ID   DMKN_HUMAN              Reviewed;         476 AA.
AC   Q6E0U4; A3EZ79; A3EZ80; A3EZ81; A3EZ82; A3EZ83; C9J4P6; C9J5N8; C9JAL3;
AC   Q32W58; Q32W62; Q32W63; Q32W64; Q32W65; Q32W66; Q32W67; Q6E0U5; Q6UXC7;
AC   Q96EW8; Q9BSY6;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 3.
DT   29-SEP-2021, entry version 144.
DE   RecName: Full=Dermokine;
DE   AltName: Full=Epidermis-specific secreted protein SK30/SK89;
DE   Flags: Precursor;
GN   Name=DMKN; ORFNames=UNQ729/PRO1411;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
RP   (ISOFORM 15), PROTEIN SEQUENCE OF 22-26, SUBCELLULAR LOCATION, AND VARIANTS
RP   ALA-91 AND ALA-427.
RX   PubMed=15234001; DOI=10.1016/j.ygeno.2004.03.010;
RA   Matsui T., Hayashi-Kisumi F., Kinoshita Y., Katahira S., Morita K.,
RA   Miyachi Y., Ono Y., Imai T., Tanigawa Y., Komiya T., Tsukita S.;
RT   "Identification of novel keratinocyte-secreted peptides dermokine-alpha/-
RT   beta and a new stratified epithelium-secreted protein gene complex on human
RT   chromosome 19q13.1.";
RL   Genomics 84:384-397(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 3; 5; 9; 10; 11; 12; 13 AND 14),
RP   PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 15), TISSUE SPECIFICITY, AND
RP   VARIANTS ALA-91 AND ALA-427.
RC   TISSUE=Epidermis;
RX   PubMed=16374476; DOI=10.1038/sj.jid.5700033;
RA   Toulza E., Galliano M.F., Jonca N., Gallinaro H., Mechin M.C.,
RA   Ishida-Yamamoto A., Serre G., Guerrin M.;
RT   "The human dermokine gene: description of novel isoforms with different
RT   tissue-specific expression and subcellular location.";
RL   J. Invest. Dermatol. 126:503-506(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4; 7 AND 8), TISSUE SPECIFICITY,
RP   GLYCOSYLATION, SUBUNIT, AND VARIANTS ALA-91; SER-280 AND ALA-427.
RX   PubMed=17380110; DOI=10.1038/sj.jid.5700779;
RA   Naso M.F., Liang B., Huang C.C., Song X.-Y., Shahied-Arruda L.,
RA   Belkowski S.M., D'Andrea M.R., Polkovitch D.A., Lawrence D.R.,
RA   Griswold D.E., Sweet R.W., Amegadzie B.Y.;
RT   "Dermokine: an extensively differentially spliced gene expressed in
RT   epithelial cells.";
RL   J. Invest. Dermatol. 127:1622-1631(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), AND VARIANTS ALA-91 AND
RP   SER-139.
RX   PubMed=12975309; DOI=10.1101/gr.1293003;
RA   Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA   Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA   Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA   Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA   Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA   Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA   Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA   Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT   "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT   identify novel human secreted and transmembrane proteins: a bioinformatics
RT   assessment.";
RL   Genome Res. 13:2265-2270(2003).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 14), AND VARIANTS
RP   ALA-91 AND ALA-427.
RC   TISSUE=Skin, and Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [7]
RP   VARIANT [LARGE SCALE ANALYSIS] ASP-13.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA   Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA   Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA   Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA   Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: May act as a soluble regulator of keratinocyte
CC       differentiation. {ECO:0000305}.
CC   -!- SUBUNIT: Homooligomer. Seems to be able to homodimerize and
CC       homotrimerize. {ECO:0000269|PubMed:17380110}.
