ID Q6DEG0_DANRE Unreviewed; 573 AA. AC Q6DEG0; DT 16-AUG-2004, integrated into UniProtKB/TrEMBL. DT 16-AUG-2004, sequence version 1. DT 28-MAR-2018, entry version 130. DE SubName: Full=TNF receptor-associated factor 3 {ECO:0000313|EMBL:AAH77157.1, ECO:0000313|Ensembl:ENSDARP00000038596}; GN Name=traf3 {ECO:0000313|EMBL:AAH77157.1, GN ECO:0000313|Ensembl:ENSDARP00000038596, GN ECO:0000313|ZFIN:ZDB-GENE-040801-257}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH77157.1}; RN [1] {ECO:0000313|EMBL:AAH77157.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Whole {ECO:0000313|EMBL:AAH77157.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSDARP00000038596} RP IDENTIFICATION. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000038596}; RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSDARP00000038596, ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000038596, RC ECO:0000313|Proteomes:UP000000437}; RX PubMed=23594743; DOI=10.1038/nature12111; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., RA Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., RA McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., RA Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T., RA Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., RA Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., RA Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., RA Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., RA Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., RA Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., RA Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., RA Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., RA Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., RA Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., RA Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., RA Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., RA Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., RA Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., RA Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., RA Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., RA Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., RA Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., RA Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., RA Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., RA Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., RA Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the RT human genome."; RL Nature 496:498-503(2013). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX511189; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CR392327; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC077157; AAH77157.1; -; mRNA. DR RefSeq; NP_001003513.1; NM_001003513.1. DR UniGene; Dr.81587; -. DR STRING; 7955.ENSDARP00000038596; -. DR Ensembl; ENSDART00000031458; ENSDARP00000038596; ENSDARG00000022000. DR GeneID; 445119; -. DR KEGG; dre:445119; -. DR CTD; 7187; -. DR ZFIN; ZDB-GENE-040801-257; traf3. DR eggNOG; ENOG410ISDV; Eukaryota. DR eggNOG; ENOG410YQ97; LUCA. DR GeneTree; ENSGT00550000074359; -. DR HOGENOM; HOG000231557; -. DR HOVERGEN; HBG058222; -. DR KO; K03174; -. DR OMA; FCETCMA; -. DR OrthoDB; EOG091G0GHD; -. DR TreeFam; TF321154; -. DR Reactome; R-DRE-5668541; TNFR2 non-canonical NF-kB pathway. DR Reactome; R-DRE-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway. DR Reactome; R-DRE-5689896; Ovarian tumor domain proteases. DR Reactome; R-DRE-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon. DR Proteomes; UP000000437; Chromosome 17. DR Bgee; ENSDARG00000022000; -. DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0045087; P:innate immune response; IEA:InterPro. DR GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IEA:InterPro. DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro. DR GO; GO:0001817; P:regulation of cytokine production; IEA:InterPro. DR GO; GO:0050688; P:regulation of defense response to virus; IEA:InterPro. DR GO; GO:0001878; P:response to yeast; IDA:ZFIN. DR GO; GO:0008063; P:Toll signaling pathway; IEA:InterPro. DR GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro. DR CDD; cd03777; MATH_TRAF3; 1. DR Gene3D; 2.60.210.10; -; 1. DR Gene3D; 3.30.40.10; -; 3. DR InterPro; IPR002083; MATH/TRAF_dom. DR InterPro; IPR012227; TNF_rcpt--assoc_TRAF. DR InterPro; IPR008974; TRAF-like. DR InterPro; IPR027128; TRAF3. DR InterPro; IPR037304; TRAF3_MATH. DR InterPro; IPR018957; Znf_C3HC4_RING-type. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR017907; Znf_RING_CS. DR InterPro; IPR001293; Znf_TRAF. DR PANTHER; PTHR10131:SF76; PTHR10131:SF76; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR Pfam; PF02176; zf-TRAF; 1. DR PIRSF; PIRSF015614; TRAF; 1. DR SMART; SM00061; MATH; 1. DR SMART; SM00184; RING; 1. DR SUPFAM; SSF49599; SSF49599; 3. DR PROSITE; PS50144; MATH; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. DR PROSITE; PS50145; ZF_TRAF; 2. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000000437}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00207, KW ECO:0000256|SAAS:SAAS00988653}; KW Receptor {ECO:0000313|EMBL:AAH77157.1}; KW Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00207, KW ECO:0000256|SAAS:SAAS00988516}; KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00207, KW ECO:0000256|SAAS:SAAS00988536}. FT DOMAIN 56 94 RING-type. {ECO:0000259|PROSITE:PS50089}. FT DOMAIN 139 192 TRAF-type. {ECO:0000259|PROSITE:PS50145}. FT DOMAIN 194 251 TRAF-type. {ECO:0000259|PROSITE:PS50145}. FT DOMAIN 420 565 MATH. {ECO:0000259|PROSITE:PS50144}. FT ZN_FING 139 192 TRAF-type. {ECO:0000256|PROSITE-ProRule: FT PRU00207}. FT ZN_FING 194 251 TRAF-type. {ECO:0000256|PROSITE-ProRule: FT PRU00207}. FT COILED 290 324 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 573 AA; 65608 MW; F7C441E6725833C2 CRC64; MSAGRNVEQQ IPLQQRPPSL AMPSMAQRPR PEPGFSPLHG GFRDHFVTTP EPKYCCETCR LVLCNPRQTE CGHRFCESCI NELLSKPNPV CPADLLPLFE DKIFRDVCCN REIMALKVYC RSEKNGCKEQ MCLQQVMEHL VICPYFEVPC PLGKCKEKMM RKDMPEHLSR KCKHREVTCE FCSLKMALTE LQKHKETVCP AFPVACPNHC SFSSILRSEL SSHQHDCPKA QVTCSFIRYG CSYKGLNQEM REHESSFASE HLRMMAVRNT TLEAKVEDVK SELMERYKVL PSLSSRLAEV ERQYEEMREK NRQLEQKLVS MQMLMSSHSE KLLEVEMELR ELRPLRAMRE EVETLRGSVE SMRSMVSSLD SSCVNSASGS HTLASLEQQL TRHDDLMSVH DVRLAEMDLK LQVLETASFN GTLIWKIRDY KRRKQEAVVS KTLSLYSQPF YTGYFGYKMC ARVYLNGDGM GKGTHLSLFF VVMRGEYDAL LQWPFKQKVT LMLMDQGPAR KHLGDAFKPD PSSSSFRRPT GEMNIASGCP LFVAQTVLEN GTYIKDDTIF IKVTVDTSDL PDP //