ID ENY2_DANRE Reviewed; 95 AA. AC Q6DH42; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 16-AUG-2004, sequence version 1. DT 18-APR-2012, entry version 59. DE RecName: Full=Enhancer of yellow 2 transcription factor homolog; GN Name=eny2; ORFNames=zgc:92656; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Component of the transcription regulatory histone CC acetylation (HAT) complex SAGA, a multiprotein complex that CC activates transcription by remodeling chromatin and mediating CC histone acetylation and deubiquitination. Within the SAGA complex, CC participates in a subcomplex that specifically deubiquitinates CC both histones H2A and H2B. The SAGA complex is recruited to CC specific gene promoters by activators such as myc, where it is CC required for transcription. Required for nuclear receptor-mediated CC transactivation. May also participate in mRNA export and accurate CC chromatin positioning in the nucleus by tethering genes to the CC nuclear periphery (By similarity). CC -!- SUBUNIT: Component of some SAGA transcription coactivator-HAT CC complexes (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- SIMILARITY: Belongs to the ENY2 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC076140; AAH76140.1; -; mRNA. DR IPI; IPI00488897; -. DR RefSeq; NP_001002427.1; NM_001002427.2. DR UniGene; Dr.76281; -. DR STRING; Q6DH42; -. DR PRIDE; Q6DH42; -. DR Ensembl; ENSDART00000102482; ENSDARP00000093259; ENSDARG00000070046. DR Ensembl; ENSDART00000136215; ENSDARP00000115433; ENSDARG00000070046. DR GeneID; 436700; -. DR KEGG; dre:436700; -. DR CTD; 56943; -. DR ZFIN; ZDB-GENE-040718-124; eny2. DR eggNOG; NOG113530; -. DR GeneTree; ENSGT00390000011748; -. DR HOGENOM; HBG396842; -. DR HOVERGEN; HBG107852; -. DR InParanoid; Q6DH42; -. DR KO; K11368; -. DR OMA; KAHCKDV; -. DR OrthoDB; EOG412M72; -. DR NextBio; 20831143; -. DR ArrayExpress; Q6DH42; -. DR Bgee; Q6DH42; -. DR GO; GO:0000124; C:SAGA complex; ISS:UniProtKB. DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. DR GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. DR InterPro; IPR018783; TF_enhancer_of_yellow_2. DR Pfam; PF10163; EnY2; 1. PE 2: Evidence at transcript level; KW Activator; Chromatin regulator; Complete proteome; mRNA transport; KW Nucleus; Reference proteome; Transcription; Transcription regulation; KW Transport. FT CHAIN 1 95 Enhancer of yellow 2 transcription factor FT homolog. FT /FTId=PRO_0000314132. SQ SEQUENCE 95 AA; 10813 MW; 18B9D63E3C197819 CRC64; MSKESQMRAA INQKLIEMGE RERLKELLRA KLIECGWRDQ LKALCKEVIK EKGIENVTVE DLVAGVTPKG RALVPDSVKK ELLQRIRAFL AQHST //