CC   -!- INTERACTION:
CC       Q6E0U4; P46379-2: BAG6; NbExp=3; IntAct=EBI-7943171, EBI-10988864;
CC       Q6E0U4; Q05329: GAD2; NbExp=3; IntAct=EBI-7943171, EBI-9304251;
CC       Q6E0U4; P11021: HSPA5; NbExp=3; IntAct=EBI-7943171, EBI-354921;
CC       Q6E0U4; O43765: SGTA; NbExp=3; IntAct=EBI-7943171, EBI-347996;
CC       Q6E0U4; Q96EQ0: SGTB; NbExp=3; IntAct=EBI-7943171, EBI-744081;
CC       Q6E0U4; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-7943171, EBI-741480;
CC       Q6E0U4; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-7943171, EBI-947187;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15234001}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=16;
CC       Name=1; Synonyms=Dermokine beta;
CC         IsoId=Q6E0U4-1; Sequence=Displayed;
CC       Name=2; Synonyms=Dermokine beta-2;
CC         IsoId=Q6E0U4-2; Sequence=VSP_033093;
CC       Name=3; Synonyms=Dermokine-gamma 1, Dermokine gamma-2;
CC         IsoId=Q6E0U4-3; Sequence=VSP_033103, VSP_033104;
CC       Name=4; Synonyms=Dermokine beta-1;
CC         IsoId=Q6E0U4-4; Sequence=VSP_033094, VSP_033100, VSP_033106;
CC       Name=5; Synonyms=Dermokine gamma-2;
CC         IsoId=Q6E0U4-5; Sequence=VSP_033101, VSP_033103, VSP_033104;
CC       Name=6;
CC         IsoId=Q6E0U4-6; Sequence=VSP_033102;
CC       Name=7; Synonyms=Dermokine gamma-1;
CC         IsoId=Q6E0U4-7; Sequence=VSP_033098, VSP_033103, VSP_033104;
CC       Name=8; Synonyms=Dermokine delta;
CC         IsoId=Q6E0U4-8; Sequence=VSP_033092, VSP_033095;
CC       Name=9; Synonyms=Dermokine-delta-4;
CC         IsoId=Q6E0U4-9; Sequence=VSP_033091, VSP_033096;
CC       Name=10; Synonyms=Dermokine-delta-1;
CC         IsoId=Q6E0U4-10; Sequence=VSP_033090, VSP_033097;
CC       Name=11; Synonyms=Dermokine-delta-3;
CC         IsoId=Q6E0U4-11; Sequence=VSP_033089, VSP_033099;
CC       Name=12; Synonyms=Dermokine-delta-2;
CC         IsoId=Q6E0U4-12; Sequence=VSP_033089, VSP_033099, VSP_033106;
CC       Name=13; Synonyms=Dermokine-delta-6;
CC         IsoId=Q6E0U4-13; Sequence=VSP_033088;
CC       Name=14; Synonyms=Dermokine-delta-5;
CC         IsoId=Q6E0U4-14; Sequence=VSP_033088, VSP_033106;
CC       Name=15; Synonyms=Dermokine-alpha;
CC         IsoId=Q6E0U4-15; Sequence=VSP_033087, VSP_033105;
CC       Name=16;
CC         IsoId=Q6E0U4-16; Sequence=VSP_033094, VSP_047249;
CC   -!- TISSUE SPECIFICITY: Expressed in epidermis; in the spinous and granular
CC       layers and in placenta. Also found in the epithelia of the small
CC       intestine, macrophages of the lung and endothelial cells of the lung.
CC       Isoform 15 is expressed in epidermis and placenta. Isoform 1 is
CC       expressed in epidermis. {ECO:0000269|PubMed:16374476,
CC       ECO:0000269|PubMed:17380110}.
CC   -!- PTM: O-glycosylated. {ECO:0000269|PubMed:17380110}.
CC   -!- SIMILARITY: Belongs to the dermokine family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX48757.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY622964; AAT68268.1; -; mRNA.
DR   EMBL; AY622965; AAT68269.1; -; mRNA.
DR   EMBL; AY789695; AAX48745.1; -; mRNA.
DR   EMBL; AY789696; AAX48746.1; -; mRNA.
DR   EMBL; AY789697; AAX48747.1; -; mRNA.
DR   EMBL; AY789698; AAX48748.1; -; mRNA.
DR   EMBL; AY789699; AAX48749.1; -; mRNA.
DR   EMBL; AY789700; AAX48750.1; -; mRNA.
DR   EMBL; AY789701; AAX48751.1; -; mRNA.
