ID Q672M3_PLAVI Unreviewed; 1464 AA. AC Q672M3; DT 11-OCT-2004, integrated into UniProtKB/TrEMBL. DT 11-OCT-2004, sequence version 1. DT 02-JUN-2021, entry version 105. DE SubName: Full=Mdr1 {ECO:0000313|EMBL:AAU04972.1}; GN Name=mdr1 {ECO:0000313|EMBL:AAU04972.1}; OS Plasmodium vivax (malaria parasite P. vivax). OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium). OX NCBI_TaxID=5855 {ECO:0000313|EMBL:AAU04972.1}; RN [1] {ECO:0000313|EMBL:AAU04972.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CL004 {ECO:0000313|EMBL:AAU04970.1}, and CL014 RC {ECO:0000313|EMBL:AAU04972.1}; RA Martha-Sa J., Nomura T., Wellems T.E., del Portillo H.A.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:AAU04972.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=CL004 {ECO:0000313|EMBL:AAU04970.1}, and CL014 RC {ECO:0000313|EMBL:AAU04972.1}; RX PubMed=15755424; DOI=10.1016/j.exppara.2004.12.005; RA Sa J.M., Nomura T., Neves J., Baird J.K., Wellems T.E., del Portillo H.A.; RT "Plasmodium vivax: allele variants of the mdr1 gene do not associate with RT chloroquine resistance among isolates from Brazil, Papua, and monkey- RT adapted strains."; RL Exp. Parasitol. 109:256-259(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY571976; AAU04970.1; -; Genomic_DNA. DR EMBL; AY571978; AAU04972.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IEA:InterPro. DR Gene3D; 1.20.1560.10; -; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR011527; ABC1_TM_dom. DR InterPro; IPR036640; ABC1_TM_sf. DR InterPro; IPR003439; ABC_transporter-like. DR InterPro; IPR017871; ABC_transporter_CS. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR039421; Type_1_exporter. DR PANTHER; PTHR24221; PTHR24221; 2. DR Pfam; PF00664; ABC_membrane; 2. DR Pfam; PF00005; ABC_tran; 3. DR SMART; SM00382; AAA; 2. DR SUPFAM; SSF52540; SSF52540; 3. DR SUPFAM; SSF90123; SSF90123; 2. DR PROSITE; PS50929; ABC_TM1F; 2. DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2. DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE- KW ProRule:PRU00434}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE- KW ProRule:PRU00434}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 61..87 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 99..124 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 171..191 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 197..217 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 281..301 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 321..342 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 825..846 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 866..887 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 940..961 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 967..989 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1065..1086 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 64..350 FT /note="ABC transmembrane type-1" FT /evidence="ECO:0000259|PROSITE:PS50929" FT DOMAIN 383..679 FT /note="ABC transporter" FT /evidence="ECO:0000259|PROSITE:PS50893" FT DOMAIN 826..1120 FT /note="ABC transmembrane type-1" FT /evidence="ECO:0000259|PROSITE:PS50929" FT DOMAIN 1164..1461 FT /note="ABC transporter" FT /evidence="ECO:0000259|PROSITE:PS50893" FT NP_BIND 418..425 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00434" FT NP_BIND 1199..1206 FT /note="ATP" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00434" FT REGION 661..695 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 730..787 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 666..689 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 736..763 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1464 AA; 165402 MW; BA8EF4A50778BA7C CRC64; MKKDQRQPRD NSNSSNNLSI KDEVEKELNK KGTFELYKKI KTQKIPFFLP FKCLPSSHRK LLGVSFVCAT ISGGTLPFFV SVFGVIMKNM NLGENVNDII FSLVLIGIFQ FILSFISSFC MDVVTTKILK TLKIEFLKSV FYQDGQFHDN NPGSKLTSDL DFYLEQVNAG IGTKFITIFT YASAFLGLYI WSLFKNARLT LCITCVFPLI YICGVICNKK VKINKKTSLL YNNNTMSIIE EALVGIRTVV SYCGENTILK KFNLSEKLYS KYTLKANLME SLHIGMINGF ILASYAFGFW YGTRIIISDL SNQQPNNDFH GGSVISILLG VLISMFMLTI ILPNITEYMK SLEATNNLYE IINRKPLVEN NQDGKKLKDI KKIQFKNVRF HYDTRKDVEI YKDLNFTLTE GKTYAFVGES GCGKSTILKL IERLYDPTEG DVIINDSHNL KDVNLKWWRS KIGVVSQDPL LFSNSIKNNI KYSLYSLKDL EALSEESNED GFSSQSDSNS HNSCRAKCAG DLNDMIQTTD STELIQVRKN YETIEDSEVV SVSKKVLIHD FVSALPDKYE TLVGSNASKL SGGQKQRISI ARAIIRNPKI LILDEATSSL DNKSEYLVQK TINNLKGNEN RITIIIAHRL STIRYANTIF VLSNRENGST VDVDVLGEDP TKDSNEKNEK HDKQEKGGKN SSANQKISNA GSYIIEQGTH DALMKNKNGI YYTMINNQKV SSKSSSNNDN DKDSDMKSSI YKDSERGYDP DEANGNAKNE SASAKKSEKM SDAKASNTNA GGRLAFLRNL FKRKPKAPNN LRVVYREIFS YKEDIAIIAL SIMVAGGLYP LFALLYAKYV GTLFDFANLE ANSNKYSLYI LVIAIAMFIS ETLKNYYNNV IGEKVEKTMK LRLFENILYQ EISFFDQDSH APGLLSAHIN RDVHLLKTGL VNNIVIFTHF IVLFLVSMVM SFYFCPIVAA VLTGTFFIFM RVFAIRARIA ANKDVEKKRV NQPGTAFVYN SDDEIFKDPS FLIQEAFYNM NTVIIYGLED YFCTLIEKAI DYSNKGQKRK TLINSMLWGF SQSAQLFINS FAYWFGSFLI RRGTIQVDDF MKSFFTFLFT GSYAGKLMSL KGDSENAKLS FERYYPLITR KSLIDVRDNG GIKIKNSNDI KGKIEIMDVN FRYLSRPNVP IYKDLTFSCE SKKTTAIVGE TGSGKSTVMS LLMRFYDLKN DHHIVFKNEQ TGESSKEQMQ QGDEEQNVGM KNANEFSSSK EGADGQSSTL FKNSGKILLD GVDICDYNLK DLRNLFSIVS QEPMLFNMSI YENIKFGKEN ATREDVKRAC KFAAIDEFIE SLPNQYDTNV GPYGKSLSGG QKQRIAIARA LLREPKILLL DEATSSLDSN SEKLIEKTIV DIKDKADKTI ITIAHRIASI KRSDKIVVFN NPDRTGSFVQ AQGTHEELLS VQDGVYKKYV KLAK //