ID Q6EXB0_HUMAN Unreviewed; 365 AA. AC Q6EXB0; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 28-JUN-2023, entry version 150. DE SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CAC27518.1}; DE SubName: Full=MHC class I protein {ECO:0000313|EMBL:QAX33598.1}; GN Name=HLA-A {ECO:0000313|EMBL:CAC27518.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAC27518.1}; RN [1] {ECO:0000313|EMBL:CAC27518.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=MHH-006933 {ECO:0000313|EMBL:CAC27518.1}; RA Elsner H.A., Bernard G., Bernard A., Blasczyk R.; RT "The non-expression of A*2901N is caused by a defect splicing site in RT intron 4."; RL Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ACA34997.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19735485; DOI=10.1111/j.1744-313X.2009.00874.x; RA Zhu F., He Y., Zhang W., He J., He J., Xu X., Yan L.; RT "Analysis of the complete genomic sequence of HLA-A alleles in the Chinese RT Han population."; RL Int. J. Immunogenet. 36:351-360(2009). RN [3] {ECO:0000313|EMBL:ADI95502.1} RP NUCLEOTIDE SEQUENCE. RA Xu Y., Deng Z., Yang B.; RT "Characterization and polymorphism analyses of HLA-A genomic full length in RT Chinese Han population."; RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|EMBL:CUX96943.1} RP NUCLEOTIDE SEQUENCE. RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.; RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases. RN [5] {ECO:0000313|EMBL:CUX96943.1} RP NUCLEOTIDE SEQUENCE. RA Marsh S.G.E.; RT "Full-length genomic HLA sequences."; RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases. RN [6] {ECO:0000313|EMBL:QAX33598.1} RP NUCLEOTIDE SEQUENCE. RA Balz V., Krause S., Enczmann J.; RT "New HLA class 1 alleles."; RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases. RN [7] {ECO:0000313|EMBL:QDK62349.1} RP NUCLEOTIDE SEQUENCE. RA Cereb N., Yang S.Y.; RT "HLA new alleles found by Histogenetics."; RL Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:VVT62749.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.; RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the MHC class I family. CC {ECO:0000256|RuleBase:RU004439}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; EU445477; ACA34997.1; -; Genomic_DNA. DR EMBL; HM357874; ADI95502.1; -; Genomic_DNA. DR EMBL; MH294657; AWM62316.1; -; Genomic_DNA. DR EMBL; MH721209; AXN55435.1; -; Genomic_DNA. DR EMBL; AJ303359; CAC27518.1; -; Genomic_DNA. DR EMBL; LN999852; CUX96943.1; -; Genomic_DNA. DR EMBL; MH269338; QAX33598.1; -; Genomic_DNA. DR EMBL; MK843993; QCQ67047.1; -; Genomic_DNA. DR EMBL; MK938134; QDK61730.1; -; Genomic_DNA. DR EMBL; MK938148; QDK61744.1; -; Genomic_DNA. DR EMBL; MK954864; QDK61796.1; -; Genomic_DNA. DR EMBL; MK954881; QDK61812.1; -; Genomic_DNA. DR EMBL; MK954923; QDK61854.1; -; Genomic_DNA. DR EMBL; MK955002; QDK61932.1; -; Genomic_DNA. DR EMBL; MK955042; QDK61972.1; -; Genomic_DNA. DR EMBL; MK955094; QDK62022.1; -; Genomic_DNA. DR EMBL; MN016102; QDK62349.1; -; Genomic_DNA. DR EMBL; MN016137; QDK62383.1; -; Genomic_DNA. DR EMBL; MN787227; QGY64024.1; -; Genomic_DNA. DR EMBL; MN787240; QGY64037.1; -; Genomic_DNA. DR EMBL; MN787258; QGY64054.1; -; Genomic_DNA. DR EMBL; MN787279; QGY64075.1; -; Genomic_DNA. DR EMBL; MN812895; QGY64089.1; -; Genomic_DNA. DR EMBL; MT015534; QIA48956.1; -; Genomic_DNA. DR EMBL; MT503593; QMI58397.1; -; Genomic_DNA. DR EMBL; MT514434; QMI58424.1; -; Genomic_DNA. DR EMBL; MT681805; QMI58539.1; -; Genomic_DNA. DR EMBL; LR702001; VVT62749.1; -; Genomic_DNA. DR AlphaFoldDB; Q6EXB0; -. DR SMR; Q6EXB0; -. DR PeptideAtlas; Q6EXB0; -. DR ChiTaRS; HLA-A; human. DR GO; GO:0009986; C:cell surface; IEA:UniProt. DR GO; GO:0031901; C:early endosome membrane; IEA:UniProt. DR GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt. DR GO; GO:0098553; C:lumenal side of endoplasmic reticulum membrane; IEA:UniProt. DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW. DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt. DR GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR CDD; cd21027; IgC1_MHC_Ia_HLA-A; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011161; MHC_I-like_Ag-recog. DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR001039; MHC_I_a_a1/a2. DR InterPro; IPR010579; MHC_I_a_C. DR PANTHER; PTHR16675:SF229; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN; 1. DR PANTHER; PTHR16675; MHC CLASS I-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00129; MHC_I; 1. DR Pfam; PF06623; MHC_I_C; 1. DR PRINTS; PR01638; MHCCLASSI. DR SMART; SM00407; IGc1; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..24 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 25..365 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5015098266" FT TRANSMEM 306..330 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 209..295 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT REGION 338..365 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 341..359 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 365 AA; 40863 MW; 56E4B9039B3C783C CRC64; MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL TACKV //