ID   Q6AXD8_MOUSE            Unreviewed;       326 AA.
AC   Q6AXD8;
DT   13-SEP-2004, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2004, sequence version 1.
DT   14-OCT-2015, entry version 71.
DE   RecName: Full=Adenosine receptor A1 {ECO:0000256|RuleBase:RU201114};
GN   Name=Adora1 {ECO:0000313|EMBL:AAH79624.1, ECO:0000313|MGI:MGI:99401};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH79624.1};
RN   [1] {ECO:0000313|EMBL:AAH79624.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6 {ECO:0000313|EMBL:AAH79624.1};
RC   TISSUE=Brain {ECO:0000313|EMBL:AAH79624.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M.,
RA   Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S.,
RA   Feolo M., Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F.,
RA   Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J.,
RA   Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N.,
RA   Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B.,
RA   Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B.,
RA   Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S.,
RA   Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R.,
RA   Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L.,
RA   Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E.,
RA   Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D.,
RA   Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G.,
RA   Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J.,
RA   Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L.,
RA   Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D.,
RA   Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A.,
RA   Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S.,
RA   Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Receptor for adenosine. The activity of this receptor is
CC       mediated by G proteins which inhibit adenylyl cyclase.
CC       {ECO:0000256|RuleBase:RU201114}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU201114}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU201114}.
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DR   EMBL; BC079624; AAH79624.1; -; mRNA.
DR   RefSeq; NP_001278857.1; NM_001291928.1.
DR   UniGene; Mm.298908; -.
DR   ProteinModelPortal; Q6AXD8; -.
DR   STRING; 10090.ENSMUSP00000043522; -.
DR   GeneID; 11539; -.
DR   CTD; 134; -.
DR   MGI; MGI:99401; Adora1.
DR   HOVERGEN; HBG106962; -.
DR   ChiTaRS; Adora1; mouse.
DR   GO; GO:0043197; C:dendritic spine; IDA:MGI.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045202; C:synapse; IDA:MGI.
DR   GO; GO:0001609; F:G-protein coupled adenosine receptor activity; IEA:InterPro.
DR   GO; GO:0060079; P:excitatory postsynaptic potential; IDA:MGI.
DR   GO; GO:0050728; P:negative regulation of inflammatory response; IGI:MGI.
DR   GO; GO:0002686; P:negative regulation of leukocyte migration; IGI:MGI.
DR   GO; GO:1900453; P:negative regulation of long term synaptic depression; IMP:MGI.
DR   GO; GO:0070256; P:negative regulation of mucus secretion; IGI:MGI.
DR   GO; GO:0003093; P:regulation of glomerular filtration; IMP:MGI.
DR   InterPro; IPR001068; Adeno_A1_rcpt.
DR   InterPro; IPR001634; Adenosn_rcpt.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00552; ADENOSINEA1R.
DR   PRINTS; PR00424; ADENOSINER.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond {ECO:0000256|RuleBase:RU201114};
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU201114};
KW   Glycoprotein {ECO:0000256|RuleBase:RU201114};
KW   Membrane {ECO:0000256|RuleBase:RU201114};
KW   Receptor {ECO:0000256|RuleBase:RU201114};
KW   Transducer {ECO:0000256|RuleBase:RU201114};
KW   Transmembrane {ECO:0000256|RuleBase:RU201114};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM     12     33       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM     45     69       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM     75    103       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    124    146       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    185    207       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    232    248       Helical. {ECO:0000256|RuleBase:RU201114}.
FT   TRANSMEM    268    290       Helical. {ECO:0000256|RuleBase:RU201114}.
SQ   SEQUENCE   326 AA;  36666 MW;  AB3A01D57483408E CRC64;
     MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS LAVADVAVGA
     LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILVLLA IAVDRYLRVK IPLRYKTVVT
     QRRAAVAIAG CWILSLVVGL TPMFGWNNLS EVEQAWIANG SVGEPVIKCE FEKVISMEYM
     VYFNFFVWVL PPLLLMVLIY LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL
     FLFALSWLPL HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
     KIWNDHFRCQ PKPPIEEDIP EEKADD
//