ID   Q67045_9INFA            Unreviewed;       131 AA.
AC   Q67045;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   05-FEB-2008, entry version 43.
DE   Hemagglutinin (Fragment).
OS   Influenza A virus (A/Adachi/2/57(H2N2)).
OC   Viruses; ssRNA negative-strand viruses; Orthomyxoviridae;
OC   Influenzavirus A.
OX   NCBI_TaxID=223936;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=93233219; PubMed=7682624;
RA   Okuno Y., Isegawa Y., Sasao F., Ueda S.;
RT   "A common neutralizing epitope conserved between the hemagglutinins of
RT   influenza A virus H1 and H2 strains.";
RL   J. Virol. 67:2552-2558(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=81030852; PubMed=7421990; DOI=10.1038/287301a0;
RA   Gething M.-J., Bye J., Skehel J.J., Waterfield M.;
RT   "Cloning and DNA sequence of double-stranded copies of haemagglutinin
RT   genes from H2 and H3 strains elucidates antigenic shift and drift in
RT   human influenza virus.";
RL   Nature 287:301-306(1980).
CC   -!- FUNCTION: Binds to sialic acid-containing receptors on the cell
CC       surface, bringing about the attachment of the virus particle to
CC       the cell. Plays a major role in the determination of host range
CC       restriction and virulence. Class I viral fusion protein.
CC       Responsible for penetration of the virus into the cell cytoplasm
CC       by mediating the fusion of the membrane of the endocytosed virus
CC       particle with the endosomal membrane. Low pH in endosomes induce
CC       an irreversible conformational change in HA2, releasing the fusion
CC       hydrophobic peptide. Several trimers are required to form a
CC       competent fusion pore (By similarity).
CC   -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Apical cell membrane; Single-pass type I
CC       membrane protein. Note=Targeted to the apical plasma membrane in
CC       epithelial polarized cells through a signal present in the
CC       transmembrane domain. Associated with glycosphingolipid- and
CC       cholesterol-enriched detergent-resistant lipid rafts (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family.
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DR   EMBL; D13576; BAA02771.1; -; Genomic_RNA.
DR   HSSP; P03442; 1IBN.
DR   SMR; Q67045; 42-131.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:InterPro.
DR   GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR   GO; GO:0019064; P:viral envelope fusion with host membrane; IEA:InterPro.
DR   InterPro; IPR001364; Haemagglutn_influenz_HA1/HA2.
DR   InterPro; IPR000386; Haemagglutn_influenz_HA2.
DR   InterPro; IPR013829; Haemagglutn_stalk.
DR   Gene3D; G3DSA:3.90.20.10; Haemagglutn_stalk; 1.
DR   Pfam; PF00509; Hemagglutinin; 1.
DR   PRINTS; PR00329; HEMAGGLUTN12.
DR   PRINTS; PR00331; HEMAGGLUTN2.
DR   ProDom; PD000225; Hemagglutn; 1.
PE   3: Inferred from homology;
KW   Envelope protein; Fusion protein; Hemagglutinin; Membrane;
KW   Transmembrane; Virion.
FT   NON_TER       1      1
FT   NON_TER     131    131
SQ   SEQUENCE   131 AA;  14550 MW;  243DFC623E7F2952 CRC64;
     NTTLPFHNVH PLTIGECPKY VKSEKLVLAT GLRNVPQIES RGLFGAIAGF IEGGWQGMVD
     GWYGYHHSND QGSGYAADKE STQKAFDGIT NKVNSVIEKM NTQFEAVGKE FGNLERRLEN
     LNKKMEDGFL D
//