS CAAGTTQTAC TDDNALAYYN NSKGGRFVLA LLSDHQDLKW ARFPKSDGTG TIYTELEPPC RFVTDTPKGP KVKYLYFIKG LNNLNRGMVL GSLAATVRLQ AGNATEVPAN STVLSFCAFA VDPAKAYKDY LASGGQPITN CVKMLCTHTG TGQAITVTPE ANMDQESFGG ASCCLYCRCH IDHPNPKGFC DLKGKYVQIP TTCANDPVGF TLRNTVCTVC GMWKGYGCSC DQLREPLMQS ADASTFLNGF AV //