ID Q6BDC3_DANRE Unreviewed; 332 AA. AC Q6BDC3; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 24-JAN-2024, entry version 145. DE SubName: Full=LIM homeobox 8 {ECO:0000313|EMBL:AAI17602.1}; DE SubName: Full=LIM/homeobox protein Lhx8 {ECO:0000313|RefSeq:NP_001003980.1}; DE SubName: Full=Lhx7 {ECO:0000313|EMBL:AAT90496.1}; GN Name=lhx7 {ECO:0000313|EMBL:AAT90496.1, GN ECO:0000313|RefSeq:NP_001003980.1}; GN Synonyms=cb875 {ECO:0000313|RefSeq:NP_001003980.1}, fk78g12 GN {ECO:0000313|RefSeq:NP_001003980.1}, lhx8 GN {ECO:0000313|EMBL:AAI17602.1, ECO:0000313|RefSeq:NP_001003980.1, GN ECO:0000313|ZFIN:ZDB-GENE-031008-2}, wu:fk78g12 GN {ECO:0000313|RefSeq:NP_001003980.1}; GN OrderedLocusNames=lhx8a {ECO:0000313|RefSeq:NP_001003980.1, GN ECO:0000313|ZFIN:ZDB-GENE-031008-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Danionidae; Danioninae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAT90496.1}; RN [1] {ECO:0000313|EMBL:AAT90496.1, ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Whole larvae {ECO:0000313|EMBL:AAT90496.1}; RX PubMed=15355794; DOI=10.1016/j.ydbio.2004.07.003; RA Jackman W.R., Draper B.W., Stock D.W.; RT "Fgf signaling is required for zebrafish tooth development."; RL Dev. Biol. 274:139-157(2004). RN [2] {ECO:0000313|EMBL:AAI17602.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis {ECO:0000313|EMBL:AAI17602.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=18181142; RA Mueller T., Wullimann M.F., Guo S.; RT "Early teleostean basal ganglia development visualized by zebrafish Dlx2a, RT Lhx6, Lhx7, Tbr2 (eomesa), and GAD67 gene expression."; RL J. Comp. Neurol. 507:1245-1257(2008). RN [4] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19646228; RA Webb K.J., Norton W.H., Trumbach D., Meijer A.H., Ninkovic J., Topp S., RA Heck D., Marr C., Wurst W., Theis F.J., Spaink H.P., Bally-Cuif L.; RT "Zebrafish reward mutants reveal novel transcripts mediating the behavioral RT effects of amphetamine."; RL Genome Biol. 10:R81-R81(2009). RN [5] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=19439512; RA Kassahn K.S., Dang V.T., Wilkins S.J., Perkins A.C., Ragan M.A.; RT "Evolution of gene function and regulatory control after whole-genome RT duplication: comparative analyses in vertebrates."; RL Genome Res. 19:1404-1418(2009). RN [6] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=21118524; RA Jackman W.R., Yoo J.J., Stock D.W.; RT "Hedgehog signaling is required at multiple stages of zebrafish tooth RT development."; RL BMC Dev. Biol. 10:119-119(2010). RN [7] {ECO:0000313|Proteomes:UP000000437} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=23594743; DOI=10.1038/nature12111; RG Genome Reference Consortium Zebrafish; RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J., RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D., RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B., RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D., RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., RA Rogers J., Stemple D.L.; RT "The zebrafish reference genome sequence and its relationship to the human RT genome."; RL Nature 496:498-503(2013). RN [8] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26699284; RA Tallafuss A., Kelly M., Gay L., Gibson D., Batzel P., Karfilis K.V., RA Eisen J., Stankunas K., Postlethwait J.H., Washbourne P.; RT "Transcriptomes of post-mitotic neurons identify the usage of alternative RT pathways during adult and embryonic neuronal differentiation."; RL BMC Genomics 16:1100-1100(2015). RN [9] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27189481; RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I., RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y., RA Bobe J.; RT "Gene evolution and gene expression after whole genome duplication in fish: RT the PhyloFish database."; RL BMC Genomics 17:368-368(2016). RN [10] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=27260860; RA Hulsey C.D., Fraser G.J., Meyer A.; RT "Biting into the Genome to Phenome Map: Developmental Genetic Modularity of RT Cichlid Fish Dentitions."; RL Integr. Comp. Biol. 56:373-388(2016). RN [11] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28738802; RA Lee S.L.J., Horsfield J.A., Black M.A., Rutherford K., Fisher A., RA Gemmell N.J.; RT "Histological and transcriptomic effects of 17alpha-methyltestosterone on RT zebrafish gonad development."; RL BMC Genomics 18:557-557(2017). RN [12] {ECO:0000313|RefSeq:NP_001003980.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28756106; RA Nakayama Y., Inomata C., Yuikawa T., Tsuda S., Yamasu K.; RT "Comprehensive analysis of target genes in zebrafish embryos reveals gbx2 RT involvement in neurogenesis."; RL Dev. Biol. 430:237-248(2017). RN [13] {ECO:0000313|RefSeq:NP_001003980.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (SEP-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, CC ECO:0000256|RuleBase:RU000682}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC117601; AAI17602.1; -; mRNA. DR EMBL; AY664404; AAT90496.1; -; mRNA. DR RefSeq; NP_001003980.1; NM_001003980.2. DR GeneID; 378959; -. DR KEGG; dre:378959; -. DR CTD; 378959; -. DR ZFIN; ZDB-GENE-031008-2; lhx8a. DR OrthoDB; 2880952at2759; -. DR Proteomes; UP000000437; Chromosome 2. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:ZFIN. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0021884; P:forebrain neuron development; IBA:GO_Central. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd00086; homeodomain; 1. DR CDD; cd09381; LIM1_Lhx7_Lhx8; 1. DR CDD; cd09383; LIM2_Lhx7_Lhx8; 1. DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR001781; Znf_LIM. DR PANTHER; PTHR24208; LIM/HOMEOBOX PROTEIN LHX; 1. DR PANTHER; PTHR24208:SF117; LIM/HOMEOBOX PROTEIN LHX8; 1. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 1. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE- KW ProRule:PRU00108}; KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE- KW ProRule:PRU00125}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE- KW ProRule:PRU00125}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000000437}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}. FT DOMAIN 49..109 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 110..172 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 199..259 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 201..260 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" SQ SEQUENCE 332 AA; 37388 MW; 9EEAA58759E7C962 CRC64; MYWKNEQTTS KESPSKNTAK TQDLFEEVSC SSSLSLSPSS SPHTMTEKAI CTSCGTEIVD KYLLKVNDMC WHVRCLSCSV CQTSLGRHIS CYIKEKEIFC KLDYFRKYGT RCAHCGRNIH SNDWVRRAKG NTYHLACFAC FSCKRQLSTG EEFALVDERV LCRVHYDCML DNLKRAMENG KGVNVEGAVP SEQEVNQPKP AKRARTSFTA DQLQVMQAQF AQDNNPDAQT LQKLAERTGL SRRVIQVWFQ NCRARHKKHV SPNHSSAAPV SSLQSAHLSP PLIDELQYTA FAPVDTPMLT ALHSYMDVHS PTSLVLQPLL PHSMTQLPIS HA //