ID   Q672M3_PLAVI            Unreviewed;      1464 AA.
AC   Q672M3;
DT   11-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   11-OCT-2004, sequence version 1.
DT   10-MAY-2017, entry version 89.
DE   SubName: Full=Mdr1 {ECO:0000313|EMBL:AAU04972.1};
GN   Name=mdr1 {ECO:0000313|EMBL:AAU04972.1};
OS   Plasmodium vivax (malaria parasite P. vivax).
OC   Eukaryota; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX   NCBI_TaxID=5855 {ECO:0000313|EMBL:AAU04972.1};
RN   [1] {ECO:0000313|EMBL:AAU04972.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CL004 {ECO:0000313|EMBL:AAU04970.1}, and CL014
RC   {ECO:0000313|EMBL:AAU04972.1};
RA   Martha-Sa J., Nomura T., Wellems T.E., del Portillo H.A.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAU04972.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CL004 {ECO:0000313|EMBL:AAU04970.1}, and CL014
RC   {ECO:0000313|EMBL:AAU04972.1};
RX   PubMed=15755424; DOI=10.1016/j.exppara.2004.12.005;
RA   Sa J.M., Nomura T., Neves J., Baird J.K., Wellems T.E.,
RA   del Portillo H.A.;
RT   "Plasmodium vivax: allele variants of the mdr1 gene do not associate
RT   with chloroquine resistance among isolates from Brazil, Papua, and
RT   monkey-adapted strains.";
RL   Exp. Parasitol. 109:256-259(2005).
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DR   EMBL; AY571976; AAU04970.1; -; Genomic_DNA.
DR   EMBL; AY571978; AAU04972.1; -; Genomic_DNA.
DR   ProteinModelPortal; Q672M3; -.
DR   STRING; 5855.PVX_080100; -.
DR   eggNOG; KOG0055; Eukaryota.
DR   eggNOG; COG1132; LUCA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR003439; ABC_transporter-like.
DR   InterPro; IPR017871; ABC_transporter_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 3.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 4.
DR   SUPFAM; SSF90123; SSF90123; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PROSITE-ProRule:PRU00434};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU00434};
KW   Repeat {ECO:0000256|SAAS:SAAS00761389};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     61     87       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     99    124       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    197    217       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    281    301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    321    342       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    825    846       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    866    887       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    940    961       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    967    989       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1065   1086       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       64    350       ABC transmembrane type-1.
FT                                {ECO:0000259|PROSITE:PS50929}.
FT   DOMAIN      383    679       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   DOMAIN      826   1120       ABC transmembrane type-1.
FT                                {ECO:0000259|PROSITE:PS50929}.
FT   DOMAIN     1164   1461       ABC transporter. {ECO:0000259|PROSITE:
FT                                PS50893}.
FT   NP_BIND     418    425       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00434}.
FT   NP_BIND    1199   1206       ATP. {ECO:0000256|PROSITE-ProRule:
FT                                PRU00434}.
SQ   SEQUENCE   1464 AA;  165402 MW;  BA8EF4A50778BA7C CRC64;
     MKKDQRQPRD NSNSSNNLSI KDEVEKELNK KGTFELYKKI KTQKIPFFLP FKCLPSSHRK
     LLGVSFVCAT ISGGTLPFFV SVFGVIMKNM NLGENVNDII FSLVLIGIFQ FILSFISSFC
     MDVVTTKILK TLKIEFLKSV FYQDGQFHDN NPGSKLTSDL DFYLEQVNAG IGTKFITIFT
     YASAFLGLYI WSLFKNARLT LCITCVFPLI YICGVICNKK VKINKKTSLL YNNNTMSIIE
     EALVGIRTVV SYCGENTILK KFNLSEKLYS KYTLKANLME SLHIGMINGF ILASYAFGFW
     YGTRIIISDL SNQQPNNDFH GGSVISILLG VLISMFMLTI ILPNITEYMK SLEATNNLYE
     IINRKPLVEN NQDGKKLKDI KKIQFKNVRF HYDTRKDVEI YKDLNFTLTE GKTYAFVGES
     GCGKSTILKL IERLYDPTEG DVIINDSHNL KDVNLKWWRS KIGVVSQDPL LFSNSIKNNI
     KYSLYSLKDL EALSEESNED GFSSQSDSNS HNSCRAKCAG DLNDMIQTTD STELIQVRKN
     YETIEDSEVV SVSKKVLIHD FVSALPDKYE TLVGSNASKL SGGQKQRISI ARAIIRNPKI
     LILDEATSSL DNKSEYLVQK TINNLKGNEN RITIIIAHRL STIRYANTIF VLSNRENGST
     VDVDVLGEDP TKDSNEKNEK HDKQEKGGKN SSANQKISNA GSYIIEQGTH DALMKNKNGI
     YYTMINNQKV SSKSSSNNDN DKDSDMKSSI YKDSERGYDP DEANGNAKNE SASAKKSEKM
     SDAKASNTNA GGRLAFLRNL FKRKPKAPNN LRVVYREIFS YKEDIAIIAL SIMVAGGLYP
     LFALLYAKYV GTLFDFANLE ANSNKYSLYI LVIAIAMFIS ETLKNYYNNV IGEKVEKTMK
     LRLFENILYQ EISFFDQDSH APGLLSAHIN RDVHLLKTGL VNNIVIFTHF IVLFLVSMVM
     SFYFCPIVAA VLTGTFFIFM RVFAIRARIA ANKDVEKKRV NQPGTAFVYN SDDEIFKDPS
     FLIQEAFYNM NTVIIYGLED YFCTLIEKAI DYSNKGQKRK TLINSMLWGF SQSAQLFINS
     FAYWFGSFLI RRGTIQVDDF MKSFFTFLFT GSYAGKLMSL KGDSENAKLS FERYYPLITR
     KSLIDVRDNG GIKIKNSNDI KGKIEIMDVN FRYLSRPNVP IYKDLTFSCE SKKTTAIVGE
     TGSGKSTVMS LLMRFYDLKN DHHIVFKNEQ TGESSKEQMQ QGDEEQNVGM KNANEFSSSK
     EGADGQSSTL FKNSGKILLD GVDICDYNLK DLRNLFSIVS QEPMLFNMSI YENIKFGKEN
     ATREDVKRAC KFAAIDEFIE SLPNQYDTNV GPYGKSLSGG QKQRIAIARA LLREPKILLL
     DEATSSLDSN SEKLIEKTIV DIKDKADKTI ITIAHRIASI KRSDKIVVFN NPDRTGSFVQ
     AQGTHEELLS VQDGVYKKYV KLAK
//