ID   Q69569      PRELIMINARY;      PRT;   114 AA.
AC   Q69569;
DT   01-NOV-1996 (TREMBLREL. 01, CREATED)
DT   01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE)
DT   01-NOV-1998 (TREMBLREL. 08, LAST ANNOTATION UPDATE)
DE   (HHV-6).
GN   U91.
OS   HUMAN HERPESVIRUS-6.
OC   VIRUSES; DSDNA VIRUSES, NO RNA STAGE; HERPESVIRIDAE; BETAHERPESVIRINAE;
OC   ROSEOLOVIRUS.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 95266321.
RA   GOMPELS U.A., NICHOLAS J., LAWRENCE G., JONES M., THOMSON B.J.,
RA   MARTIN M.E., EFSTATHIOU S., CRAXTON M., MACAULAY H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content,
RT   and genome evolution.";
RL   VIROLOGY 209:29-51(1995).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 90080132.
RA   LAWRENCE G.L., CHEE M., CRAXTON M.A., GOMPELS U.A., HONESS R.W.,
RA   BARRELL B.G.;
RT   "Human herpesvirus 6 is closely related to human cytomegalovirus.";
RL   J. VIROL. 64:287-299(1990).
RN   [3]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 91237802.
RA   CHANG C.K., BALACHANDRAN N.;
RT   "Identification, characterization, and sequence analysis of a cDNA
RT   encoding a phosphoprotein of human herpesvirus 6.";
RL   J. VIROL. 65:2884-2894(1991).
RN   [4]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 91333007.
RA   TEO I.A., GRIFFIN B.E., JONES M.D.;
RT   "Characterization of the DNA polymerase gene of human herpesvirus
RT   6.";
RL   J. VIROL. 65:4670-4680(1991).
RN   [5]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 91226542.
RA   THOMSON B.J., EFSTATHIOU S., HONESS R.W.;
RT   "Acquisition of the human adeno-associated virus type-2 rep gene by
RT   human herpesvirus type-6.";
RL   NATURE 351:78-80(1991).
RN   [6]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 91374590.
RA   MARTIN M.E.D., NICHOLAS J., THOMSON B.J., NEWMAN C., HONESS R.W.;
RT   "Identification of a transactivating function mapping to the putative
RT   immediate-early locus of human herpesvirus 6.";
RL   J. VIROL. 65:5381-5390(1991).
RN   [7]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 92333249.
RA   EFSTATHIOU S., LAWRENCE G.L., BROWN C.M., BARRELL B.G.;
RT   "Identification of homologues to the human cytomegalovirus US22 gene
RT   family in human herpesvirus 6.";
RL   J. GEN. VIROL. 73:1661-1671(1992).
RN   [8]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 92148942.
RA   GENG Y., CHANDRAN B., JOSEPHS S.F., WOOD C.;
RT   "Identification and characterization of a human herpesvirus 6 gene
RT   segment that trans activates the human immunodeficiency virus type 1
RT   promoter.";
RL   J. VIROL. 66:1564-1570(1992).
RN   [9]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 93091236.
RA   GOMPELS U.A., CARSS A.L., SUN N., ARRAND J.R.;
RT   "Infectivity determinants encoded in a conserved gene block of human
RT   herpesvirus-6.";
RL   DNA SEQ. 3:25-39(1992).
RN   [10]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 92260671.
RA   NEIPEL F., ELLINGER K., FLECKENSTEIN B.;
RT   "Gene for the major antigenic structural protein (p100) of human
RT   herpesvirus 6.";
RL   J. VIROL. 66:3918-3924(1992).
RN   [11]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 92333248.
RA   THOMSON B.J., HONESS R.W.;
RT   "The right end of the unique region of the genome of human
RT   herpesvirus 6 U1102 contains a candidate immediate early gene
RT   enhancer and a homologue of the human cytomegalovirus US22 gene
RT   family.";
RL   J. GEN. VIROL. 73:1649-1660(1992).
RN   [12]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 93187613.
