ID Q6HAA1_MOUSE Unreviewed; 454 AA. AC Q6HAA1; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 22-FEB-2023, entry version 105. DE SubName: Full=GA-binding protein alpha-subunit {ECO:0000313|EMBL:AAO27832.1}; GN Name=Gabpa {ECO:0000313|EMBL:AAO27832.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAO27832.1}; RN [1] {ECO:0000313|EMBL:AAO27832.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=15199140; DOI=10.1128/MCB.24.13.5844-5849.2004; RA Ristevski S., O'Leary D.A., Thornell A.P., Owen M.J., Kola I., RA Hertzog P.J.; RT "The ETS transcription factor GABPalpha is essential for early RT embryogenesis."; RL Mol. Cell. Biol. 24:5844-5849(2004). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|RuleBase:RU004019}. CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562, CC ECO:0000256|RuleBase:RU004019}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AH012474; AAO27832.1; -; Genomic_DNA. DR EMBL; AF346289; AAO27832.1; JOINED; Genomic_DNA. DR AlphaFoldDB; Q6HAA1; -. DR EPD; Q6HAA1; -. DR PhylomeDB; Q6HAA1; -. DR ChiTaRS; Gabpa; mouse. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro. DR CDD; cd08534; SAM_PNT-GABP-alpha; 1. DR CDD; cd17039; Ubl_ubiquitin_like; 1. DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR000418; Ets_dom. DR InterPro; IPR046328; ETS_fam. DR InterPro; IPR024668; GABP_asu_N. DR InterPro; IPR003118; Pointed_dom. DR InterPro; IPR013761; SAM/pointed_sf. DR InterPro; IPR016312; TF_GA-bd_asu. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR PANTHER; PTHR11849; ETS; 1. DR PANTHER; PTHR11849:SF195; GA-BINDING PROTEIN ALPHA CHAIN; 1. DR Pfam; PF00178; Ets; 1. DR Pfam; PF11620; GABP-alpha; 1. DR Pfam; PF02198; SAM_PNT; 1. DR PIRSF; PIRSF001703; GABP_alpha; 1. DR PRINTS; PR00454; ETSDOMAIN. DR SMART; SM00413; ETS; 1. DR SMART; SM00251; SAM_PNT; 1. DR SUPFAM; SSF47769; SAM/Pointed domain; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00345; ETS_DOMAIN_1; 1. DR PROSITE; PS00346; ETS_DOMAIN_2; 1. DR PROSITE; PS50061; ETS_DOMAIN_3; 1. DR PROSITE; PS51433; PNT; 1. PE 3: Inferred from homology; KW DNA-binding {ECO:0000256|RuleBase:RU004019}; KW Nucleus {ECO:0000256|RuleBase:RU004019}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}. FT DOMAIN 168..251 FT /note="PNT" FT /evidence="ECO:0000259|PROSITE:PS51433" FT DOMAIN 320..400 FT /note="ETS" FT /evidence="ECO:0000259|PROSITE:PS50061" FT REGION 295..316 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 454 AA; 51363 MW; 76BC47EB2F563AAD CRC64; MTKREAEELI EIEIDGTEKA ECTEESIVEQ TYTPAECVSQ AIDINEPIGN LKKLLEPRLQ CSLDAHEICL QDIQLDPDRS LFDQGVKTDG TVQLSVQVIS YQGMEPKLNI LEIVKTAETV EVVIDPDAHH AEAEAHLVEE AQVITLDGTK HITTISDETS EQVTRWAAAL EGYRKEQERL GIPYDPIRWS TDQVLHWVVW VMKEFSMTDI DLTTLNISGR ELCSLNQEDF FQRVPRGEIL WSHLELLRKY VLASQEQQMN EIVTIDQPVQ IIPASVPPAT PTTIKVINSS AKAAKVQRSP RISGEDRSSP GNRTGNNGQI QLWQFLLELL TDKDARDCIS WVGDEGEFKL NQPELVAQKW GQRKNKPTMN YEKLSRALRY YYDGDMICKV QGKRFVYKFV CDLKTLIGYS AAELNRLVIE CEQKKLARMQ LHGIAQPVTA VALAATSLQA DKEI //