ID Q6E3U7_9INFA Unreviewed; 228 AA. AC Q6E3U7; DT 16-AUG-2004, integrated into UniProtKB/TrEMBL. DT 16-AUG-2004, sequence version 1. DT 11-MAY-2016, entry version 58. DE RecName: Full=Non-structural protein 1 {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00141112}; DE Short=NS1 {ECO:0000256|RuleBase:RU362113}; DE Flags: Fragment; GN Name=NS1 {ECO:0000313|EMBL:AAT12106.1}; GN Synonyms=NS {ECO:0000256|RuleBase:RU362113}; OS Influenza A virus (A/duck/Fujian/01/2002(H5N1)). OC Viruses; ssRNA viruses; ssRNA negative-strand viruses; OC Orthomyxoviridae; Influenzavirus A. OX NCBI_TaxID=274827 {ECO:0000313|EMBL:AAT12106.1}; RN [1] {ECO:0000313|EMBL:AAT12106.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Duck/Fujian/01/2002 {ECO:0000313|EMBL:AAT12106.1}; RX PubMed=15235128; DOI=10.1073/pnas.0403212101; RA Chen H., Deng G., Li Z., Tian G., Li Y., Jiao P., Zhang L., Liu Z., RA Webster R.G., Yu K.; RT "The evolution of H5N1 influenza viruses in ducks in southern China."; RL Proc. Natl. Acad. Sci. U.S.A. 101:10452-10457(2004). RN [2] {ECO:0000313|EMBL:AAT12106.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/Duck/Fujian/01/2002 {ECO:0000313|EMBL:AAT12106.1}; RA Chen H.L., Deng G.H., Li Z.J., Tian G.B., Li Y.B., Jiao P., Zhang L., RA Webster R.G., Yu K.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. CC -!- SUBUNIT: Homodimer. Interacts with host TRIM25 (via coiled coil); CC this interaction specifically inhibits TRIM25 multimerization and CC TRIM25-mediated DDX58 CARD ubiquitination. Interacts with human CC EIF2AK2/PKR, CPSF4, IVNS1ABP and PABPN1. CC {ECO:0000256|RuleBase:RU362113}. CC -!- SUBCELLULAR LOCATION: Host cytoplasm CC {ECO:0000256|SAAS:SAAS00596549}. CC -!- DOMAIN: The dsRNA-binding region is required for suppression of CC RNA silencing. {ECO:0000256|RuleBase:RU362113}. CC -!- SIMILARITY: Belongs to the influenza A viruses NS1 family. CC {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00596488}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY585441; AAT12106.1; -; mRNA. DR ProteinModelPortal; Q6E3U7; -. DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW. DR GO; GO:0039524; P:suppression by virus of host mRNA processing; IEA:UniProtKB-KW. DR GO; GO:0039580; P:suppression by virus of host PKR activity; IEA:UniProtKB-KW. DR GO; GO:0039540; P:suppression by virus of host RIG-I activity; IEA:UniProtKB-KW. DR GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW. DR Gene3D; 1.10.287.10; -; 1. DR InterPro; IPR000256; Flu_NS1. DR InterPro; IPR009068; S15_NS1_RNA-bd. DR Pfam; PF00600; Flu_NS1; 1. DR SUPFAM; SSF47060; SSF47060; 1. PE 2: Evidence at transcript level; KW Eukaryotic host gene expression shutoff by virus KW {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00490754}; KW Host cytoplasm {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00491311}; KW Host gene expression shutoff by virus {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00490948}; KW Host mRNA suppression by virus {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00491234}; KW Host nucleus {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00491032}; KW Host-virus interaction {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00491141}; KW Inhibition of host innate immune response by virus KW {ECO:0000256|SAAS:SAAS00491089}; KW Inhibition of host interferon signaling pathway by virus KW {ECO:0000256|SAAS:SAAS00490748}; KW Inhibition of host PKR by virus {ECO:0000256|SAAS:SAAS00491222}; KW Inhibition of host pre-mRNA processing by virus KW {ECO:0000256|RuleBase:RU362113, ECO:0000256|SAAS:SAAS00491387}; KW Inhibition of host RIG-I by virus {ECO:0000256|SAAS:SAAS00491268}; KW Inhibition of host RLR pathway by virus KW {ECO:0000256|SAAS:SAAS00491356}; KW Interferon antiviral system evasion {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00490884}; KW RNA-binding {ECO:0000256|RuleBase:RU362113, KW ECO:0000256|SAAS:SAAS00491002}; KW Viral immunoevasion {ECO:0000256|SAAS:SAAS00491222}. FT NON_TER 228 228 {ECO:0000313|EMBL:AAT12106.1}. SQ SEQUENCE 228 AA; 25969 MW; 073C0B09E174938A CRC64; MDSNTVSSFQ VDCFLWHVRK RFADQELGDA PFLDRLRRDQ KSLRGRGSTL GLDIETATRA GKQIVERILE EESDEALKMT IASLPAPRYL TEMTIEEMTR DWYMLMPRQK VTGSLWVRMD QAIMDKTIIF KANFSVIFDR LETLIPLRAF TEGGAIVGEI SPLPSVPGHT NEDVKNAIGV LIGGLEWNDN TVRVSETLQR FAWRSSDEDG RPPLPPKQKR KMARTIES //