ID Q67045_9INFA PRELIMINARY; PRT; 131 AA. AC Q67045; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-NOV-1996, sequence version 1. DT 27-JUN-2006, entry version 36. DE Hemagglutinin (Fragment). OS Influenza A virus (A/Adachi/2/57(H2N2)). OC Viruses; ssRNA negative-strand viruses; Orthomyxoviridae; OC Influenzavirus A. OX NCBI_TaxID=223936; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=93233219; PubMed=7682624; RA Okuno Y., Isegawa Y., Sasao F., Ueda S.; RT "A common neutralizing epitope conserved between the hemagglutinins of RT influenza A virus H1 and H2 strains."; RL J. Virol. 67:2552-2558(1993). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=81030852; PubMed=7421990; DOI=10.1038/287301a0; RA Gething M.-J., Bye J., Skehel J.J., Waterfield M.; RT "Cloning and DNA sequence of double-stranded copies of haemagglutinin RT genes from H2 and H3 strains elucidates antigenic shift and drift in RT human influenza virus."; RL Nature 287:301-306(1980). CC -!- FUNCTION: Binds to sialic acid-containing receptors on the cell CC surface, bringing about the attachment of the virus particle to CC the cell. Plays a major role in the determination of host range CC restriction and virulence. Class I viral fusion protein. CC Responsible for penetration of the virus into the cell cytoplasm CC by mediating the fusion of the membrane of the endocytosed virus CC particle with the endosomal membrane. Low pH in endosomes induce CC an irreversible conformational change in HA2, releasing the fusion CC hydrophobic peptide. Several trimers are required to form a CC competent fusion pore (By similarity). CC -!- SUBUNIT: Homotrimer of disulfide-linked HA1-HA2 (By similarity). CC -!- SIMILARITY: Belongs to the influenza viruses hemagglutinin family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D13576; BAA02771.1; -; Genomic_RNA. DR HSSP; P03442; 1IBN. DR SMR; Q67045; 42-131. DR GO; GO:0019031; C:viral envelope; IEA. DR GO; GO:0046789; F:host cell surface receptor binding; IEA. DR GO; GO:0019064; P:viral envelope fusion with host membrane; IEA. DR InterPro; IPR008980; Capsid_haemagglutn. DR InterPro; IPR001364; Haemagglutn_influenz_HA1/HA2. DR InterPro; IPR000386; Haemagglutn_influenz_HA2. DR Pfam; PF00509; Hemagglutinin; 1. DR PRINTS; PR00329; HEMAGGLUTN12. DR PRINTS; PR00331; HEMAGGLUTN2. DR ProDom; PD000225; Hemagglutn; 1. KW Envelope protein; Hemagglutinin. FT NON_TER 1 1 FT NON_TER 131 131 SQ SEQUENCE 131 AA; 14550 MW; 243DFC623E7F2952 CRC64; NTTLPFHNVH PLTIGECPKY VKSEKLVLAT GLRNVPQIES RGLFGAIAGF IEGGWQGMVD GWYGYHHSND QGSGYAADKE STQKAFDGIT NKVNSVIEKM NTQFEAVGKE FGNLERRLEN LNKKMEDGFL D //