ID Q6AXD8_MOUSE Unreviewed; 326 AA. AC Q6AXD8; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 13-SEP-2023, entry version 97. DE RecName: Full=Adenosine receptor A1 {ECO:0000256|ARBA:ARBA00021736, ECO:0000256|RuleBase:RU201114}; GN Name=Adora1 {ECO:0000313|EMBL:AAH79624.1, ECO:0000313|MGI:MGI:99401}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH79624.1}; RN [1] {ECO:0000313|EMBL:AAH79624.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH79624.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH79624.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., RA Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M., RA Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., RA Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., RA Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., RA Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., RA Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., RA Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., RA Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., RA Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., RA Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., RA Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., RA Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., RA Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., RA Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., RA Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., RA Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is CC mediated by G proteins which inhibit adenylyl cyclase. CC {ECO:0000256|ARBA:ARBA00025048, ECO:0000256|RuleBase:RU201114}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651, CC ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU201114}. CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU201114}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC079624; AAH79624.1; -; mRNA. DR RefSeq; NP_001278857.1; NM_001291928.1. DR AlphaFoldDB; Q6AXD8; -. DR DNASU; 11539; -. DR GeneID; 11539; -. DR AGR; MGI:99401; -. DR CTD; 134; -. DR MGI; MGI:99401; Adora1. DR OrthoDB; 2909020at2759; -. DR BioGRID-ORCS; 11539; 4 hits in 80 CRISPR screens. DR ChiTaRS; Adora1; mouse. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:UniProtKB-UniRule. DR GO; GO:0010646; P:regulation of cell communication; IEA:UniProt. DR GO; GO:0023051; P:regulation of signaling; IEA:UniProt. DR CDD; cd15071; 7tmA_Adenosine_R_A1; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR001068; Adeno_A1_rcpt. DR InterPro; IPR001634; Adenosn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR24246:SF1; ADENOSINE RECEPTOR A1; 1. DR PANTHER; PTHR24246; OLFACTORY RECEPTOR AND ADENOSINE RECEPTOR; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00552; ADENOSINEA1R. DR PRINTS; PR00424; ADENOSINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR SMART; SM01381; 7TM_GPCR_Srsx; 1. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|RuleBase:RU201114}; KW Disulfide bond {ECO:0000256|RuleBase:RU201114}; KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040, KW ECO:0000256|RuleBase:RU201114}; KW Glycoprotein {ECO:0000256|RuleBase:RU201114}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU201114}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU201114}; KW Transducer {ECO:0000256|RuleBase:RU201114}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU201114}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 12..33 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT TRANSMEM 45..69 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT TRANSMEM 75..103 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT TRANSMEM 124..146 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT TRANSMEM 185..207 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT TRANSMEM 232..248 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT TRANSMEM 268..290 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU201114" FT DOMAIN 26..288 FT /note="G-protein coupled receptors family 1 profile" FT /evidence="ECO:0000259|PROSITE:PS50262" SQ SEQUENCE 326 AA; 36666 MW; AB3A01D57483408E CRC64; MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILVLLA IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS EVEQAWIANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL KIWNDHFRCQ PKPPIEEDIP EEKADD //