ID   Q6AXD8_MOUSE            Unreviewed;       326 AA.
AC   Q6AXD8;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   16-JAN-2019, entry version 83.
DE   RecName: Full=Adenosine receptor A1 {ECO:0000256|RuleBase:RU201114};
GN   Name=Adora1 {ECO:0000313|EMBL:AAH79624.1, ECO:0000313|MGI:MGI:99401};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH79624.1};
RN   [1] {ECO:0000313|EMBL:AAH79624.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH79624.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH79624.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC       mediated by G proteins which inhibit adenylyl cyclase.
CC       {ECO:0000256|RuleBase:RU201114}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU201114}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU201114}.
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DR   EMBL; BC079624; AAH79624.1; -; mRNA.
DR   RefSeq; NP_001278857.1; NM_001291928.1.
DR   UniGene; Mm.298908; -.
DR   ProteinModelPortal; Q6AXD8; -.
DR   GeneID; 11539; -.
DR   CTD; 134; -.
DR   MGI; MGI:99401; Adora1.
DR   eggNOG; KOG3656; Eukaryota.
DR   eggNOG; ENOG410XRW9; LUCA.
DR   HOVERGEN; HBG106962; -.
DR   OrthoDB; 550297at2759; -.
DR   ChiTaRS; Adora1; mouse.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001609; F:G protein-coupled adenosine receptor activity; IEA:UniProtKB-UniRule.
DR   InterPro; IPR001068; Adeno_A1_rcpt.
DR   InterPro; IPR001634; Adenosn_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00552; ADENOSINEA1R.
DR   PRINTS; PR00424; ADENOSINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|RuleBase:RU201114};
KW   Disulfide bond {ECO:0000256|RuleBase:RU201114};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU201114};
KW   Glycoprotein {ECO:0000256|RuleBase:RU201114};
KW   Membrane {ECO:0000256|RuleBase:RU201114};
KW   Receptor {ECO:0000256|RuleBase:RU201114};
KW   Transducer {ECO:0000256|RuleBase:RU201114};
KW   Transmembrane {ECO:0000256|RuleBase:RU201114};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM     12     33       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM     45     69       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM     75    103       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    124    146       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    185    207       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    232    248       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    268    290       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   DOMAIN       26    288       G_PROTEIN_RECEP_F1_2.
FT                                {ECO:0000259|PROSITE:PS50262}.
SQ   SEQUENCE   326 AA;  36666 MW;  AB3A01D57483408E CRC64;
     MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA
     LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILVLLA IAVDRYLRVK IPLRYKTVVT
     QRRAAVAIAG CWILSLVVGL TPMFGWNNLS EVEQAWIANG SVGEPVIKCE FEKVISMEYM
     VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL
     FLFALSWLPL HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
     KIWNDHFRCQ PKPPIEEDIP EEKADD
//