DR   EMBL; AY789702; AAX48752.1; -; mRNA.
DR   EMBL; AY789703; AAX48753.1; -; mRNA.
DR   EMBL; AY789704; AAX48754.1; -; mRNA.
DR   EMBL; AY789705; AAX48755.1; -; mRNA.
DR   EMBL; AY789706; AAX48756.1; -; mRNA.
DR   EMBL; AY789707; AAX48757.1; ALT_INIT; mRNA.
DR   EMBL; EF158319; ABN11271.1; -; mRNA.
DR   EMBL; EF158320; ABN11272.1; -; mRNA.
DR   EMBL; EF158321; ABN11273.1; -; mRNA.
DR   EMBL; EF158322; ABN11274.1; -; mRNA.
DR   EMBL; EF158323; ABN11275.1; -; mRNA.
DR   EMBL; AY358412; AAQ88778.1; -; mRNA.
DR   EMBL; AC138125; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AD001502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC004493; AAH04493.2; -; mRNA.
DR   EMBL; BC011886; AAH11886.1; -; mRNA.
DR   EMBL; BC035311; AAH35311.1; -; mRNA.
DR   CCDS; CCDS12463.1; -. [Q6E0U4-1]
DR   CCDS; CCDS42549.1; -. [Q6E0U4-15]
DR   CCDS; CCDS46051.1; -. [Q6E0U4-8]
DR   CCDS; CCDS46052.1; -. [Q6E0U4-3]
DR   CCDS; CCDS46053.1; -. [Q6E0U4-5]
DR   CCDS; CCDS46054.2; -. [Q6E0U4-16]
DR   CCDS; CCDS54250.1; -. [Q6E0U4-4]
DR   CCDS; CCDS54251.1; -. [Q6E0U4-7]
DR   CCDS; CCDS54252.1; -. [Q6E0U4-6]
DR   CCDS; CCDS86745.1; -. [Q6E0U4-13]
DR   RefSeq; NP_001119528.2; NM_001126056.2. [Q6E0U4-16]
DR   RefSeq; NP_001119529.2; NM_001126057.2. [Q6E0U4-5]
DR   RefSeq; NP_001119530.2; NM_001126058.2. [Q6E0U4-3]
DR   RefSeq; NP_001119531.1; NM_001126059.2. [Q6E0U4-8]
DR   RefSeq; NP_001177276.1; NM_001190347.1. [Q6E0U4-4]
DR   RefSeq; NP_001177277.1; NM_001190348.1. [Q6E0U4-6]
DR   RefSeq; NP_001177278.1; NM_001190349.1. [Q6E0U4-7]
DR   RefSeq; NP_001295309.1; NM_001308380.1.
DR   RefSeq; NP_201574.3; NM_033317.4. [Q6E0U4-1]
DR   RefSeq; XP_006723556.1; XM_006723493.2. [Q6E0U4-10]
DR   RefSeq; XP_006723557.1; XM_006723494.2. [Q6E0U4-12]
DR   RefSeq; XP_016882966.1; XM_017027477.1.
DR   PDB; 4F20; X-ray; 2.50 A; Q=251-262.
DR   PDBsum; 4F20; -.
DR   SMR; Q6E0U4; -.
DR   BioGRID; 125000; 16.
DR   IntAct; Q6E0U4; 11.
DR   STRING; 9606.ENSP00000342012; -.
DR   iPTMnet; Q6E0U4; -.
DR   PhosphoSitePlus; Q6E0U4; -.
DR   BioMuta; DMKN; -.
DR   DMDM; 290457677; -.
DR   MassIVE; Q6E0U4; -.
DR   PaxDb; Q6E0U4; -.
DR   PeptideAtlas; Q6E0U4; -.
DR   PRIDE; Q6E0U4; -.
