ID Q6EXB0_HUMAN PRELIMINARY; PRT; 365 AA. AC Q6EXB0; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 07-FEB-2006, entry version 9. DE MHC class I antigen precursor. GN Name=HLA-A; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHH-006933; RA Elsner H.A., Bernard G., Bernard A., Blasczyk R.; RT "The non-expression of A*2901N is caused by a defect splicing site in RT intron 4."; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Beta-2-microglobulin is the beta-chain of major CC histocompatibility complex class I molecules (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ303359; CAC27518.1; -; Genomic_DNA. DR SMR; Q6EXB0; 25-299. DR Ensembl; ENSG00000197499; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0042612; C:MHC class I protein complex; IEA. DR GO; GO:0030106; F:MHC class I receptor activity; IEA. DR GO; GO:0019883; P:antigen presentation, endogenous antigen; IEA. DR GO; GO:0019885; P:antigen processing, endogenous antigen via ...; IEA. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003597; Ig_c1. DR InterPro; IPR003006; Ig_MHC. DR InterPro; IPR001039; MHC_I_alpha_A1A2. DR InterPro; IPR010579; MHC_I_alpha_C. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. KW Immune response; Immunoglobulin domain; Signal; Transmembrane. FT SIGNAL 1 25 Potential. FT CHAIN 25 365 MHC class I antigen. SQ SEQUENCE 365 AA; 40863 MW; 56E4B9039B3C783C CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV //