ID Q6AXD8_MOUSE Unreviewed; 326 AA. AC Q6AXD8; DT 13-SEP-2004, integrated into UniProtKB/TrEMBL. DT 13-SEP-2004, sequence version 1. DT 09-DEC-2015, entry version 73. DE RecName: Full=Adenosine receptor A1 {ECO:0000256|RuleBase:RU201114}; GN Name=Adora1 {ECO:0000313|EMBL:AAH79624.1, ECO:0000313|MGI:MGI:99401}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH79624.1}; RN [1] {ECO:0000313|EMBL:AAH79624.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH79624.1}; RC TISSUE=Brain {ECO:0000313|EMBL:AAH79624.1}; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RA Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., RA Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., RA Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., RA Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., RA Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., RA Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., RA Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., RA Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., RA Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., RA Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., RA Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., RA Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., RA Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., RA Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., RA Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., RA Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., RA Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., RA Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., RA Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., RA Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., RA Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., RA Makowski K.A., Bosak S., Malek J.; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Receptor for adenosine. The activity of this receptor is CC mediated by G proteins which inhibit adenylyl cyclase. CC {ECO:0000256|RuleBase:RU201114}. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|RuleBase:RU201114}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU201114}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU201114}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC079624; AAH79624.1; -; mRNA. DR RefSeq; NP_001278857.1; NM_001291928.1. DR UniGene; Mm.298908; -. DR ProteinModelPortal; Q6AXD8; -. DR STRING; 10090.ENSMUSP00000043522; -. DR PaxDb; Q6AXD8; -. DR GeneID; 11539; -. DR CTD; 134; -. DR MGI; MGI:99401; Adora1. DR eggNOG; ENOG410XRW9; LUCA. DR eggNOG; KOG3656; Eukaryota. DR HOVERGEN; HBG106962; -. DR ChiTaRS; Adora1; mouse. DR GO; GO:0043197; C:dendritic spine; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0045202; C:synapse; IDA:MGI. DR GO; GO:0001609; F:G-protein coupled adenosine receptor activity; IEA:InterPro. DR GO; GO:0060079; P:excitatory postsynaptic potential; IDA:MGI. DR GO; GO:0050728; P:negative regulation of inflammatory response; IGI:MGI. DR GO; GO:0002686; P:negative regulation of leukocyte migration; IGI:MGI. DR GO; GO:1900453; P:negative regulation of long term synaptic depression; IMP:MGI. DR GO; GO:0070256; P:negative regulation of mucus secretion; IGI:MGI. DR GO; GO:0003093; P:regulation of glomerular filtration; IMP:MGI. DR InterPro; IPR001068; Adeno_A1_rcpt. DR InterPro; IPR001634; Adenosn_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00552; ADENOSINEA1R. DR PRINTS; PR00424; ADENOSINER. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|RuleBase:RU201114}; KW Disulfide bond {ECO:0000256|RuleBase:RU201114}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU201114}; KW Glycoprotein {ECO:0000256|RuleBase:RU201114}; KW Membrane {ECO:0000256|RuleBase:RU201114}; KW Receptor {ECO:0000256|RuleBase:RU201114}; KW Transducer {ECO:0000256|RuleBase:RU201114}; KW Transmembrane {ECO:0000256|RuleBase:RU201114}; KW Transmembrane helix {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 12 33 Helical. {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 45 69 Helical. {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 75 103 Helical. {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 124 146 Helical. {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 185 207 Helical. {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 232 248 Helical. {ECO:0000256|RuleBase:RU201114}. FT TRANSMEM 268 290 Helical. {ECO:0000256|RuleBase:RU201114}. FT DOMAIN 26 288 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 326 AA; 36666 MW; AB3A01D57483408E CRC64; MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILVLLA IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS EVEQAWIANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL KIWNDHFRCQ PKPPIEEDIP EEKADD //