ID Q68FI4_XENLA Unreviewed; 150 AA. AC Q68FI4; DT 11-OCT-2004, integrated into UniProtKB/TrEMBL. DT 11-OCT-2004, sequence version 1. DT 07-JUN-2017, entry version 70. DE RecName: Full=Actin-related protein 2/3 complex subunit 5 {ECO:0000256|RuleBase:RU004301}; GN Name=arpc5 {ECO:0000313|Xenbase:XB-GENE-866317}; GN Synonyms=MGC86407 {ECO:0000313|EMBL:AAH79805.1}; GN ORFNames=XELAEV_18023257mg {ECO:0000313|EMBL:OCT85093.1}; OS Xenopus laevis (African clawed frog). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; OC Xenopus. OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH79805.1}; RN [1] {ECO:0000313|EMBL:AAH79805.1} RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Kidney {ECO:0000313|EMBL:AAH79805.1}; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ABL63901.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=17178911; DOI=10.1083/jcb.200604176; RA Miyoshi T., Tsuji T., Higashida C., Hertzog M., Fujita A., RA Narumiya S., Scita G., Watanabe N.; RT "Actin turnover-dependent fast dissociation of capping protein in the RT dendritic nucleation actin network: evidence of frequent filament RT severing."; RL J. Cell Biol. 175:947-955(2006). RN [3] {ECO:0000313|Proteomes:UP000186698} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=J {ECO:0000313|Proteomes:UP000186698}; RX PubMed=27762356; DOI=10.1038/nature19840; RA Session A.M., Uno Y., Kwon T., Chapman J.A., Toyoda A., Takahashi S., RA Fukui A., Hikosaka A., Suzuki A., Kondo M., van Heeringen S.J., RA Quigley I., Heinz S., Ogino H., Ochi H., Hellsten U., Lyons J.B., RA Simakov O., Putnam N., Stites J., Kuroki Y., Tanaka T., Michiue T., RA Watanabe M., Bogdanovic O., Lister R., Georgiou G., Paranjpe S.S., RA van Kruijsbergen I., Shu S., Carlson J., Kinoshita T., Ohta Y., RA Mawaribuchi S., Jenkins J., Grimwood J., Schmutz J., Mitros T., RA Mozaffari S.V., Suzuki Y., Haramoto Y., Yamamoto T.S., Takagi C., RA Heald R., Miller K., Haudenschild C., Kitzman J., Nakayama T., RA Izutsu Y., Robert J., Fortriede J., Burns K., Lotay V., Karimi K., RA Yasuoka Y., Dichmann D.S., Flajnik M.F., Houston D.W., Shendure J., RA DuPasquier L., Vize P.D., Zorn A.M., Ito M., Marcotte E.M., RA Wallingford J.B., Ito Y., Asashima M., Ueno N., Matsuda Y., RA Veenstra G.J., Fujiyama A., Harland R.M., Taira M., Rokhsar D.S.; RT "Genome evolution in the allotetraploid frog Xenopus laevis."; RL Nature 538:336-343(2016). RN [4] {ECO:0000313|EMBL:OCT85093.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=J {ECO:0000313|EMBL:OCT85093.1}; RC TISSUE=Blood {ECO:0000313|EMBL:OCT85093.1}; RA Session A., Uno Y., Kwon T., Chapman J., Toyoda A., Takahashi S., RA Fukui A., Hikosaka A., Putnam N., Stites J., Van Heeringen S., RA Quigley I., Heinz S., Hellsten U., Lyons J., Suzuki A., Kondo M., RA Ogino H., Ochi H., Bogdanovic O., Lister R., Georgiou G., Paranjpe S., RA Van Kruijsbergen I., Mozaffari S., Shu S., Schmutz J., Jenkins J., RA Grimwood J., Carlson J., Mitros T., Simakov O., Heald R., Miller K., RA Haudenschild C., Kuroki Y., Tanaka T., Michiue T., Watanabe M., RA Kinoshita T., Ohta Y., Mawaribuchi S., Suzuki Y., Haramoto Y., RA Yamamoto T., Takagi C., Kitzman J., Shendure J., Nakayama T., RA Izutsu Y., Robert J., Dichmann D., Flajnik M., Houston D., RA Marcotte E., Wallingford J., Ito Y., Asashima M., Ueno N., Matsuda Y., RA Jan Veenstra G., Fujiyama A., Harland R., Taira M., Rokhsar D.S.; RT "WGS assembly of Xenopus laevis."; RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Functions as component of the Arp2/3 complex which is CC involved in regulation of actin polymerization and together with CC an activating nucleation-promoting factor (NPF) mediates the CC formation of branched actin networks. CC {ECO:0000256|RuleBase:RU004301}. CC -!- SIMILARITY: Belongs to the ARPC5 family. CC {ECO:0000256|RuleBase:RU004301}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC079805; AAH79805.1; -; mRNA. DR EMBL; EF011868; ABL63901.1; -; mRNA. DR EMBL; CM004472; OCT85093.1; -; Genomic_DNA. DR RefSeq; NP_001087450.1; NM_001093981.1. DR UniGene; Xl.45915; -. DR IntAct; Q68FI4; 1. DR GeneID; 447274; -. DR KEGG; xla:447274; -. DR CTD; 447274; -. DR Xenbase; XB-GENE-866317; arpc5. DR HOVERGEN; HBG050583; -. DR KO; K05754; -. DR Proteomes; UP000186698; Chromosome 4l. DR GO; GO:0005885; C:Arp2/3 protein complex; IEA:InterPro. DR GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IEA:InterPro. DR Gene3D; 1.25.40.190; -; 1. DR InterPro; IPR006789; ARPC5. DR PANTHER; PTHR12644; PTHR12644; 1. DR Pfam; PF04699; P16-Arc; 1. DR PIRSF; PIRSF039096; p16-ARC; 1. DR SUPFAM; SSF69103; SSF69103; 1. PE 2: Evidence at transcript level; KW Complete proteome {ECO:0000313|Proteomes:UP000186698}; KW Cytoplasm {ECO:0000256|RuleBase:RU004301}; KW Cytoskeleton {ECO:0000256|RuleBase:RU004301}; KW Reference proteome {ECO:0000313|Proteomes:UP000186698}. SQ SEQUENCE 150 AA; 16400 MW; 686E7C42BBDF5726 CRC64; MAKNTVSARF RKVDVDEYDE NKFVDEEEAG EGQQGPDEGE VDSAIRGGNM MGALQAALKN PPINTKNQSA KDRAENLVLK VLISFKANEI EKAVQSLDKN STDLLMKYIY KGFESPSDNS SAVLLQWHEK ALAVAGVGSI VRVLTARKTV //