ID ENY2_DANRE Reviewed; 95 AA. AC Q6DH42; DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot. DT 16-AUG-2004, sequence version 1. DT 29-MAY-2024, entry version 115. DE RecName: Full=Transcription and mRNA export factor ENY2 {ECO:0000255|HAMAP-Rule:MF_03046}; DE AltName: Full=Enhancer of yellow 2 transcription factor homolog {ECO:0000255|HAMAP-Rule:MF_03046}; GN Name=eny2; ORFNames=zgc:92656; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Involved in mRNA export coupled transcription activation by CC association with both the TREX-2 and the SAGA complexes. The CC transcription regulatory histone acetylation (HAT) complex SAGA is a CC multiprotein complex that activates transcription by remodeling CC chromatin and mediating histone acetylation and deubiquitination. CC Within the SAGA complex, participates in a subcomplex that specifically CC deubiquitinates histones. The SAGA complex is recruited to specific CC gene promoters by activators, where it is required for transcription. CC The TREX-2 complex functions in docking export-competent CC ribonucleoprotein particles (mRNPs) to the nuclear entrance of the CC nuclear pore complex (nuclear basket). TREX-2 participates in mRNA CC export and accurate chromatin positioning in the nucleus by tethering CC genes to the nuclear periphery (By similarity). {ECO:0000250}. CC -!- SUBUNIT: Component of the nuclear pore complex (NPC)-associated TREX-2 CC complex (transcription and export complex 2). Component of the SAGA CC transcription coactivator-HAT complex. Within the SAGA complex, CC participates in a subcomplex of SAGA called the DUB module CC (deubiquitination module) (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000255|HAMAP- CC Rule:MF_03046}. CC -!- SIMILARITY: Belongs to the ENY2 family. {ECO:0000255|HAMAP- CC Rule:MF_03046}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC076140; AAH76140.1; -; mRNA. DR RefSeq; NP_001002427.1; NM_001002427.2. DR AlphaFoldDB; Q6DH42; -. DR SMR; Q6DH42; -. DR STRING; 7955.ENSDARP00000093259; -. DR PaxDb; 7955-ENSDARP00000115433; -. DR GeneID; 436700; -. DR KEGG; dre:436700; -. DR AGR; ZFIN:ZDB-GENE-040718-124; -. DR CTD; 56943; -. DR ZFIN; ZDB-GENE-040718-124; eny2. DR eggNOG; KOG4479; Eukaryota. DR HOGENOM; CLU_134052_1_1_1; -. DR InParanoid; Q6DH42; -. DR OMA; RLMCRNI; -. DR OrthoDB; 5487980at2759; -. DR PhylomeDB; Q6DH42; -. DR TreeFam; TF326556; -. DR PRO; PR:Q6DH42; -. DR Proteomes; UP000000437; Chromosome 16. DR Bgee; ENSDARG00000070046; Expressed in mature ovarian follicle and 28 other cell types or tissues. DR GO; GO:0071819; C:DUBm complex; IBA:GO_Central. DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-UniRule. DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0000124; C:SAGA complex; ISS:UniProtKB. DR GO; GO:0070390; C:transcription export complex 2; IEA:UniProtKB-UniRule. DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central. DR GO; GO:0003713; F:transcription coactivator activity; ISS:UniProtKB. DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW. DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IBA:GO_Central. DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; ISS:UniProtKB. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:UniProtKB-UniRule. DR Gene3D; 1.10.246.140; -; 1. DR HAMAP; MF_03046; ENY2_Sus1; 1. DR InterPro; IPR018783; TF_ENY2. DR InterPro; IPR038212; TF_EnY2_sf. DR PANTHER; PTHR12514; ENHANCER OF YELLOW 2 TRANSCRIPTION FACTOR; 1. DR PANTHER; PTHR12514:SF1; TRANSCRIPTION AND MRNA EXPORT FACTOR ENY2; 1. DR Pfam; PF10163; EnY2; 1. PE 3: Inferred from homology; KW Activator; Chromatin regulator; mRNA transport; Nucleus; Protein transport; KW Reference proteome; Transcription; Transcription regulation; Translocation; KW Transport. FT CHAIN 1..95 FT /note="Transcription and mRNA export factor ENY2" FT /id="PRO_0000314132" SQ SEQUENCE 95 AA; 10813 MW; 18B9D63E3C197819 CRC64; MSKESQMRAA INQKLIEMGE RERLKELLRA KLIECGWRDQ LKALCKEVIK EKGIENVTVE DLVAGVTPKG RALVPDSVKK ELLQRIRAFL AQHST //