ID H2A2A_HUMAN STANDARD; PRT; 129 AA. AC Q6FI13; P20670; DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot. DT 20-DEC-2005, sequence version 2. DT 07-MAR-2006, entry version 17. DE Histone H2A type 2-A (H2A.2). GN Name=HIST2H2AA; Synonyms=H2AFO; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=94235160; PubMed=8179821; RA Mannironi C., Orr A., Hatch C., Pilch D., Ivanova V., Bonner W.; RT "The relative expression of human histone H2A genes is similar in RT different types of proliferating cells."; RL DNA Cell Biol. 13:161-170(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=22296985; PubMed=12408966; DOI=10.1016/S0888-7543(02)96850-3; RA Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.; RT "The human and mouse replication-dependent histone genes."; RL Genomics 80:487-498(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Human chromosome 1 international sequencing consortium; RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). RN [6] RP PHOSPHORYLATION SITE THR-120. RX PubMed=15078818; DOI=10.1101/gad.1184604; RA Aihara H., Nakagawa T., Yasui K., Ohta T., Hirose S., Dhomae N., RA Takio K., Kaneko M., Takeshima Y., Muramatsu M., Ito T.; RT "Nucleosomal histone kinase-1 phosphorylates H2A Thr 119 during RT mitosis in the early Drosophila embryo."; RL Genes Dev. 18:877-888(2004). RN [7] RP ACETYLATION SITE SER-1, CITRULLINATION SITE ARG-3, AND MASS RP SPECTROMETRY. RX PubMed=15823041; DOI=10.1021/bi047505c; RA Hagiwara T., Hidaka Y., Yamada M.; RT "Deimination of histone H2A and H4 at arginine 3 in HL-60 RT granulocytes."; RL Biochemistry 44:5827-5834(2005). RN [8] RP IDENTIFICATION BY MASS SPECTROMETRY, ACETYLATION SITE LYS-5, AND RP PHOSPHORYLATION SITE SER-1. RX PubMed=16319397; DOI=10.1074/mcp.M500288-MCP200; RA Bonenfant D., Coulot M., Towbin H., Schindler P., van Oostrum J.; RT "Characterization of histones H2A and H2B variants and their RT post-translational modifications by mass spectrometry."; RL Mol. Cell. Proteomics 0:0-0(2005). CC -!- SUBUNIT: The nucleosome is an octamer containing two molecules CC each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 CC bp of DNA. CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- PTM: The chromatin-associated form is phosphorylated on Thr-120 CC during mitosis (Probable). CC -!- PTM: Deiminated on Arg-3 in granulocytes upon calcium entry. CC -!- SIMILARITY: Belongs to the histone H2A family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L19779; AAC24465.1; -; mRNA. DR EMBL; AY131971; AAN59957.1; -; Genomic_DNA. DR EMBL; CR536525; CAG38762.1; -; mRNA. DR EMBL; CR541872; CAG46670.1; -; mRNA. DR EMBL; AL591493; CAI12562.1; -; Genomic_DNA. DR EMBL; AL591493; CAI12565.1; -; Genomic_DNA. DR EMBL; BC001629; AAH01629.1; -; mRNA. DR EMBL; BC019308; AAH19308.1; -; mRNA. DR EMBL; BC096705; AAH96705.1; -; mRNA. DR EMBL; BC096739; AAH96739.1; -; mRNA. DR EMBL; BC098171; AAH98171.1; -; mRNA. DR PIR; S06742; S06742. DR HSSP; P06897; 1AOI. DR SMR; Q6FI13; 2-124. DR Ensembl; ENSG00000183558; Homo sapiens. DR H-InvDB; HIX0001003; -. DR HGNC; HGNC:4736; HIST2H2AA. DR MIM; 142720; gene. DR GO; GO:0000786; C:nucleosome; NAS. DR GO; GO:0003677; F:DNA binding; NAS. DR GO; GO:0007001; P:chromosome organization and biogenesis (sen...; NAS. DR GO; GO:0006334; P:nucleosome assembly; NAS. DR PROSITE; PS00046; HISTONE_H2A; 1. KW Acetylation; Chromosomal protein; Citrullination; DNA-binding; KW Nuclear protein; Nucleosome core; Phosphorylation; Ubl conjugation. FT INIT_MET 0 0 By similarity. FT CHAIN 1 129 Histone H2A type 2-A. FT /FTId=PRO_0000055232. FT MOD_RES 1 1 N-acetylserine. FT MOD_RES 1 1 Phosphoserine. FT MOD_RES 3 3 Citrulline. FT MOD_RES 5 5 N6-acetyllysine. FT MOD_RES 120 120 Phosphothreonine (Probable). FT CROSSLNK 119 119 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in ubiquitin) (By FT similarity). SQ SEQUENCE 129 AA; 13964 MW; CA97150A13FE8371 CRC64; SGRGKQGGKA RAKAKSRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY MAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK //