ID Q6FIV4_CANGA PRELIMINARY; PRT; 1579 AA. AC Q6FIV4; DT 05-JUL-2004 (TrEMBLrel. 27, Created) DT 05-JUL-2004 (TrEMBLrel. 27, Last sequence update) DT 05-JUL-2004 (TrEMBLrel. 27, Last annotation update) DE Candida glabrata strain CBS138 chromosome M complete sequence. GN OrderedLocusNames=CAGL0M11484g; OS Candida glabrata (Yeast) (Torulopsis glabrata). OC Eukaryota; Fungi; Ascomycota; Saccharomycotina; Saccharomycetes; OC Saccharomycetales; mitosporic Saccharomycetales; Candida. OX NCBI_TaxID=5478; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 2001 / CBS 138; RX PubMed=15229592; DOI=10.1038/nature02579; RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., RA Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., RA Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., RA Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C., RA Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., RA Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., RA Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., RA Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., RA Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., RA Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., RA Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., RA Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., RA Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., RA Wincker P., Souciet J.-L.; RT "Genome evolution in yeasts."; RL Nature 430:35-44(2004). CC -!- FUNCTION: The AROM polypeptide catalyzes 5 consecutive enzymatic CC reactions in prechorismate polyaromatic amino acid biosynthesis CC (By similarity). CC -!- CATALYTIC ACTIVITY: 3-dehydroquinate = 3-dehydroshikimate + H(2)O. CC -!- CATALYTIC ACTIVITY: 3-deoxy-arabino-heptulonate 7-phosphate = 3- CC dehydroquinate + phosphate. CC -!- CATALYTIC ACTIVITY: ATP + shikimate = ADP + shikimate 3-phosphate. CC -!- CATALYTIC ACTIVITY: Phosphoenolpyruvate + 3-phosphoshikimate = CC phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate. CC -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate + CC NADPH. CC -!- PATHWAY: Aromatic amino acids biosynthesis; shikimate pathway; CC fifth step. CC -!- PATHWAY: Aromatic amino acids biosynthesis; shikimate pathway; CC fourth step. CC -!- PATHWAY: Aromatic amino acids biosynthesis; shikimate pathway; CC second step. CC -!- PATHWAY: Aromatic amino acids biosynthesis; shikimate pathway; CC sixth step. CC -!- PATHWAY: Aromatic amino acids biosynthesis; shikimate pathway; CC third step. CC -!- SUBCELLULAR LOCATION: Cytoplasmic (By similarity). CC -!- SIMILARITY: In the 2nd section; belongs to the EPSP synthase CC family. CC -!- SIMILARITY: In the 3rd section; belongs to the shikimate kinase CC family. CC -!- SIMILARITY: In the C-terminal section; belongs to the shikimate CC dehydrogenase family. CC -!