ID   Q6EXB0_HUMAN            Unreviewed;       365 AA.
AC   Q6EXB0;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   22-FEB-2023, entry version 148.
DE   SubName: Full=MHC class I antigen {ECO:0000313|EMBL:CAC27518.1};
DE   SubName: Full=MHC class I protein {ECO:0000313|EMBL:QAX33598.1};
GN   Name=HLA-A {ECO:0000313|EMBL:CAC27518.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAC27518.1};
RN   [1] {ECO:0000313|EMBL:CAC27518.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=MHH-006933 {ECO:0000313|EMBL:CAC27518.1};
RA   Elsner H.A., Bernard G., Bernard A., Blasczyk R.;
RT   "The non-expression of A*2901N is caused by a defect splicing site in
RT   intron 4.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ACA34997.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=19735485; DOI=10.1111/j.1744-313X.2009.00874.x;
RA   Zhu F., He Y., Zhang W., He J., He J., Xu X., Yan L.;
RT   "Analysis of the complete genomic sequence of HLA-A alleles in the Chinese
RT   Han population.";
RL   Int. J. Immunogenet. 36:351-360(2009).
RN   [3] {ECO:0000313|EMBL:ADI95502.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu Y., Deng Z., Yang B.;
RT   "Characterization and polymorphism analyses of HLA-A genomic full length in
RT   Chinese Han population.";
RL   Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CUX96943.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:CUX96943.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Marsh S.G.E.;
RT   "Full-length genomic HLA sequences.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:QAX33598.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Balz V., Krause S., Enczmann J.;
RT   "New HLA class 1 alleles.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:QDK62349.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Cereb N., Yang S.Y.;
RT   "HLA new alleles found by Histogenetics.";
RL   Submitted (JUN-2019) to the EMBL/GenBank/DDBJ databases.
RN   [8] {ECO:0000313|EMBL:VVT62749.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.;
RL   Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the MHC class I family.
CC       {ECO:0000256|RuleBase:RU004439}.
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DR   EMBL; EU445477; ACA34997.1; -; Genomic_DNA.
DR   EMBL; HM357874; ADI95502.1; -; Genomic_DNA.
DR   EMBL; MH294657; AWM62316.1; -; Genomic_DNA.
DR   EMBL; MH721209; AXN55435.1; -; Genomic_DNA.
DR   EMBL; AJ303359; CAC27518.1; -; Genomic_DNA.
DR   EMBL; LN999852; CUX96943.1; -; Genomic_DNA.
DR   EMBL; MH269338; QAX33598.1; -; Genomic_DNA.
DR   EMBL; MK843993; QCQ67047.1; -; Genomic_DNA.
DR   EMBL; MK938134; QDK61730.1; -; Genomic_DNA.
DR   EMBL; MK938148; QDK61744.1; -; Genomic_DNA.
DR   EMBL; MK954864; QDK61796.1; -; Genomic_DNA.
DR   EMBL; MK954881; QDK61812.1; -; Genomic_DNA.
DR   EMBL; MK954923; QDK61854.1; -; Genomic_DNA.
DR   EMBL; MK955002; QDK61932.1; -; Genomic_DNA.
DR   EMBL; MK955042; QDK61972.1; -; Genomic_DNA.
DR   EMBL; MK955094; QDK62022.1; -; Genomic_DNA.
DR   EMBL; MN016102; QDK62349.1; -; Genomic_DNA.
DR   EMBL; MN016137; QDK62383.1; -; Genomic_DNA.
DR   EMBL; MN787227; QGY64024.1; -; Genomic_DNA.
DR   EMBL; MN787240; QGY64037.1; -; Genomic_DNA.
DR   EMBL; MN787258; QGY64054.1; -; Genomic_DNA.
DR   EMBL; MN787279; QGY64075.1; -; Genomic_DNA.
DR   EMBL; MN812895; QGY64089.1; -; Genomic_DNA.
DR   EMBL; MT015534; QIA48956.1; -; Genomic_DNA.
DR   EMBL; MT503593; QMI58397.1; -; Genomic_DNA.
DR   EMBL; MT514434; QMI58424.1; -; Genomic_DNA.
DR   EMBL; MT681805; QMI58539.1; -; Genomic_DNA.
DR   EMBL; LR702001; VVT62749.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6EXB0; -.
DR   SMR; Q6EXB0; -.
DR   PeptideAtlas; Q6EXB0; -.
DR   ChiTaRS; HLA-A; human.
DR   GO; GO:0009986; C:cell surface; IEA:UniProt.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProt.
DR   GO; GO:0012507; C:ER to Golgi transport vesicle membrane; IEA:UniProt.
DR   GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProt.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0055038; C:recycling endosome membrane; IEA:UniProt.
DR   GO; GO:0019882; P:antigen processing and presentation; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   CDD; cd07698; IgC_MHC_I_alpha3; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.500.10; MHC class I-like antigen recognition-like; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011161; MHC_I-like_Ag-recog.
DR   InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR001039; MHC_I_a_a1/a2.
DR   InterPro; IPR010579; MHC_I_a_C.
DR   PANTHER; PTHR16675:SF229; HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A ALPHA CHAIN; 1.
DR   PANTHER; PTHR16675; MHC CLASS I-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00129; MHC_I; 1.
DR   Pfam; PF06623; MHC_I_C; 1.
DR   PRINTS; PR01638; MHCCLASSI.
DR   SMART; SM00407; IGc1; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           25..365
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5015098266"
FT   TRANSMEM        306..330
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          209..295
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          338..365
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   365 AA;  40863 MW;  56E4B9039B3C783C CRC64;
     MAVMAPRTLL LLLLGALALT QTWAGSHSMR YFTTSVSRPG RGEPRFIAVG YVDDTQFVRF
     DSDAASQRME PRAPWIEQEG PEYWDLQTRN VKAQSQTDRA NLGTLRGYYN QSEAGSHTIQ
     MMYGCHVGSD GRFLRGYRQD AYDGKDYIAL NEDLRSWTAA DMAAQITQRK WEAARVAEQL
     RAYLEGTCVE WLRRYLENGK ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT
     WQRDGEDQTQ DTELVETRPA GDGTFQKWAS VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
     SSQPTIPIVG IIAGLVLFGA VFAGAVVAAV RWRRKSSDRK GGSYSQAASS DSAQGSDMSL
     TACKV
//