ID Q68DM7_HUMAN Unreviewed; 311 AA. AC Q68DM7; DT 11-OCT-2004, integrated into UniProtKB/TrEMBL. DT 11-OCT-2004, sequence version 1. DT 29-MAY-2024, entry version 79. DE SubName: Full=Uncharacterized protein DKFZp686G01261 {ECO:0000313|EMBL:CAH18193.1}; DE Flags: Fragment; GN Name=DKFZp686G01261 {ECO:0000313|EMBL:CAH18193.1}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:CAH18193.1}; RN [1] {ECO:0000313|EMBL:CAH18193.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Cerebellum {ECO:0000313|EMBL:CAH18193.1}; RG The German cDNA Consortium; RA Poustka A., Albert R., Moosmayer P., Schupp I., Wellenreuther R., RA Mewes H.W., Weil B., Amid C., Osanger A., Fobo G., Han M., Wiemann S.; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CR749340; CAH18193.1; -; mRNA. DR RefSeq; NP_001128686.1; NM_001135214.2. DR AlphaFoldDB; Q68DM7; -. DR PeptideAtlas; Q68DM7; -. DR DNASU; 9815; -. DR GeneID; 9815; -. DR CTD; 9815; -. DR DisGeNET; 9815; -. DR OrthoDB; 2877020at2759; -. DR BioGRID-ORCS; 9815; 17 hits in 1163 CRISPR screens. DR GenomeRNAi; 9815; -. DR GO; GO:0045202; C:synapse; IEA:TreeGrafter. DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro. DR GO; GO:0031267; F:small GTPase binding; IEA:TreeGrafter. DR GO; GO:0007420; P:brain development; IEA:InterPro. DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. DR GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0036465; P:synaptic vesicle recycling; IEA:TreeGrafter. DR Gene3D; 1.20.5.170; -; 1. DR Gene3D; 1.20.120.330; Nucleotidyltransferases domain 2; 1. DR InterPro; IPR047161; GIT-like. DR InterPro; IPR032352; GIT1/2_CC. DR InterPro; IPR022018; GIT1_C. DR PANTHER; PTHR46097:SF4; ARF GTPASE-ACTIVATING PROTEIN GIT2; 1. DR PANTHER; PTHR46097; G PROTEIN-COUPLED RECEPTOR KINASE INTERACTING ARFGAP; 1. DR Pfam; PF12205; GIT1_C; 1. DR Pfam; PF16559; GIT_CC; 1. PE 2: Evidence at transcript level; KW Coiled coil {ECO:0000256|SAM:Coils}. FT DOMAIN 1..60 FT /note="Arf GTPase-activating protein GIT1/2 coiled-coil" FT /evidence="ECO:0000259|Pfam:PF16559" FT DOMAIN 193..305 FT /note="ARF GTPase-activating protein GIT1 C-terminal" FT /evidence="ECO:0000259|Pfam:PF12205" FT REGION 62..194 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 19..60 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 62..85 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 131..146 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:CAH18193.1" SQ SEQUENCE 311 AA; 34661 MW; 5BC0CB7E6B48FCDC CRC64; DLSDGPVTVQ EFMEVKNALV ASEAKIQQLM KVNNNLSDEL RIMQKKLQTL QSENSNLRKQ ATTNVYQVQT GSEYTDTSNH SSLKRRPSAR GSRPMSMYET GSGQKPYLPM GEASRPEESR MRLQPFPAHA SRLEKQNSTP ESDYDNTPND MEPDGMGSSR KGRQRSMVWP GDGLVPDTAE PHVAPSPTLP STEDVIRKTE QITKNIQELL RAAQENKHDS YIPCSERIHV AVTEMAALFP KKPKSDMVRT SLRLLTSSAY RLQSECKKTL PGDPGSPTDV QLVTQQVIQC AYDIAKAAKQ LVTITTKENN N //