DR   ProteomicsDB; 66258; -. [Q6E0U4-1]
DR   ProteomicsDB; 66259; -. [Q6E0U4-10]
DR   ProteomicsDB; 66260; -. [Q6E0U4-11]
DR   ProteomicsDB; 66261; -. [Q6E0U4-12]
DR   ProteomicsDB; 66262; -. [Q6E0U4-13]
DR   ProteomicsDB; 66263; -. [Q6E0U4-14]
DR   ProteomicsDB; 66264; -. [Q6E0U4-15]
DR   ProteomicsDB; 66265; -. [Q6E0U4-2]
DR   ProteomicsDB; 66266; -. [Q6E0U4-3]
DR   ProteomicsDB; 66267; -. [Q6E0U4-4]
DR   ProteomicsDB; 66268; -. [Q6E0U4-5]
DR   ProteomicsDB; 66269; -. [Q6E0U4-6]
DR   ProteomicsDB; 66270; -. [Q6E0U4-7]
DR   ProteomicsDB; 66271; -. [Q6E0U4-8]
DR   ProteomicsDB; 66272; -. [Q6E0U4-9]
DR   ProteomicsDB; 8509; -.
DR   Antibodypedia; 29370; 107 antibodies.
DR   DNASU; 93099; -.
DR   Ensembl; ENST00000339686; ENSP00000342012; ENSG00000161249. [Q6E0U4-1]
DR   Ensembl; ENST00000408915; ENSP00000386225; ENSG00000161249. [Q6E0U4-15]
DR   Ensembl; ENST00000414866; ENSP00000392222; ENSG00000161249. [Q6E0U4-8]
DR   Ensembl; ENST00000418261; ENSP00000414743; ENSG00000161249. [Q6E0U4-3]
DR   Ensembl; ENST00000419602; ENSP00000391036; ENSG00000161249. [Q6E0U4-16]
DR   Ensembl; ENST00000424570; ENSP00000388404; ENSG00000161249. [Q6E0U4-5]
DR   Ensembl; ENST00000429837; ENSP00000405503; ENSG00000161249. [Q6E0U4-4]
DR   Ensembl; ENST00000447113; ENSP00000394908; ENSG00000161249. [Q6E0U4-6]
DR   Ensembl; ENST00000451297; ENSP00000409513; ENSG00000161249. [Q6E0U4-7]
DR   Ensembl; ENST00000472252; ENSP00000473341; ENSG00000161249. [Q6E0U4-13]
DR   Ensembl; ENST00000492341; ENSP00000474419; ENSG00000161249. [Q6E0U4-13]
DR   GeneID; 93099; -.
DR   KEGG; hsa:93099; -.
DR   UCSC; uc002nzi.5; human. [Q6E0U4-1]
DR   CTD; 93099; -.
DR   DisGeNET; 93099; -.
DR   GeneCards; DMKN; -.
DR   HGNC; HGNC:25063; DMKN.
DR   HPA; ENSG00000161249; Tissue enriched (skin).
DR   neXtProt; NX_Q6E0U4; -.
DR   OpenTargets; ENSG00000161249; -.
DR   PharmGKB; PA145149020; -.
DR   VEuPathDB; HostDB:ENSG00000161249; -.
DR   eggNOG; ENOG502T1EG; Eukaryota.
DR   GeneTree; ENSGT00570000079107; -.
DR   HOGENOM; CLU_045546_1_0_1; -.
DR   InParanoid; Q6E0U4; -.
DR   OMA; WQGMPGS; -.
DR   OrthoDB; 917254at2759; -.
DR   PhylomeDB; Q6E0U4; -.
DR   TreeFam; TF338112; -.
DR   PathwayCommons; Q6E0U4; -.
DR   BioGRID-ORCS; 93099; 25 hits in 1011 CRISPR screens.
DR   ChiTaRS; DMKN; human.
DR   GenomeRNAi; 93099; -.
DR   Pharos; Q6E0U4; Tbio.
DR   PRO; PR:Q6E0U4; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q6E0U4; protein.
DR   Bgee; ENSG00000161249; Expressed in skin of leg and 164 other tissues.
DR   ExpressionAtlas; Q6E0U4; baseline and differential.
DR   Genevisible; Q6E0U4; HS.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:1903575; P:cornified envelope assembly; IBA:GO_Central.
DR   InterPro; IPR033541; Dermokine.