RA   ELLINGER K., NEIPEL F., FOA-TOMASI L., CAMPADELLI-FIUME G.,
RA   FLECKENSTEIN B.;
RT   "The glycoprotein B homologue of human herpesvirus 6.";
RL   J. GEN. VIROL. 74:495-500(1993).
RN   [13]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 93224882.
RA   GOMPELS U.A., CARRIGAN D.R., CARSS A.L., ARNO J.;
RT   "Two groups of human herpesvirus 6 identified by sequence analyses of
RT   laboratory strains and variants from Hodgkin's lymphoma and bone
RT   marrow transplant patients.";
RL   J. GEN. VIROL. 74:613-622(1993).
RN   [14]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 93389439.
RA   LIU D.X., GOMPELS U.A., NICHOLAS J., LELLIOTT C.;
RT   "Identification and expression of the human herpesvirus 6
RT   glycoprotein H and interaction with an accessory 40K glycoprotein.";
RL   J. GEN. VIROL. 74:1847-1857(1993).
RN   [15]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94025558.
RA   LIU D.X., GOMPELS U.A., FOA-TOMASI L., CAMPADELLI-FIUME G.;
RT   "Human herpesvirus-6 glycoprotein H and L homologs are components of
RT   the gp100 complex and the gH external domain is the target for
RT   neutralizing monoclonal antibodies.";
RL   VIROLOGY 197:12-22(1993).
RN   [16]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 93331710.
RA   PELLETT P.E., SANCHEZ-MARTINEZ D., DOMINGUEZ G., BLACK J.B., ANTON E.,
RA   GREENAMOYER C., DAMBAUGH T.R.;
RT   "A strongly immunoreactive virion protein of human herpesvirus 6
RT   variant B strain Z29: identification and characterization of the gene
RT   and mapping of a variant-specific monoclonal antibody reactive
RT   epitope.";
RL   VIROLOGY 195:521-531(1993).
RN   [17]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 93323202.
RA   PFEIFFER B., BERNEMAN Z.N., NEIPEL F., CHANG C.K., TIRWATNAPONG S.,
RA   CHANDRAN B.;
RT   "Identification and mapping of the gene encoding the glycoprotein
RT   complex gp82-gp105 of human herpesvirus 6 and mapping of the
RT   neutralizing epitope recognized by monoclonal antibodies.";
RL   J. VIROL. 67:4611-4620(1993).
RN   [18]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 95146989.
RA   GOMPELS U.A., MACAULAY H.A.;
RT   "Characterization of human telomeric repeat sequences from human
RT   herpesvirus 6 and relationship to replication.";
RL   J. GEN. VIROL. 76:451-458(1995).
RN   [19]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94047392.
RA   DEWHURST S., DOLLARD S.C., PELLETT P.E., DAMBAUGH T.R.;
RT   "Identification of a lytic-phase origin of DNA replication in human
RT   herpesvirus 6B strain Z29.";
RL   J. VIROL. 67:7680-7683(1993).
RN   [20]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RA   NICHOLAS J.;
RL   SUBMITTED (JUN-1995) TO EMBL/GENBANK/DDBJ DATA BANKS.
RN   [21]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94118404.
RA   NICHOLAS J., MARTIN M.;
RT   "Nucleotide sequence analysis of a 38.5-kilobase-pair region of the
RT   genome of human herpesvirus 6 encoding human cytomegalovirus
RT   immediate-early gene homologs and transactivating functions.";
RL   J. VIROL. 68:597-610(1994).
RN   [22]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94202284.
RA   SCHIEWE U., NEIPEL F., SCHREINER D., FLECKENSTEIN B.;
RT   "Structure and transcription of an immediate-early region in the
RT   human herpesvirus 6 genome.";
RL   J. VIROL. 68:2978-2985(1994).
RN   [23]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94181269.
RA   THOMPSON J., CHOUDHURY S., KASHANCHI F., DONIGER J., BERNEMAN Z.,
RA   FRENKEL N., ROSENTHAL L.J.;
RT   "A transforming fragment within the direct repeat region of human
RT   herpesvirus type 6 that transactivates HIV-1.";
RL   ONCOGENE 9:1167-1175(1994).
