ID Q6FHW6_HUMAN Unreviewed; 557 AA. AC Q6FHW6; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 28-NOV-2012, entry version 77. DE SubName: Full=TCF2 protein; DE SubName: Full=Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor; DE SubName: Full=Transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor, isoform CRA_b; DE SubName: Full=cDNA FLJ76233, highly similar to Homo sapiens transcription factor 2, hepatic; LF-B3; variant hepatic nuclear factor (TCF2), transcript variant a, mRNA; GN Name=TCF2; ORFNames=hCG_27684; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) System Donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE. RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Thalamus; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., RA Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., RA Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M., RA Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BT007126; AAP35790.1; -; mRNA. DR EMBL; AK290131; BAF82820.1; -; mRNA. DR EMBL; CR536572; CAG38809.1; -; mRNA. DR EMBL; CH471199; EAW57603.1; -; Genomic_DNA. DR IPI; IPI00020078; -. DR RefSeq; NP_000449.1; NM_000458.2. DR UniGene; Hs.191144; -. DR ProteinModelPortal; Q6FHW6; -. DR SMR; Q6FHW6; 1-32, 91-325. DR STRING; Q6FHW6; -. DR PRIDE; Q6FHW6; -. DR DNASU; 6928; -. DR GeneID; 6928; -. DR KEGG; hsa:6928; -. DR CTD; 6928; -. DR PharmGKB; PA162391083; -. DR HOVERGEN; HBG005980; -. DR KO; K08034; -. DR OMA; THKQEPP; -. DR PhylomeDB; Q6FHW6; -. DR GenomeRNAi; 6928; -. DR NextBio; 27109; -. DR ArrayExpress; Q6FHW6; -. DR Bgee; Q6FHW6; -. DR GO; GO:0005634; C:nucleus; IDA:HPA. DR GO; GO:0005667; C:transcription factor complex; IEA:Compara. DR GO; GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IEA:Compara. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0044212; F:transcription regulatory region DNA binding; IEA:Compara. DR GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Compara. DR GO; GO:0048754; P:branching morphogenesis of a tube; IEA:Compara. DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Compara. DR GO; GO:0001714; P:endodermal cell fate specification; IEA:Compara. DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Compara. DR GO; GO:0061017; P:hepatoblast differentiation; IEA:Compara. DR GO; GO:0030902; P:hindbrain development; IEA:Compara. DR GO; GO:0001826; P:inner cell mass cell differentiation; IEA:Compara. DR GO; GO:0030073; P:insulin secretion; IEA:Compara. DR GO; GO:0072181; P:mesonephric duct formation; IEA:Compara. DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Compara. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara. DR GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. DR GO; GO:0072095; P:regulation of branch elongation involved in ureteric bud branching; IEA:Compara. DR GO; GO:0042663; P:regulation of endodermal cell fate specification; IEA:Compara. DR GO; GO:0030111; P:regulation of Wnt receptor signaling pathway; IEA:Compara. DR GO; GO:0009749; P:response to glucose stimulus; IEA:Compara. DR GO; GO:0060677; P:ureteric bud elongation; IEA:Compara. DR Gene3D; 1.10.260.40; G3DSA:1.10.260.40; 1. DR Gene3D; 1.10.10.60; Homeodomain-rel; 1. DR InterPro; IPR006899; HNF-1_N. DR InterPro; IPR023219; HNF1_dimer_dom. DR InterPro; IPR006897; HNF1b_C. DR InterPro; IPR001356; Homeodomain. DR InterPro; IPR009057; Homeodomain-like. DR InterPro; IPR010982; Lambda_DNA-bd_dom. DR Pfam; PF04814; HNF-1_N; 1. DR Pfam; PF04812; HNF-1B_C; 1. DR Pfam; PF00046; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF100957; HNF1_dimer_dom; 1. DR SUPFAM; SSF46689; Homeodomain_like; 1. DR SUPFAM; SSF47413; Lambda_like_DNA; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 2: Evidence at transcript level; KW DNA-binding; Homeobox; Nucleus. SQ SEQUENCE 557 AA; 61324 MW; 9E1ECC7423B73980 CRC64; MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPNFG VKLETLPLSP GSGAEPDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQSHGPGQSD DACSEPTNKK MRRNRFKWGP ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHGSPHHQPS SSPPNKLSGV RYSQQGNNEI TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG KMISVSGGGL PPVSTLTNIH SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS PHQQPLMQQS PGSHMAQQPF MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI STLTNMSSSK QCPLQAW //