ID   OR4F3_HUMAN             Reviewed;         312 AA.
AC   Q6IEY1; B2RPQ6;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 147.
DE   RecName: Full=Olfactory receptor 4F3/4F16/4F29;
DE   AltName: Full=Olfactory receptor OR1-1;
GN   Name=OR4F3;
GN   and
GN   Name=OR4F16;
GN   and
GN   Name=OR4F29;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- INTERACTION:
CC       Q6IEY1; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-18294332, EBI-17208936;
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F29";
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F3";
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4F16";
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DR   EMBL; AL732372; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC137547; AAI37548.1; -; mRNA.
DR   EMBL; BK004481; DAA04879.1; -; Genomic_DNA.
DR   CCDS; CCDS41221.1; -.
DR   CCDS; CCDS43415.1; -.
DR   CCDS; CCDS72675.1; -.
DR   RefSeq; NP_001005221.2; NM_001005221.2.
DR   RefSeq; NP_001005224.1; NM_001005224.1.
DR   RefSeq; NP_001005277.1; NM_001005277.1.
DR   RefSeq; XP_016857897.1; XM_017002408.1.
DR   RefSeq; XP_016857898.1; XM_017002409.1.
DR   RefSeq; XP_016857899.1; XM_017002410.1.
DR   RefSeq; XP_016857900.1; XM_017002411.1.
DR   RefSeq; XP_016864827.1; XM_017009338.1.
DR   SMR; Q6IEY1; -.
DR   BioGRID; 117786; 1.
DR   BioGRID; 123472; 1.
DR   BioGRID; 610156; 1.
DR   IntAct; Q6IEY1; 1.
DR   STRING; 9606.ENSP00000329982; -.
DR   GlyGen; Q6IEY1; 1 site.
DR   iPTMnet; Q6IEY1; -.
DR   PhosphoSitePlus; Q6IEY1; -.
DR   BioMuta; OR4F16; -.
DR   DMDM; 74762307; -.
DR   PaxDb; Q6IEY1; -.
DR   PRIDE; Q6IEY1; -.
DR   Antibodypedia; 57198; 60 antibodies from 14 providers.
DR   Antibodypedia; 78854; 1 antibodies from 1 providers.
DR   Antibodypedia; 78873; 11 antibodies from 3 providers.
DR   DNASU; 729759; -.
DR   Ensembl; ENST00000332831; ENSP00000329982; ENSG00000284662.
DR   Ensembl; ENST00000426406; ENSP00000409316; ENSG00000284733.
DR   Ensembl; ENST00000456475; ENSP00000394282; ENSG00000230178.
DR   GeneID; 26683; -.
DR   GeneID; 729759; -.
DR   GeneID; 81399; -.
DR   KEGG; hsa:26683; -.
DR   KEGG; hsa:729759; -.
DR   KEGG; hsa:81399; -.
DR   MANE-Select; ENST00000332831.5; ENSP00000329982.2; NM_001005277.1; NP_001005277.1.
DR   MANE-Select; ENST00000426406.4; ENSP00000409316.1; NM_001005221.2; NP_001005221.2.
DR   UCSC; uc010nxu.2; human.
DR   CTD; 26683; -.
DR   CTD; 729759; -.
DR   CTD; 81399; -.
DR   GeneCards; OR4F16; -.
DR   GeneCards; OR4F29; -.
DR   GeneCards; OR4F3; -.
DR   HGNC; HGNC:15079; OR4F16.
DR   HGNC; HGNC:31275; OR4F29.
DR   HGNC; HGNC:8300; OR4F3.
DR   HPA; ENSG00000230178; Not detected.
DR   HPA; ENSG00000284662; Not detected.
DR   HPA; ENSG00000284733; Not detected.
DR   neXtProt; NX_Q6IEY1; -.
DR   PharmGKB; PA32284; -.
DR   VEuPathDB; HostDB:ENSG00000230178; -.
DR   VEuPathDB; HostDB:ENSG00000284662; -.
DR   VEuPathDB; HostDB:ENSG00000284733; -.
DR   eggNOG; ENOG502TEJE; Eukaryota.
DR   GeneTree; ENSGT00940000162683; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q6IEY1; -.
DR   OMA; PLMIFRK; -.
DR   OrthoDB; 947815at2759; -.
DR   PhylomeDB; Q6IEY1; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q6IEY1; -.
DR   BioGRID-ORCS; 26683; 11 hits in 130 CRISPR screens.
DR   BioGRID-ORCS; 729759; 5 hits in 110 CRISPR screens.
DR   BioGRID-ORCS; 81399; 50 hits in 530 CRISPR screens.
DR   GeneWiki; OR4F16; -.
DR   GeneWiki; OR4F3; -.
DR   Pharos; Q6IEY1; Tdark.
DR   PRO; PR:Q6IEY1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q6IEY1; protein.
DR   Bgee; ENSG00000230178; Expressed in caudate nucleus and 58 other tissues.
DR   ExpressionAtlas; Q6IEY1; baseline.
DR   Genevisible; Q6IEY1; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IEA:InterPro.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 4F3/4F16/4F29"
FT                   /id="PRO_0000150551"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..195
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        196..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..235
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        236..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..269
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        270..289
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        290..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   312 AA;  35074 MW;  08285B196DC638FB CRC64;
     MDGENHSVVS EFLFLGLTHS WEIQLLLLVF SSVLYVASIT GNILIVFSVT TDPHLHSPMY
     FLLASLSFID LGACSVTSPK MIYDLFRKRK VISFGGCIAQ IFFIHVVGGV EMVLLIAMAF
     DRYVALCKPL HYLTIMSPRM CLSFLAVAWT LGVSHSLFQL AFLVNLAFCG PNVLDSFYCD
     LPRLLRLACT DTYRLQFMVT VNSGFICVGT FFILLISYVF ILFTVWKHSS GGSSKALSTL
     SAHSTVVLLF FGPPMFVYTR PHPNSQMDKF LAIFDAVLTP FLNPVVYTFR NKEMKAAIKR
     VCKQLVIYKR IS
//