RN   [24]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94167865.
RA   ZHOU Y., CHANG C.K., QIAN G., CHANDRAN B., WOOD C.;
RT   "trans-activation of the HIV promoter by a cDNA and its genomic
RT   clones of human herpesvirus-6.";
RL   VIROLOGY 199:311-322(1994).
RN   [25]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94202288.
RA   THOMSON B.J., DEWHURST S., GRAY D.;
RT   "Structure and heterogeneity of the a sequences of human herpesvirus
RT   6 strain variants U1102 and Z29 and identification of human telomeric
RT   repeat sequences at the genomic termini.";
RL   J. VIROL. 68:3007-3014(1994).
RN   [26]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94378506.
RA   THOMSON B.J., WEINDLER F.W., GRAY D., SCHWAAB V., HELBRONN R.;
RT   "Human herpesvirus 6 (HHV-6) is a helper virus for adeno-associated
RT   virus type 2 (AAV-2) and the AAV-2 rep gene homologue in HHV-6 can
RT   mediate AAV-2 DNA replication and regulate gene expression.";
RL   VIROLOGY 204:304-311(1994).
RN   [27]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94267872.
RA   INOUE N., DAMBAUGH T.R., RAPP J.C., PELLETT P.E.;
RT   "Alphaherpesvirus origin-binding protein homolog encoded by human
RT   herpesvirus 6B, a betaherpesvirus, binds to nucleotide sequences that
RT   are similar to ori regions of alphaherpesviruses.";
RL   J. VIROL. 68:4126-4136(1994).
RN   [28]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RA   LAWRENCE G.L., NICHOLAS J., BARRELL B.G.;
RL   J. GEN. VIROL. 0:0-0(1994).
RN   [29]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RA   QIAN G., WOOD C., CHANDRAN B.;
RL   J. VIROL. 194:380-386(1993).
RN   [30]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 94025598.
RA   JONES M., TEO I.;
RT   "Identification and analysis of the transport/capsid assembly protein
RT   (tp/cap) gene of human herpesvirus-6 (HHV6).";
RL   VIROLOGY 197:449-454(1993).
RN   [31]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 90112641.
RA   LITTLER E., LAWRENCE G., LIU M.Y., BARRELL B.G., ARRAND J.R.;
RT   "Identification, cloning, and expression of the major capsid protein
RT   gene of human herpesvirus 6.";
RL   J. VIROL. 64:714-722(1990).
RN   [32]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 91116306.
RA   MARTIN M., THOMSON B.J., HONESS R.W., CRAXTON M.A., GOMPELS U.A.,
RA   LIU M.Y., LITTLER E., ARRAND J.R., TEO I., JONES M.D.;
RT   "The genome of human herpesvirus 6: maps of unit-length and
RT   concatemeric genomes for nine restriction endonucleases.";
RL   J. GEN. VIROL. 72:157-168(1991).
RN   [33]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RX   MEDLINE; 89279291.
RA   CHEE M.S., LAWRENCE G.L., BARRELL B.G.;
RT   "Alpha-, beta- and gammaherpesviruses encode a putative
RT   phosphotransferase.";
RL   J. GEN. VIROL. 70:1151-1160(1989).
RN   [34]
RP   SEQUENCE FROM N.A.
RC   STRAIN=U1102, VARIANT A;
RA   GOMPELS U.A.;
RL   SUBMITTED (DEC-1994) TO EMBL/GENBANK/DDBJ DATA BANKS.
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DR   EMBL; X83413; E138111; -.
SQ   SEQUENCE   114 AA;  12897 MW;  48E3D9F0 CRC32;
     RICLFYFNVL IIYLHTFLKN EKKNITDGLF LDSVTSQAME NKESMKKNEG EPPVWIQALT
     TTLSIILLVC IIMACIICSR TTEEEKSEMQ SSASSVETLQ SLNEAIFPKG EMNV
//