ID Q6DEG0_DANRE Unreviewed; 573 AA. AC Q6DEG0; DT 16-AUG-2004, integrated into UniProtKB/TrEMBL. DT 16-AUG-2004, sequence version 1. DT 03-AUG-2022, entry version 160. DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614}; DE EC=2.3.2.27 {ECO:0000256|PIRNR:PIRNR015614}; GN OrderedLocusNames=traf3 {ECO:0000313|EMBL:AAH77157.1, GN ECO:0000313|Ensembl:ENSDARP00000038596, GN ECO:0000313|ZFIN:ZDB-GENE-040801-257}; GN ORFNames=SO:0001217 {ECO:0000313|ZFIN:ZDB-GENE-040801-257}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH77157.1}; RN [1] {ECO:0000313|EMBL:AAH77157.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole {ECO:0000313|EMBL:AAH77157.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000038596} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000038596}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000038596} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000038596}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). CC -!- CATALYTIC ACTIVITY: CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L- CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.; CC EC=2.3.2.27; Evidence={ECO:0000256|PIRNR:PIRNR015614}; CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496, CC ECO:0000256|PIRNR:PIRNR015614}. CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family. CC {ECO:0000256|PIRNR:PIRNR015614}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX511189; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR392327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC077157; AAH77157.1; -; mRNA. DR RefSeq; NP_001003513.1; NM_001003513.1. DR STRING; 7955.ENSDARP00000105765; -. DR Ensembl; ENSDART00000031458.8; ENSDARP00000038596.7; ENSDARG00000022000.10. DR GeneID; 445119; -. DR KEGG; dre:445119; -. DR CTD; 7187; -. DR ZFIN; ZDB-GENE-040801-257; SO:0001217. DR ZFIN; ZDB-GENE-040801-257; traf3. DR eggNOG; KOG0297; Eukaryota. DR GeneTree; ENSGT00940000163836; -. DR HOGENOM; CLU_021061_4_1_1; -. DR OMA; ETVCPSF; -. DR OrthoDB; 918518at2759; -. DR TreeFam; TF321154; -. DR Reactome; R-DRE-5668541; TNFR2 non-canonical NF-kB pathway. DR Reactome; R-DRE-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway. DR Reactome; R-DRE-5689896; Ovarian tumor domain proteases. DR Proteomes; UP000814640; Chromosome 17. DR Bgee; ENSDARG00000022000; Expressed in spleen and 20 other tissues. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IBA:GO_Central. DR GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IBA:GO_Central. DR GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central. DR GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR GO; GO:0001817; P:regulation of cytokine production; IEA:InterPro. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:InterPro. DR GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central. DR GO; GO:0001878; P:response to yeast; IDA:ZFIN. DR GO; GO:0008063; P:Toll signaling pathway; IEA:InterPro. DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central. DR CDD; cd03777; MATH_TRAF3; 1. DR Gene3D; 2.60.210.10; -; 1. DR Gene3D; 3.30.40.10; -; 3. DR InterPro; IPR002083; MATH/TRAF_dom. DR InterPro; IPR043211; TNF_rcpt-assoc_TRAF. DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met. DR InterPro; IPR008974; TRAF-like. DR InterPro; IPR027128; TRAF3. DR InterPro; IPR037304; TRAF3_MATH. DR InterPro; IPR018957; Znf_C3HC4_RING-type. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR InterPro; IPR001293; Znf_TRAF. DR PANTHER; PTHR10131; PTHR10131; 1. DR PANTHER; PTHR10131:SF76; PTHR10131:SF76; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR Pfam; PF02176; zf-TRAF; 1. DR PIRSF; PIRSF015614; TRAF; 1. DR SMART; SM00061; MATH; 1. DR SMART; SM00184; RING; 1. DR PROSITE; PS50144; MATH; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. DR PROSITE; PS50145; ZF_TRAF; 2. PE 2: Evidence at transcript level; KW Apoptosis {ECO:0000256|ARBA:ARBA00022703}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR015614}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRNR:PIRNR015614}; Receptor {ECO:0000313|EMBL:AAH77157.1}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PIRNR:PIRNR015614}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00207}. FT DOMAIN 56..94 FT /note="RING-type" FT /evidence="ECO:0000259|PROSITE:PS50089" FT DOMAIN 139..192 FT /note="TRAF-type" FT /evidence="ECO:0000259|PROSITE:PS50145" FT DOMAIN 194..251 FT /note="TRAF-type" FT /evidence="ECO:0000259|PROSITE:PS50145" FT DOMAIN 420..565 FT /note="MATH" FT /evidence="ECO:0000259|PROSITE:PS50144" FT ZN_FING 139..192 FT /note="TRAF-type" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207" FT ZN_FING 194..251 FT /note="TRAF-type" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207" FT REGION 1..34 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 290..324 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 1..21 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 573 AA; 65608 MW; F7C441E6725833C2 CRC64; MSAGRNVEQQ IPLQQRPPSL AMPSMAQRPR PEPGFSPLHG GFRDHFVTTP EPKYCCETCR LVLCNPRQTE CGHRFCESCI NELLSKPNPV CPADLLPLFE DKIFRDVCCN REIMALKVYC RSEKNGCKEQ MCLQQVMEHL VICPYFEVPC PLGKCKEKMM RKDMPEHLSR KCKHREVTCE FCSLKMALTE LQKHKETVCP AFPVACPNHC SFSSILRSEL SSHQHDCPKA QVTCSFIRYG CSYKGLNQEM REHESSFASE HLRMMAVRNT TLEAKVEDVK SELMERYKVL PSLSSRLAEV ERQYEEMREK NRQLEQKLVS MQMLMSSHSE KLLEVEMELR ELRPLRAMRE EVETLRGSVE SMRSMVSSLD SSCVNSASGS HTLASLEQQL TRHDDLMSVH DVRLAEMDLK LQVLETASFN GTLIWKIRDY KRRKQEAVVS KTLSLYSQPF YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF VVMRGEYDAL LQWPFKQKVT LMLMDQGPAR KHLGDAFKPD PSSSSFRRPT GEMNIASGCP LFVAQTVLEN GTYIKDDTIF IKVTVDTSDL PDP //