ID ATG9A_MOUSE Reviewed; 551 AA. AC Q68FE2; DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 11-OCT-2004, sequence version 1. DT 06-MAR-2013, entry version 59. DE RecName: Full=Autophagy-related protein 9A; DE AltName: Full=APG9-like 1; GN Name=Atg9a; Synonyms=Apg9l1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6; TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Plays a role in autophagy. Cycles between a juxta- CC nuclear trans-Golgi network compartment and late endosomes. CC Nutrient starvation induces accumulation on autophagosomes. CC Starvation-dependent trafficking requires ULK1, ATG13 and SUPT20H CC (By similarity). CC -!- SUBUNIT: Interacts with SUPT20H (By similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome membrane; CC Multi-pass membrane protein (By similarity). Golgi apparatus, CC trans-Golgi network membrane; Multi-pass membrane protein (By CC similarity). Late endosome membrane; Multi-pass membrane protein CC (By similarity). CC -!- MISCELLANEOUS: Isoform displayed in this entry matches to human CC isoform 3. CC -!- SIMILARITY: Belongs to the ATG9 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC079884; AAH79884.1; -; mRNA. DR IPI; IPI00461470; -. DR UniGene; Mm.358931; -. DR STRING; Q68FE2; -. DR PaxDb; Q68FE2; -. DR PRIDE; Q68FE2; -. DR MGI; MGI:2138446; Atg9a. DR eggNOG; NOG298729; -. DR ChiTaRS; ATG9A; mouse. DR CleanEx; MM_ATG9A; -. DR Genevestigator; Q68FE2; -. DR GermOnline; ENSMUSG00000033124; Mus musculus. DR GO; GO:0005776; C:autophagic vacuole; IDA:MGI. DR GO; GO:0000421; C:autophagic vacuole membrane; IEA:UniProtKB-SubCell. DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0000045; P:autophagic vacuole assembly; ISA:MGI. DR GO; GO:0045087; P:innate immune response; IMP:MGI. DR GO; GO:0034067; P:protein localization to Golgi apparatus; IMP:MGI. DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW. DR InterPro; IPR007241; Autophagy-rel_prot_9. DR PANTHER; PTHR13038; PTHR13038; 1. DR Pfam; PF04109; APG9; 1. PE 2: Evidence at transcript level; KW Autophagy; Complete proteome; Cytoplasmic vesicle; Endosome; KW Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein; KW Protein transport; Reference proteome; Transmembrane; KW Transmembrane helix; Transport. FT CHAIN 1 551 Autophagy-related protein 9A. FT /FTId=PRO_0000119821. FT TRANSMEM 73 93 Helical; (Potential). FT TRANSMEM 132 152 Helical; (Potential). FT TRANSMEM 290 310 Helical; (Potential). FT TRANSMEM 372 392 Helical; (Potential). FT TRANSMEM 401 421 Helical; (Potential). FT MOD_RES 18 18 Phosphoserine (By similarity). FT MOD_RES 524 524 Phosphoserine (By similarity). FT CARBOHYD 99 99 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 551 AA; 63138 MW; BDCDBA33E0D10C26 CRC64; MAQFDTEYQR LEASYSDSPP GEEDLLVHVA EGSKSPWHHI ENLDLFFSRV YNLHQKNGFT CMLIGEMFEL MQFLFVVAFT TFLVSCVDYD ILFANKMVNH SLHPTEPVKV TLPDAFLPAQ VCSARIQENG SLITILVIAG VFWIHRLIKF IYNICCYWEI HSFYLHALRI PMSALPYCTW QEVQARIVQT QKEHQICIHK RELTELDIYH RILRFQNYMV ALVNKSLLPL RFRLPGLGEV VFFTRGLKYN FELILFWGPG SLFLNEWSLK AEYKRGGQRL ELAQRLSNRI LWIGIANFLL CPLILIWQIL YAFFSYAEVL KREPGALGAR CWSLYGRCYL RHFNELEHEL QSRLNRGYKP ASKYMNCFLS PLLTLLAKNG AFFAGSILAV LIALTIYDED VLAVEHVLTT VTLLGVTVTV CRSFIPDQHM VFCPEQLLRV ILAHIHYMPD HWQGVHLGGV AESHRHTPHS HLLPPPSGPG DHRLLPQLYG RGRGCGRHLL LCSDGRSPAW PSSVAVWRAD RGLSVPASRG REDRVVAHAL CHHQSRLAAP S //