ID Q6BDC3_BRARE PRELIMINARY; PRT; 332 AA. AC Q6BDC3; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 04-APR-2006, entry version 16. DE Lhx7. GN Name=lhx8; Synonyms=lhx7; OS Brachydanio rerio (Zebrafish) (Danio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955; RN [1] RP NUCLEOTIDE SEQUENCE. RC TISSUE=Whole larvae; RX PubMed=15355794; DOI=10.1016/j.ydbio.2004.07.003; RA Jackman W.R., Draper B.W., Stock D.W.; RT "Fgf signaling is required for zebrafish tooth development."; RL Dev. Biol. 274:139-157(2004). CC -!- FUNCTION: Sequence-specific transcription factor which is part of CC a developmental regulatory system that provides cells with CC specific positional identities on the anterior-posterior axis (By CC similarity). CC -!- SUBCELLULAR LOCATION: Nucleus (By similarity). CC -!- SIMILARITY: Contains 2 LIM zinc-binding domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY664404; AAT90496.1; -; mRNA. DR UniGene; Dr.25698; -. DR Ensembl; ENSDARG00000002330; Danio rerio. DR ZFIN; ZDB-GENE-031008-2; lhx8. DR GO; GO:0005634; C:nucleus; IEA. DR GO; GO:0046872; F:metal ion binding; IEA. DR GO; GO:0003700; F:transcription factor activity; IEA. DR GO; GO:0008270; F:zinc ion binding; IEA. DR GO; GO:0007275; P:development; IEA. DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA. DR InterPro; IPR001356; Homeobox. DR InterPro; IPR012287; Homeodomain-rel. DR InterPro; IPR002197; HTH_Fis. DR InterPro; IPR007107; LIM_homeo. DR InterPro; IPR001781; LIM_Zn_bd. DR InterPro; IPR002016; Peroxidase. DR Pfam; PF00046; Homeobox; 1. DR Pfam; PF00412; LIM; 2. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR01590; HTHFIS. DR ProDom; PD000010; Homeobox; 1. DR ProDom; PD000094; LIM; 2. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 2. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 2. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. DR PROSITE; PS00435; PEROXIDASE_1; UNKNOWN_1. KW DNA-binding; Developmental protein; Homeobox; LIM domain; KW Metal-binding; Nuclear protein; Transcription; KW Transcription regulation; Zinc. SQ SEQUENCE 332 AA; 37388 MW; 9EEAA58759E7C962 CRC64; MYWKNEQTTS KESPSKNTAK TQDLFEEVSC SSSLSLSPSS SPHTMTEKAI CTSCGTEIVD KYLLKVNDMC WHVRCLSCSV CQTSLGRHIS CYIKEKEIFC KLDYFRKYGT RCAHCGRNIH SNDWVRRAKG NTYHLACFAC FSCKRQLSTG EEFALVDERV LCRVHYDCML DNLKRAMENG KGVNVEGAVP SEQEVNQPKP AKRARTSFTA DQLQVMQAQF AQDNNPDAQT LQKLAERTGL SRRVIQVWFQ NCRARHKKHV SPNHSSAAPV SSLQSAHLSP PLIDELQYTA FAPVDTPMLT ALHSYMDVHS PTSLVLQPLL PHSMTQLPIS HA //