DR   PANTHER; PTHR36881; PTHR36881; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Alternative splicing; Direct protein sequencing;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:15234001"
FT   CHAIN           22..476
FT                   /note="Dermokine"
FT                   /id="PRO_0000330764"
FT   REGION          153..351
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        200..320
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..388
FT                   /note="Missing (in isoform 15)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_033087"
FT   VAR_SEQ         1..353
FT                   /note="Missing (in isoform 13 and isoform 14)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033088"
FT   VAR_SEQ         1..344
FT                   /note="Missing (in isoform 11 and isoform 12)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033089"
FT   VAR_SEQ         1..324
FT                   /note="Missing (in isoform 10)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033090"
FT   VAR_SEQ         1..306
FT                   /note="Missing (in isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033091"
FT   VAR_SEQ         1..287
FT                   /note="Missing (in isoform 8)"
FT                   /evidence="ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033092"
FT   VAR_SEQ         247..346
FT                   /note="GSGSQSGSSGSGSNGDNNNGSSSGGSSSGSSSGGSSGGSSGGSSGNSGGSRG
FT                   DSGSESSWGSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ -> SSTGSSS
FT                   GNHGGSGGGNGHKPGCEKPGNEARGSGESGIQGFRGPGSFPXNMREISKEGNRLLGGSG
FT                   DNYRGQGSSWGSGGGDAVGGVNTV (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033093"
FT   VAR_SEQ         247..307
FT                   /note="Missing (in isoform 4 and isoform 16)"
FT                   /evidence="ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033094"
FT   VAR_SEQ         288..306
FT                   /note="GSSGNSGGSRGDSGSESSW -> MLGITSCSDQQAKEGEGLE (in
FT                   isoform 8)"
FT                   /evidence="ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033095"
FT   VAR_SEQ         307..346
FT                   /note="GSSTGSSSGNHGGSGGGNGHKPGCEKPGNEARGSGESGIQ -> MSPPDQGV
FT                   VESRLWRQMLHKGQGSSWGSGGGDAVGGVNTV (in isoform 9)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033096"
FT   VAR_SEQ         325..346
FT                   /note="GHKPGCEKPGNEARGSGESGIQ -> MRGQGSSWGSGGGDAVGGVNTV (in
FT                   isoform 10)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033097"
FT   VAR_SEQ         330..346
FT                   /note="Missing (in isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033098"
FT   VAR_SEQ         345..346
FT                   /note="IQ -> MR (in isoform 11 and isoform 12)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033099"
FT   VAR_SEQ         346
FT                   /note="Q -> QGFRGQGVSSNMREISKEGNRLLGGSGDNYRGQGSSWGSGGGDAVGG
FT                   VNTV (in isoform 16)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_047249"
FT   VAR_SEQ         346
FT                   /note="Q -> QGQGSSWGSGGGDAVGGVNTV (in isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033100"
FT   VAR_SEQ         346
FT                   /note="Q -> QGFRGQGVSSNMR (in isoform 5)"
FT                   /evidence="ECO:0000303|PubMed:16374476"
FT                   /id="VSP_033101"
FT   VAR_SEQ         347..476
FT                   /note="NSETSPGMFNFDTFWKNFKSKLGFINWDAINKNQVPPPSTRALLYFSRLWED
FT                   FKQNTPFLNWKAIIEGADASSLQKRAGRDDQNYNYNQHAYPTAYGGKYSVKTPAKGGVS
FT                   PSSSASRVQPGLLQWVKFW -> GFRGQGVSSNMREISKEGNRLLGGSGDNYRGQGSSW
FT                   GSGGGDAVGGVNTVNSETSPGMFNFDTFWKNFKSKLGFINWDAINKDQRSSRIP (in
FT                   isoform 6)"
FT                   /evidence="ECO:0000303|PubMed:12975309"
FT                   /id="VSP_033102"
FT   VAR_SEQ         379..386
FT                   /note="NQVPPPST -> DQRSSRIP (in isoform 3, isoform 5 and
