ID Q6FIV4_CANGA Unreviewed; 1579 AA. AC Q6FIV4; DT 19-JUL-2004, integrated into UniProtKB/TrEMBL. DT 19-JUL-2004, sequence version 1. DT 29-APR-2008, entry version 36. DE Candida glabrata strain CBS138 chromosome M complete sequence. GN OrderedLocusNames=CAGL0M11484g; OS Candida glabrata (Yeast) (Torulopsis glabrata). OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; OC Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; OC Candida. OX NCBI_TaxID=5478; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65; RX PubMed=15229592; DOI=10.1038/nature02579; RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., RA Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., RA Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., RA Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., RA Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., RA Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., RA Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., RA Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., RA Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., RA Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., RA Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., RA Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., RA Wincker P., Souciet J.-L.; RT "Genome evolution in yeasts."; RL Nature 430:35-44(2004). CC -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O. CC -!- CATALYTIC ACTIVITY: 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate CC = 3-dehydroquinate + phosphate. CC -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + 3-phosphoshikimate = CC phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. CC -!- PATHWAY: Context: Aromatic amino acids biosynthesis. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate CC biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: CC step 2/7. CC -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate CC biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: CC step 6/7. CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR380959; CAG62820.1; -; Genomic_DNA. DR RefSeq; XP_449840.1; -. DR GeneID; 2891409; -. DR KEGG; cgr:CAGL0M11484g; -. DR GO; GO:0005737; C:cytoplasm; IEA:InterPro. DR GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA:InterPro. DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:InterPro. DR GO; GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferas...; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:InterPro. DR GO; GO:0004765; F:shikimate kinase activity; IEA:InterPro. DR GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:InterPro. DR InterPro; IPR013785; Aldolase_TIM. DR InterPro; IPR002658; DHQ_synth_AroB. DR InterPro; IPR016037; DHQ_synth_AroB_sub. DR InterPro; IPR001381; DHquinase_I. DR InterPro; IPR001986; EPSP_synthase_core. DR InterPro; IPR006264; EPSP_synthase_subgroup. DR InterPro; IPR016040; NAD(P)-bd. DR InterPro; IPR008289; Pentafunct_AroM. DR