ID Q6BDC3_DANRE Unreviewed; 332 AA. AC Q6BDC3; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 11-DEC-2019, entry version 130. DE SubName: Full=LIM homeobox 8 {ECO:0000313|EMBL:AAI17602.1}; DE SubName: Full=Lhx7 {ECO:0000313|EMBL:AAT90496.1}; GN Name=lhx8a {ECO:0000313|ZFIN:ZDB-GENE-031008-2}; GN Synonyms=lhx7 {ECO:0000313|EMBL:AAT90496.1}, lhx8 GN {ECO:0000313|EMBL:AAI17602.1, ECO:0000313|ZFIN:ZDB-GENE-031008-2}; OS Danio rerio (Zebrafish) (Brachydanio rerio). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; OC Cyprinidae; Danio. OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAT90496.1}; RN [1] {ECO:0000313|EMBL:AAT90496.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Whole larvae {ECO:0000313|EMBL:AAT90496.1}; RX PubMed=15355794; DOI=10.1016/j.ydbio.2004.07.003; RA Jackman W.R., Draper B.W., Stock D.W.; RT "Fgf signaling is required for zebrafish tooth development."; RL Dev. Biol. 274:139-157(2004). RN [2] {ECO:0000313|EMBL:AAI17602.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Testis {ECO:0000313|EMBL:AAI17602.1}; RG NIH - Zebrafish Gene Collection (ZGC) project; RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, CC ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00866652}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC117601; AAI17602.1; -; mRNA. DR EMBL; AY664404; AAT90496.1; -; mRNA. DR RefSeq; NP_001003980.1; NM_001003980.2. DR GeneID; 378959; -. DR KEGG; dre:378959; -. DR CTD; 378959; -. DR ZFIN; ZDB-GENE-031008-2; lhx8a. DR eggNOG; KOG0490; Eukaryota. DR eggNOG; ENOG410YIJ3; LUCA. DR KO; K09375; -. DR OrthoDB; 1161127at2759; -. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:ZFIN. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0021884; P:forebrain neuron development; IBA:GO_Central. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd00086; homeodomain; 1. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR001781; Znf_LIM. DR Pfam; PF00046; Homeodomain; 1. DR Pfam; PF00412; LIM; 2. DR SMART; SM00389; HOX; 1. DR SMART; SM00132; LIM; 2. DR SUPFAM; SSF46689; SSF46689; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. DR PROSITE; PS00478; LIM_DOMAIN_1; 1. DR PROSITE; PS50023; LIM_DOMAIN_2; 2. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00866408, KW ECO:0000313|EMBL:AAI17602.1}; KW Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00866449, KW ECO:0000313|EMBL:AAI17602.1}; KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125, KW ECO:0000256|SAAS:SAAS00113461}; KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125, KW ECO:0000256|SAAS:SAAS00113326}; KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108, KW ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00866413}; KW Repeat {ECO:0000256|SAAS:SAAS01094919}; KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125, ECO:0000256|SAAS:SAAS00474801}. FT DOMAIN 49..109 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 110..172 FT /note="LIM zinc-binding" FT /evidence="ECO:0000259|PROSITE:PS50023" FT DOMAIN 199..259 FT /note="Homeobox" FT /evidence="ECO:0000259|PROSITE:PS50071" FT DNA_BIND 201..260 FT /note="Homeobox" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108" SQ SEQUENCE 332 AA; 37388 MW; 9EEAA58759E7C962 CRC64; MYWKNEQTTS KESPSKNTAK TQDLFEEVSC SSSLSLSPSS SPHTMTEKAI CTSCGTEIVD KYLLKVNDMC WHVRCLSCSV CQTSLGRHIS CYIKEKEIFC KLDYFRKYGT RCAHCGRNIH SNDWVRRAKG NTYHLACFAC FSCKRQLSTG EEFALVDERV LCRVHYDCML DNLKRAMENG KGVNVEGAVP SEQEVNQPKP AKRARTSFTA DQLQVMQAQF AQDNNPDAQT LQKLAERTGL SRRVIQVWFQ NCRARHKKHV SPNHSSAAPV SSLQSAHLSP PLIDELQYTA FAPVDTPMLT ALHSYMDVHS PTSLVLQPLL PHSMTQLPIS HA //