FT                   isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:16374476,
FT                   ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033103"
FT   VAR_SEQ         387..476
FT                   /note="Missing (in isoform 3, isoform 5 and isoform 7)"
FT                   /evidence="ECO:0000303|PubMed:16374476,
FT                   ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033104"
FT   VAR_SEQ         389..413
FT                   /note="LLYFSRLWEDFKQNTPFLNWKAIIE -> MNMKPATASALLLLLLGLAWTQG
FT                   SHGW (in isoform 15)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_033105"
FT   VAR_SEQ         429
FT                   /note="Q -> QPGAGWQEVAAVTSK (in isoform 4, isoform 12 and
FT                   isoform 14)"
FT                   /evidence="ECO:0000303|PubMed:15489334,
FT                   ECO:0000303|PubMed:16374476, ECO:0000303|PubMed:17380110"
FT                   /id="VSP_033106"
FT   VARIANT         13
FT                   /note="A -> D (in a colorectal cancer sample; somatic
FT                   mutation)"
FT                   /evidence="ECO:0000269|PubMed:16959974"
FT                   /id="VAR_042720"
FT   VARIANT         69
FT                   /note="E -> D (in dbSNP:rs12460932)"
FT                   /id="VAR_056865"
FT   VARIANT         91
FT                   /note="V -> A (in dbSNP:rs4806163)"
FT                   /evidence="ECO:0000269|PubMed:12975309,
FT                   ECO:0000269|PubMed:15234001, ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:16374476, ECO:0000269|PubMed:17380110"
FT                   /id="VAR_059652"
FT   VARIANT         139
FT                   /note="N -> S (in dbSNP:rs7247001)"
FT                   /evidence="ECO:0000269|PubMed:12975309"
FT                   /id="VAR_056866"
FT   VARIANT         280
FT                   /note="G -> S (in dbSNP:rs11667007)"
FT                   /evidence="ECO:0000269|PubMed:17380110"
FT                   /id="VAR_059653"
FT   VARIANT         415
FT                   /note="A -> S (in dbSNP:rs2293696)"
FT                   /id="VAR_042721"
FT   VARIANT         427
FT                   /note="D -> A (in dbSNP:rs909072)"
FT                   /evidence="ECO:0000269|PubMed:15234001,
FT                   ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16374476,
FT                   ECO:0000269|PubMed:17380110"
FT                   /id="VAR_047337"
FT   CONFLICT        111
FT                   /note="H -> R (in Ref. 3; ABN11271/ABN11272)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="N -> D (in Ref. 3; ABN11273)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        214..215
FT                   /note="QP -> PA (in Ref. 3; ABN11273)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        271
FT                   /note="Missing (in Ref. 3; ABN11273/ABN11274)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        279
FT                   /note="G -> GSSSG (in Ref. 4; AAQ88778)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        378
FT                   /note="K -> M (in Ref. 3; ABN11272)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        419
FT                   /note="S -> L (in Ref. 3; ABN11272)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        450
FT                   /note="T -> S (in Ref. 3; ABN11272)"
FT                   /evidence="ECO:0000305"
FT   STRAND          254..259
FT                   /evidence="ECO:0007829|PDB:4F20"
SQ   SEQUENCE   476 AA;  47082 MW;  C412EC42221BEEC8 CRC64;
     MKFQGPLACL LLALCLGSGE AGPLQSGEES TGTNIGEALG HGLGDALSEG VGKAIGKEAG
     GAAGSKVSEA LGQGTREAVG TGVRQVPGFG VADALGNRVG EAAHALGNTG HEIGRQAEDV
     IRHGADAVRG SWQGVPGHNG AWETSGGHGI FGSQGGLGGQ GQGNPGGLGT PWVHGYPGNS
     AGSFGMNPQG APWGQGGNGG PPNFGTNTQG AVAQPGYGSV RASNQNEGCT NPPPSGSGGG
     SSNSGGGSGS QSGSSGSGSN GDNNNGSSSG GSSSGSSSGG SSGGSSGGSS GNSGGSRGDS
     GSESSWGSST GSSSGNHGGS GGGNGHKPGC EKPGNEARGS GESGIQNSET SPGMFNFDTF
     WKNFKSKLGF INWDAINKNQ VPPPSTRALL YFSRLWEDFK QNTPFLNWKA IIEGADASSL
     QKRAGRDDQN YNYNQHAYPT AYGGKYSVKT PAKGGVSPSS SASRVQPGLL QWVKFW
//