InterPro; IPR010110; Shik_DHase_AROM. DR InterPro; IPR000623; Shik_kinase. DR InterPro; IPR013708; Shikimate_DHase-bd_N. DR InterPro; IPR006151; Shikm_DHase/Glu-tRNA_Rdtase. DR Gene3D; G3DSA:3.20.20.70; Aldolase_TIM; 1. DR Gene3D; G3DSA:3.65.10.10; EPSP_synthase; 1. DR Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1. DR PANTHER; PTHR21090:SF1; DHQ_synth_AroB; 1. DR Pfam; PF01761; DHQ_synthase; 1. DR Pfam; PF01487; DHquinase_I; 1. DR Pfam; PF00275; EPSP_synthase; 1. DR Pfam; PF01488; Shikimate_DH; 1. DR Pfam; PF08501; Shikimate_dh_N; 1. DR Pfam; PF01202; SKI; 1. DR PIRSF; PIRSF000514; Pentafunct_AroM; 1. DR PRINTS; PR01100; SHIKIMTKNASE. DR ProDom; PD005337; DHquinase_I; 1. DR ProDom; PD001867; EPSP_synth; 1. DR TIGRFAMs; TIGR01356; aroA; 1. DR TIGRFAMs; TIGR01357; aroB; 1. DR TIGRFAMs; TIGR01093; aroD; 1. DR TIGRFAMs; TIGR01809; Shik-DH-AROM; 1. DR PROSITE; PS01028; DEHYDROQUINASE_I; 1. DR PROSITE; PS00104; EPSP_SYNTHASE_1; 1. DR PROSITE; PS00885; EPSP_SYNTHASE_2; 1. DR PROSITE; PS01128; SHIKIMATE_KINASE; UNKNOWN_1. PE 3: Inferred from homology; KW Amino-acid biosynthesis; Aromatic amino acid biosynthesis; KW Complete proteome; Cytoplasm; Lyase; Transferase. SQ SEQUENCE 1579 AA; 174232 MW; 51A302AA2AA7CCF8 CRC64; MLVKVPILGR ETIHVGYGVR SHIVETIVGL KSSTYVVIND SNVGRVPYFQ ELLSDFEAQL PAGSRLLRYV VKPGEANKTR ATKEQIEDYL LSEGCTRDTV IVAVGGGIIG DMIGYVAATF MRGVRVVQVP TSLLAMVDSS IGGKTAVDTP LGKNFIGAFW QPEFVLVDIK WLQSLPKREF INGMAEVIKT ACIWNADEFQ RLETHADEFL HVVNTPKISE KEGFQLYDTD IESIKEHIFK LVLESIKVKA EVVSSDERES SLRNLLNFGH SIGHAYEAIL TPQALHGECV SIGMVKEAEL SRYLGILSAT QVARLSKILV AYGLPVSKDE KWFRELTLNK KTPLDTLLKK MSIDKKNDGS KKKVVLLETI GKCYGKSAHV VSDEDLRFVL TDETLVYPFN NIPRDQNKTV TPPGSKSISN RALVLAALGK GTCRIKNLLH SDDTKHMLTA VQELKGANIS WEDNGETVVL EGQGGSTLVA CENDLYLGNA GTASRFLTSV AALVNSTSQK DHVILTGNAR MQQRPIGPLV DSLRNNGIKI DYVKNEGCLP LKVHTDSVFK GGRIELAATV SSQYVSSILM CAPYAENPVT LALVGGKPIS ILYVEMTIKM MEKFGIKVEK STTEEYTYII PKGHYVNPAE YVIESDASSA TYPLAFAALT GTTVTVPNIG SASLQGDARF ATDVLQPMGC SVTQTATSTT VTGPPVGHLK PLKHVDMEPM TDAFLTACVV AAVAHDNDPT SKNTTTIEGI ANQRVKECNR IEAMCTQLAK FGVRTNELPD GIQVHGLHSI NDLKVPSIGN EAVGVCTYDD HRVAMSFSLL AGMVNSEQPN SSNPTPVRIL ERHCTGKTWP GWWDVLHTEL GAQLDGAEPL ELNSMKNAKK SVVIIGMRAA GKTTISRWCA AALGYKLVDL DTLFEERYGH GMIKDFVSQH GWEKFREEEA RIFKEVIENY GDAGYVFSSG GGLVESSESR RILKSFSKSG GYVLHLHRDI EETIMFLQKD PTRPAYVEEI REVWNRRESW YKDCSNFSFF APHCNSEVEF QNLRRAFTKF IRTITGVTTV DIPTRRSAFV CLTFENLTEY TNSLKAITYG CDAVEVRVDH LSNMDEDFVS KQISILRAST DGLPIIFTVR TKKQGGKFPD EDYETLQKLL ITALKVGVDY IDLELTLPIG IQYKVLNMKR NTKIIGSHHD FASAYPWDHS EWENRYNQAL AMDVDIVKFV GMAKSFEDNL MLERFRDSHT TKPLIAINMG AHGRVSRVLN TILTPVTSEH LSEVAAPGQL TVAEINRIYT EMGGITKKDF FVVGSPIGHS RSPVLHNTGY SVLGLPHHFD KFETTSAEEV KKHLLDNKAN LGGLAVTIPL KLDIIKYMDE LTESAKVIGA VNTVIPLGNS KFKGDNTDWL GIRNSLVSNG VPESVSGLSG LVVGAGGTSR AAIFALHKLG CQKIFIVNRT TEKLEELVKF FPEEYNIVPI KEAEEAEAVN ETIGVAVNCV PADKPLDAKL ESLLERLLLK SSHTHFVSTL VEAAYKPSVT PVMKLAKDKY QWRVVPGAQM LVHQGVAQFE TWNNCRAPFK AIYDAVTEI //