- SIMILARITY: In the N-terminal section; belongs to the CC dehydroquinate synthase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR380959; CAG62820.1; -. DR GO; GO:0005737; C:cytoplasm; IEA. DR GO; GO:0003855; F:3-dehydroquinate dehydratase activity; IEA. DR GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA. DR GO; GO:0003866; F:3-phosphoshikimate 1-carboxyvinyltransferas...; IEA. DR GO; GO:0005524; F:ATP binding; IEA. DR GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA. DR GO; GO:0004765; F:shikimate kinase activity; IEA. DR GO; GO:0016089; P:aromatic amino acid family biosynthesis, sh...; IEA. DR InterPro; IPR006264; AroA_Ctransf. DR InterPro; IPR001381; DHquinase_I. DR InterPro; IPR002658; DHQ_synthase. DR InterPro; IPR001986; EPSP_synth. DR InterPro; IPR008289; Pentafunct_AroM. DR InterPro; IPR006151; Shikimate_DH. DR InterPro; IPR010110; Shik_DH_AROM. DR InterPro; IPR000623; Shik_kinase. DR Pfam; PF01487; DHquinase_I; 1. DR Pfam; PF01761; DHQ_synthase; 1. DR Pfam; PF00275; EPSP_synthase; 1. DR Pfam; PF01488; Shikimate_DH; 1. DR Pfam; PF01202; SKI; 1. DR PIRSF; PIRSF000514; Pentafunct_AroM; 1. DR PRINTS; PR01100; SHIKIMTKNASE. DR ProDom; PD005337; DHquinase_I; 1. DR ProDom; PD001867; EPSP_synth; 1. DR TIGRFAMs; TIGR01356; aroA; 1. DR TIGRFAMs; TIGR01357; aroB; 1. DR TIGRFAMs; TIGR01093; aroD; 1. DR TIGRFAMs; TIGR01809; Shik-DH-AROM; 1. DR PROSITE; PS01028; DEHYDROQUINASE_I; 1. DR PROSITE; PS00104; EPSP_SYNTHASE_1; 1. DR PROSITE; PS00885; EPSP_SYNTHASE_2; 1. DR PROSITE; PS01128; SHIKIMATE_KINASE; UNKNOWN_1. KW ATP-binding; Amino-acid biosynthesis; KW Aromatic amino acid biosynthesis; Complete proteome; Kinase; Lyase; KW Multifunctional enzyme; NADP; Oxidoreductase; Transferase. SQ SEQUENCE 1579 AA; 174230 MW; 51A302AA2AA7CCF8 CRC64; MLVKVPILGR ETIHVGYGVR SHIVETIVGL KSSTYVVIND SNVGRVPYFQ ELLSDFEAQL PAGSRLLRYV VKPGEANKTR ATKEQIEDYL LSEGCTRDTV IVAVGGGIIG DMIGYVAATF MRGVRVVQVP TSLLAMVDSS IGGKTAVDTP LGKNFIGAFW QPEFVLVDIK WLQSLPKREF INGMAEVIKT ACIWNADEFQ RLETHADEFL HVVNTPKISE KEGFQLYDTD IESIKEHIFK LVLESIKVKA EVVSSDERES SLRNLLNFGH SIGHAYEAIL TPQALHGECV SIGMVKEAEL SRYLGILSAT QVARLSKILV AYGLPVSKDE KWFRELTLNK KTPLDTLLKK MSIDKKNDGS KKKVVLLETI GKCYGKSAHV VSDEDLRFVL TDETLVYPFN NIPRDQNKTV TPPGSKSISN RALVLAALGK GTCRIKNLLH SDDTKHMLTA VQELKGANIS WEDNGETVVL EGQGGSTLVA CENDLYLGNA GTASRFLTSV AALVNSTSQK DHVILTGNAR MQQRPIGPLV DSLRNNGIKI DYVKNEGCLP LKVHTDSVFK GGRIELAATV SSQYVSSILM CAPYAENPVT LALVGGKPIS ILYVEMTIKM MEKFGIKVEK STTEEYTYII PKGHYVNPAE YVIESDASSA TYPLAFAALT GTTVTVPNIG SASLQGDARF ATDVLQPMGC SVTQTATSTT VTGPPVGHLK PLKHVDMEPM TDAFLTACVV AAVAHDNDPT SKNTTTIEGI ANQRVKECNR IEAMCTQLAK FGVRTNELPD GIQVHGLHSI NDLKVPSIGN EAVGVCTYDD HRVAMSFSLL AGMVNSEQPN SSNPTPVRIL ERHCTGKTWP GWWDVLHTEL GAQLDGAEPL ELNSMKNAKK SVVIIGMRAA GKTTISRWCA AALGYKLVDL DTLFEERYGH GMIKDFVSQH GWEKFREEEA RIFKEVIENY GDAGYVFSSG GGLVESSESR RILKSFSKSG GYVLHLHRDI EETIMFLQKD PTRPAYVEEI REVWNRRESW YKDCSNFSFF APHCNSEVEF QNLRRAFTKF IRTITGVTTV DIPTRRSAFV CLTFENLTEY TNSLKAITYG CDAVEVRVDH LSNMDEDFVS KQISILRAST DGLPIIFTVR TKKQGGKFPD EDYETLQKLL ITALKVGVDY IDLELTLPIG IQYKVLNMKR NTKIIGSHHD FASAYPWDHS EWENRYNQAL AMDVDIVKFV GMAKSFEDNL MLERFRDSHT TKPLIAINMG AHGRVSRVLN TILTPVTSEH LSEVAAPGQL TVAEINRIYT EMGGITKKDF FVVGSPIGHS RSPVLHNTGY SVLGLPHHFD KFETTSAEEV KKHLLDNKAN LGGLAVTIPL KLDIIKYMDE LTESAKVIGA VNTVIPLGNS KFKGDNTDWL GIRNSLVSNG VPESVSGLSG LVVGAGGTSR AAIFALHKLG CQKIFIVNRT TEKLEELVKF FPEEYNIVPI KEAEEAEAVN ETIGVAVNCV PADKPLDAKL ESLLERLLLK SSHTHFVSTL VEAAYKPSVT PVMKLAKDKY QWRVVPGAQM LVHQGVAQFE TWNNCRAPFK AIYDAVTEI //