ID H2A2_HUMAN STANDARD; PRT; 129 AA. AC Q6FI13; P20670; DT 01-FEB-1991 (Rel. 17, Created) DT 01-FEB-1991 (Rel. 17, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Histone H2A type 2 (H2A.2). GN Name=HIST2H2AA; Synonyms=H2AFO; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=94235160; PubMed=8179821; RA Mannironi C., Orr A., Hatch C., Pilch D., Ivanova V., Bonner W.; RT "The relative expression of human histone H2A genes is similar in RT different types of proliferating cells."; RL DNA Cell Biol. 13:161-170(1994). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=22296985; PubMed=12408966; DOI=10.1016/S0888-7543(02)96850-3; RA Marzluff W.F., Gongidi P., Woods K.R., Jin J., Maltais L.J.; RT "The human and mouse replication-dependent histone genes."; RL Genomics 80:487-498(2002). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Human chromosome 1 international sequencing consortium; RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- SUBUNIT: The nucleosome is an octamer containing two molecules CC each of H2A, H2B, H3 and H4. The octamer wraps approximately 146 CC bp of DNA. CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: Belongs to the histone H2A family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L19779; AAC24465.1; -; mRNA. DR EMBL; AY131971; AAN59957.1; -; Genomic_DNA. DR EMBL; CR536525; CAG38762.1; -; mRNA. DR EMBL; CR541872; CAG46670.1; -; mRNA. DR EMBL; AL591493; CAI12562.1; -; Genomic_DNA. DR EMBL; AL591493; CAI12565.1; -; Genomic_DNA. DR EMBL; BC001629; AAH01629.1; -; mRNA. DR EMBL; BC019308; AAH19308.1; -; mRNA. DR EMBL; BC096705; AAH96705.1; -; mRNA. DR EMBL; BC096739; AAH96739.1; -; mRNA. DR EMBL; BC098171; AAH98171.1; -; mRNA. DR PIR; S06742; S06742. DR HSSP; P06897; 1AOI. DR SMR; P20670; 1-123. DR Ensembl; ENSG00000183558; Homo sapiens. DR HGNC; HGNC:4736; HIST2H2AA. DR H-InvDB; HIX0001003; -. DR MIM; 142720; -. DR GO; GO:0000786; C:nucleosome; NAS. DR GO; GO:0003677; F:DNA binding; NAS. DR GO; GO:0007001; P:chromosome organization and biogenesis (sen...; NAS. DR GO; GO:0006334; P:nucleosome assembly; NAS. DR InterPro; IPR007124; Hist_TAF. DR InterPro; IPR007125; Histone_core_D. DR InterPro; IPR002119; Histone_H2A. DR PANTHER; PTHR11611; Histone_H2A; 1. DR Pfam; PF00125; Histone; 1. DR PRINTS; PR00620; HISTONEH2A. DR ProDom; PD000522; Histone_H2A; 1. DR SMART; SM00414; H2A; 1. DR PROSITE; PS00046; HISTONE_H2A; 1. KW Acetylation; Chromosomal protein; DNA-binding; Multigene family; KW Nuclear protein; Nucleosome core; Ubl conjugation. FT INIT_MET 0 0 By similarity. FT MOD_RES 1 1 N-acetylserine (By similarity). FT MOD_RES 5 5 N6-acetyllysine (By similarity). FT MOD_RES 9 9 N6-acetyllysine (By similarity). FT CROSSLNK 119 119 Glycyl lysine isopeptide (Lys-Gly) FT (interchain with G-Cter in ubiquitin) (By FT similarity). SQ SEQUENCE 129 AA; 13964 MW; CA97150A13FE8371 CRC64; SGRGKQGGKA RAKAKSRSSR AGLQFPVGRV HRLLRKGNYA ERVGAGAPVY MAAVLEYLTA EILELAGNAA RDNKKTRIIP RHLQLAIRND EELNKLLGKV TIAQGGVLPN IQAVLLPKKT ESHHKAKGK //