ID Q6BCY4_HUMAN PRELIMINARY; PRT; 276 AA. AC Q6BCY4; DT 25-OCT-2004 (TrEMBLrel. 28, Created) DT 25-OCT-2004 (TrEMBLrel. 28, Last sequence update) DT 25-OCT-2004 (TrEMBLrel. 28, Last annotation update) DE Cytochrome b5 reductase b5R.2. GN Name=CYB5R2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RA Baker M.A., Krutskikh A., Curry B.J., Hetherington L., Aitken R.J.; RT "Identification of cytochrome b5 reductase b5R.2 (CYB5R2), as the RT enzyme responsible for NADH-dependent lucigenin chemiluminescence."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Desaturation and elongation of fatty acids, cholesterol CC biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin CC reduction (By similarity). CC -!- CATALYTIC ACTIVITY: NADH + 2 ferricytochrome b5 = NAD(+) + 2 CC ferrocytochrome b5. CC -!- COFACTOR: FAD (By similarity). CC -!- PATHWAY: Microsomal electron transport system. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY665398; AAT75296.1; -. DR GO; GO:0016491; F:oxidoreductase activity; IEA. DR GO; GO:0006118; P:electron transport; IEA. DR InterPro; IPR001834; Cyt_B5_reductase. DR InterPro; IPR008333; FAD_binding_6. DR InterPro; IPR001709; FPN_cyt_redctse. DR InterPro; IPR001433; Oxred_FAD/NAD(P). DR Pfam; PF00970; FAD_binding_6; 1. DR Pfam; PF00175; NAD_binding_1; 1. DR PRINTS; PR00406; CYTB5RDTASE. DR PRINTS; PR00371; FPNCR. KW Cholesterol biosynthesis; Endoplasmic reticulum; FAD; Flavoprotein; KW Lipid synthesis; Membrane; NAD; Oxidoreductase; Steroid biosynthesis; KW Sterol biosynthesis. SQ SEQUENCE 276 AA; 31458 MW; A475039D1E56ABDA CRC64; MNSRRREPIT LQDPEAKYPL PLIEKEKISH NTRRFRFGLP SPDHVLGLPV GNYVQLLAKI DNELVVRAYT PVSSDDDRGF VDLIIKIYFK NVHPQYPEGG KMTQYLENMK IGETIFFRGP RGRLFYHGPG NLGIRPDQTS EPKKTLADHL GMIAGGTGIT PMLQLIRHIT KDPSDRTRMS LIFANQTEED ILVRKELEEI ARTHPDQFNL WYTLDRPPIG WKYSSGFVTA DMIKEHLPPP AKSTLILVCG PPPLIQTAAH PNLEKLGYTQ DMIFTY //