ID   NOP12_YARLI             Reviewed;         509 AA.
AC   Q6C2Q7;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   22-FEB-2023, entry version 95.
DE   RecName: Full=Nucleolar protein 12;
GN   Name=NOP12; OrderedLocusNames=YALI0F05918g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in pre-25S rRNA processing. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRM RBM34 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG77862.1; -; Genomic_DNA.
DR   RefSeq; XP_505055.1; XM_505055.1.
DR   AlphaFoldDB; Q6C2Q7; -.
DR   SMR; Q6C2Q7; -.
DR   STRING; 4952.CAG77862; -.
DR   EnsemblFungi; CAG77862; CAG77862; YALI0_F05918g.
DR   GeneID; 2908470; -.
DR   KEGG; yli:YALI0F05918g; -.
DR   VEuPathDB; FungiDB:YALI0_F05918g; -.
DR   HOGENOM; CLU_006468_0_0_1; -.
DR   InParanoid; Q6C2Q7; -.
DR   OMA; QFHDENA; -.
DR   OrthoDB; 36980at2759; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12669; RRM1_Nop12p_like; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR034777; Nop12_RRM1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR23236; EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H; 1.
DR   PANTHER; PTHR23236:SF25; RNA-BINDING PROTEIN 34; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   3: Inferred from homology;
KW   Coiled coil; Nucleus; Reference proteome; Repeat; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..509
FT                   /note="Nucleolar protein 12"
FT                   /id="PRO_0000081674"
FT   DOMAIN          168..266
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          274..359
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          345..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          419..509
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          33..114
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..23
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..84
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..133
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..393
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        475..502
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   509 AA;  57053 MW;  BBF37FDB0FB732E9 CRC64;
     MTTTKDNSGL AALFANSSGP RQKPQRAGKV DPVRDQQEDK MEVEDEEEDE EEDEEDEEED
     EEDEEDEEEK EEDDDDDDDE EEIEEPVIKK SKKNKKSKEE SADLEDQYMA KLAEEVAEEK
     PMVAETSAEE IKVDEPESDS EDEPELDVDE ETKKKLEATN KELDKADYTI FVGNVSSEVI
     TDKTVYNNFK ALFAAIGTVA SVRFRSISFS KLLPRKVAFI SQQFHSKRDT VNAYIVFKNV
     KSVKGALTLN GSVFKGFHMR VDSVAHPGAQ DHKRCVFVGA LDFEEQEESL WEAFSSCGDV
     EYVRIVRDPK TNVGKGFAYV QFKDVNSVEQ ALLLNGKGIN ELSKSTTNKR KLRVSRAKSQ
     HSQERAKQAD MKNIRNAKTE GLSRDEKSHF GRAQSRLGKA GKAQLQSIVQ EGLRAKKEDG
     KVNLARSKRR GVKPNKNRVE KPGQSRAEKR KAMFGTPTNG APGAGGKKKR LTTRSQKFKQ
     DGGVKKDGDA KKDGPKKERD GSKKGSKKN
//