ID ALKB5_XENTR Reviewed; 358 AA. AC Q66JG8; DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot. DT 11-OCT-2004, sequence version 1. DT 19-OCT-2011, entry version 35. DE RecName: Full=Probable alpha-ketoglutarate-dependent dioxygenase ABH5; DE EC=1.14.11.-; DE AltName: Full=Alkylated DNA repair protein alkB homolog 5; GN Name=alkbh5; OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Amphibia; Batrachia; Anura; Mesobatrachia; Pipoidea; Pipidae; OC Xenopodinae; Xenopus; Silurana. OX NCBI_TaxID=8364; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Embryo; RG NIH - Xenopus Gene Collection (XGC) project; RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Probable dioxygenase that requires molecular oxygen, CC alpha-ketoglutarate and iron (By similarity). CC -!- COFACTOR: Binds 1 Fe(2+) ion per subunit (By similarity). CC -!- SIMILARITY: Belongs to the alkB family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BC080920; AAH80920.1; -; mRNA. DR RefSeq; NP_001008038.1; NM_001008037.1. DR UniGene; Str.66664; -. DR ProteinModelPortal; Q66JG8; -. DR GeneID; 493400; -. DR KEGG; xtr:493400; -. DR CTD; 54890; -. DR Xenbase; XB-GENE-987580; alkbh5. DR eggNOG; veNOG10808; -. DR GeneTree; ENSGT00390000009298; -. DR HOGENOM; HBG281674; -. DR HOVERGEN; HBG080833; -. DR InParanoid; Q66JG8; -. DR OrthoDB; EOG45B1FW; -. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0016706; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:InterPro. DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. DR InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase. DR Pfam; PF03171; 2OG-FeII_Oxy; 1. PE 2: Evidence at transcript level; KW Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; KW Reference proteome. FT CHAIN 1 358 Probable alpha-ketoglutarate-dependent FT dioxygenase ABH5. FT /FTId=PRO_0000239286. FT COMPBIAS 34 47 Glu-rich. FT METAL 170 170 Iron; catalytic (By similarity). FT METAL 172 172 Iron; catalytic (By similarity). FT METAL 232 232 Iron; catalytic (By similarity). SQ SEQUENCE 358 AA; 41677 MW; 69E3D4E37CC629C5 CRC64; MSATYTDLRE KLQSLYRDSP KEVRKRKQPT SDTEEEEAAS EPEEEEEARK VRSGIRQVRL FSPDECARIE AKIDEVVSRA EKGLYREHTV DRAPLRNKYF FGEGYTYGAQ LQRRGPGQER LYPKGEVDEI PAWVNELVIR RLVEHRVIPE GFVNSAVIND YQPGGCIVSH VDPIHIFERP IVSVSFFSDS ALCFGCKFQF KPIRVSEPVF FLPVQRGSVT VLSGYAADEI THCIRPQDIK ERRAVVILRK TRTEAPRLEM KSLSSSYQPE RLQGSNRQHI LKPKRSHRKA DPDAAHRPRI LEMDKEENRR SVLLPKQRRR SHFSSENYWR RSHDYVDTYT ETGEDDGSPV RKVKMRRH //