ID Q6FHW6_HUMAN PRELIMINARY; PRT; 557 AA. AC Q6FHW6; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 18-APR-2006, entry version 13. DE TCF2 protein (Transcription factor 2, hepatic; LF-B3; variant hepatic DE nuclear factor). GN Name=TCF2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., RA Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., RA Korn B., Zuo D., Hu Y., LaBaer J.; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) System Donor RT vector."; RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR536572; CAG38809.1; -; mRNA. DR EMBL; BT007126; AAP35790.1; -; mRNA. DR UniGene; Hs.191144; -. DR Ensembl; ENSG00000108753; Homo sapiens. DR GO; GO:0005634; C:nucleus; IEA. DR GO; GO:0003700; F:transcription factor activity; IEA. DR GO; GO:0016563; F:transcriptional activator activity; IEA. DR GO; GO:0045941; P:positive regulation of transcription; IEA. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA. DR InterPro; IPR006899; HNF-1_N. DR InterPro; IPR006897; HNF1b_C. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR009057; Homeodomain_like. DR InterPro; IPR010982; Lambda_DNA_bd. DR InterPro; IPR010981; SinR_like_dimer. DR Pfam; PF04814; HNF-1_N; 1. DR Pfam; PF04812; HNF-1B_C; 1. DR Pfam; PF00046; Homeobox; 1. DR SMART; SM00389; HOX; 1. DR PROSITE; PS00027; HOMEOBOX_1; UNKNOWN_1. DR PROSITE; PS50071; HOMEOBOX_2; 1. KW DNA-binding; Homeobox; Nuclear protein; Transcription; KW Transcription regulation. SQ SEQUENCE 557 AA; 61324 MW; 9E1ECC7423B73980 CRC64; MVSKLTSLQQ ELLSALLSSG VTKEVLVQAL EELLPSPNFG VKLETLPLSP GSGAEPDTKP VFHTLTNGHA KGRLSGDEGS EDGDDYDTPP ILKELQALNT EEAAEQRAEV DRMLSEDPWR AAKMIKGYMQ QHNIPQREVV DVTGLNQSHL SQHLNKGTPM KTQKRAALYT WYVRKQREIL RQFNQTVQSS GNMTDKSSQD QLLFLFPEFS QQSHGPGQSD DACSEPTNKK MRRNRFKWGP ASQQILYQAY DRQKNPSKEE REALVEECNR AECLQRGVSP SKAHGLGSNL VTEVRVYNWF ANRRKEEAFR QKLAMDAYSS NQTHSLNPLL SHGSPHHQPS SSPPNKLSGV RYSQQGNNEI TSSSTISHHG NSAMVTSQSV LQQVSPASLD PGHNLLSPDG KMISVSGGGL PPVSTLTNIH SLSHHNPQQS QNLIMTPLSG VMAIAQSLNT SQAQSVPVIN SVAGSLAALQ PVQFSQQLHS PHQQPLMQQS PGSHMAQQPF MAAVTQLQNS HMYAHKQEPP QYSHTSRFPS AMVVTDTSSI STLTNMSSSK QCPLQAW //