ID PZRN3_MOUSE Reviewed; 1063 AA. AC Q69ZS0; Q91Z03; Q9QY54; Q9QY55; DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-2005, sequence version 2. DT 10-FEB-2009, entry version 48. DE RecName: Full=PDZ domain-containing RING finger protein 3; DE AltName: Full=Semaphorin cytoplasmic domain-associated protein 3; DE Short=Protein SEMACAP3; GN Name=Pdzrn3; Synonyms=Kiaa1095, Semcap3; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). RA Wang L.-H., Strittmatter S.M.; RT "Cloning and characterization of a novel PDZ domain containing protein RT interacting with the transmembrane semaphorin, M-semF."; RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-1063 (ISOFORM 1). RC TISSUE=Fetal brain; RX PubMed=15368895; DOI=10.1093/dnares/11.3.205; RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., RA Nagase T., Ohara O., Koga H.; RT "Prediction of the coding sequences of mouse homologues of KIAA gene: RT IV. The complete nucleotide sequences of 500 mouse KIAA-homologous RT cDNAs identified by screening of terminal sequences of cDNA clones RT randomly sampled from size-fractionated libraries."; RL DNA Res. 11:205-218(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 392-1063. RC STRAIN=FVB/N; TISSUE=Mammary tumor; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- SUBUNIT: Interacts with NLGN1 and EFNB2 (By similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; Synonyms=Pdzrn3A, 3B; CC IsoId=Q69ZS0-1; Sequence=Displayed; CC Name=2; Synonyms=Pdzrn3B, 3B; CC IsoId=Q69ZS0-2; Sequence=VSP_012610; CC -!- SIMILARITY: Contains 2 PDZ (DHR) domains. CC -!- SIMILARITY: Contains 1 RING-type zinc finger. CC -!- SIMILARITY: Contains 1 TRAF-type zinc finger. CC -!- SEQUENCE CAUTION: CC Sequence=AAH10329.1; Type=Erroneous termination; Positions=408; Note=Translated as Gln; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF127084; AAF22131.1; -; mRNA. DR EMBL; AF127085; AAF22132.1; -; mRNA. DR EMBL; AK173098; BAD32376.1; -; mRNA. DR EMBL; BC010329; AAH10329.1; ALT_SEQ; mRNA. DR IPI; IPI00135609; -. DR IPI; IPI00551426; -. DR RefSeq; NP_061372.1; -. DR UniGene; Mm.321654; -. DR HSSP; Q12959; 1PDR. DR SMR; Q69ZS0; 248-339, 404-515. DR PhosphoSite; Q69ZS0; -. DR Ensembl; ENSMUSG00000035357; Mus musculus. DR GeneID; 55983; -. DR KEGG; mmu:55983; -. DR MGI; MGI:1933157; Pdzrn3. DR HOGENOM; Q69ZS0; -. DR HOVERGEN; Q69ZS0; -. DR NextBio; 311690; -. DR ArrayExpress; Q69ZS0; -. DR Bgee; Q69ZS0; -. DR CleanEx; MM_PDZRN3; -. DR GermOnline; ENSMUSG00000035357; Mus musculus. DR GO; GO:0005515; F:protein binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR InterPro; IPR001478; PDZ. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR InterPro; IPR001293; Znf_TRAF. DR Gene3D; G3DSA:3.30.40.10; Znf_RING/FYVE/PHD; 1. DR Pfam; PF00595; PDZ; 2. DR Pfam; PF00097; zf-C3HC4; 1. DR Pfam; PF02176; zf-TRAF; 1. DR SMART; SM00228; PDZ; 2. DR SMART; SM00184; RING; 1. DR PROSITE; PS50106; PDZ; 2. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. DR PROSITE; PS50145; ZF_TRAF; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Coiled coil; Metal-binding; Repeat; Zinc; KW Zinc-finger. FT CHAIN 1 1063 PDZ domain-containing RING finger protein FT 3. FT /FTId=PRO_0000055918. FT DOMAIN 249 339 PDZ 1. FT DOMAIN 419 503 PDZ 2. FT ZN_FING 18 56 RING-type; degenerate. FT ZN_FING 100 158 TRAF-type. FT COILED 680 705 Potential. FT COMPBIAS 986 989 Poly-Arg. FT VAR_SEQ 82 133 Missing (in isoform 2). FT /FTId=VSP_012610. FT CONFLICT 82 82 C -> R (in Ref. 2; BAD32376). FT CONFLICT 199 199 L -> V (in Ref. 2; BAD32376). FT CONFLICT 596 596 S -> Y (in Ref. 1; AAF22131/AAF22132). FT CONFLICT 731 731 N -> Y (in Ref. 1; AAF22131/AAF22132). FT CONFLICT 823 823 A -> S (in Ref. 3; AAH10329). FT CONFLICT 912 912 V -> A (in Ref. 3; AAH10329). FT CONFLICT 938 938 R -> K (in Ref. 1; AAF22131/AAF22132). SQ SEQUENCE 1063 AA; 119415 MW; 7944EC1659D680F0 CRC64; MGFELDRFDG DVDPDLKCAL CHKVLEDPLT TPCGHVFCAG CVLPWVVQEG SCPARCRGRL SAKELNHVLP LKRLILKLDI KCAHAARGCG RVVKLQDLPE HLERCDFAPA RCRHAGCGQL LLRRDVEAHM RDACDARPVG RCQEGCGLPL THGEQRAGGH CCARALRAHN GALQARLGAL HKALKKEALR AGKREKSLLA QLAAAQLELQ MTALRYQKKF TEYSARLDSL SRCVAAPPGG KGEETKSLTL VLHRDSGSLG FNIIGGRPCV DNQDGSSSEG IFVSKIVDSG PAAKEGGLQI HDRIIEVNGK DLSRATHDQA VEAFKTAKEP IVVQVLRRTP RTKMFTPASE SQLVDTGTQT DITFEHIMAL TKMSSPSPPV LDPYLLPEEH PASHDYYDPN DYMGDIHQDM DREELELEEV GLYRMNSQDK LGLTVCYRTD DEDDIGIYIS EIDPNSIAAK DGRIREGDRI IQINGIEVQN REEAVALLTS EENKNFSLLI ARPELQLDEG WMDDDRNDFL DDLHMDMLEE QHHQAMQFTA SVLQQKKHEE DGGTTDTATI LSNQHEKDSG VGRTDESTRN DESSEQENNG EDATASANPL AGQRKLTCSQ DTLGSGDLPF SNESFISADC TDVDYLGIPE DECERFRELL ELKCQVQSAS PYSLYYPSSP LDAAGKSDPE SVDKELELLN EELRSIELEC LSIVRAHKMQ QLKEQYRESW MLHHSGFRNY NTSVDVRRHE LSDITELPEK SDKDSSSAYN TGESCRSTPL TLEISPDNSL RRVAEGSSEG ATANIEAYRP SPKNLLAITE DPEVSTPSYN PSAKELDPSQ ALEIKERRGS DGSRSPTASP KLGNAYLPSY HHSPYKHAHI PAHAQHYQSY MHLIQQKSAV EYAQSQMSLV SMCKDLNSSN SVEPRMEWKV KIRSDGTRYI TKRPVRDRLL RERALKIREE RSGLTTDDDA MSEMKMGRYW SKEERKQHLV KAKEQRRRRE FMMQSRLDCL KEQQASDDRK EMNILELSHK KMMKKRNKKI FDNWMTIQEL LTHGTKSPDG TRVYNSFLSV TTV //