ID Q66034_9VIRU Unreviewed; 1684 AA. AC Q66034; DT 01-NOV-1996, integrated into UniProtKB/TrEMBL. DT 01-DEC-2001, sequence version 2. DT 07-APR-2021, entry version 56. DE RecName: Full=Glycoprotein G2 {ECO:0000256|ARBA:ARBA00019679}; DE AltName: Full=M polyprotein {ECO:0000256|ARBA:ARBA00014175}; OS Crimean-Congo hemorrhagic fever orthonairovirus. OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; OC Ellioviricetes; Bunyavirales; Nairoviridae; Orthonairovirus. OX NCBI_TaxID=1980519 {ECO:0000313|EMBL:AAA86616.2}; RN [1] {ECO:0000313|EMBL:AAA86616.2} RP NUCLEOTIDE SEQUENCE. RC STRAIN=10200 {ECO:0000313|EMBL:AAA86616.2}; RA Parker M.D., Glass P.J., Jennings G.B., Lofts R., Smith J.F., Miller M.M., RA Spik K.W., Schoepp R.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004614}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004614}. Host Golgi apparatus membrane CC {ECO:0000256|ARBA:ARBA00004244}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004244}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U39455; AAA86616.2; -; Genomic_RNA. DR TCDB; 1.G.20.2.1; the hantavirus gc envelope fusion glycoprotein (gc-efg) family. DR GO; GO:0044178; C:host cell Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW. DR GO; GO:0030683; P:mitigation of host immune response by virus; IEA:InterPro. DR InterPro; IPR002532; Hanta_G2. DR InterPro; IPR012487; Nairovirus_M. DR Pfam; PF01561; Hanta_G2; 1. DR Pfam; PF07948; Nairovirus_M; 1. DR PIRSF; PIRSF003962; M_poly_NairoV; 1. PE 4: Predicted; KW Host Golgi apparatus {ECO:0000256|ARBA:ARBA00022812}; KW Host membrane {ECO:0000256|ARBA:ARBA00022870}; KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Viral envelope protein {ECO:0000313|EMBL:AAA86616.2}; KW Virion {ECO:0000256|ARBA:ARBA00022844}. FT TRANSMEM 693..722 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 820..837 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 857..876 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 969..993 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1595..1620 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1082..1631 FT /note="Hanta_G2" FT /evidence="ECO:0000259|Pfam:PF01561" FT REGION 23..222 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 36..178 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 191..222 FT /note="Polar" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1684 AA; 186679 MW; C6DD80EBAD8CC3BE CRC64; MHISLMYAIL CLQLCGLGET HGSHNETRHN KTDTMTTHGD NPSSEPPVST ALSITLDPST VTPTTPASGL EGSGEVYTSP PITTGSLPLS ETTPELPVTT GTDTLSAGDV DPSTQTAGGT SAPTVRTSLP NSPSTPSTPQ DTHHPVRNLL SVTSPGPDET STPSGTGKES SATSSPHPVS NRPPTPPATA QGPTENDSHN ATEHPESLTQ SATPGLMTSP TQIVHPQSAT PITVQDTHPS PTNRSKRNLK MEIILTLSQG LKKYYGKILR LLQLTLEEDT EGLLEWCKRN LGLDCDDTFF QKRIEEFFIT GEGHFNEVLQ FRTPGTLSTT ESTPAGLPTA EPFKSYFAKG FLSIDSGYYS AKCYSGTSNS GLQLINITRH STRIVDTPGP KITNLKTINC INLKASIFKE HREVEINVLL PQVAVNLSNC HVVIKSHVCD YSLDIDGAVR LPHIYHEGVF IPGTYKIVID KKNKLNDRCT LFTDCVIKGR EVRKGQSVLR QYKTEIRIGK ASTGFRRLLS EEPSDDCVSR TQLLRTETAE IHGDNYGGPG DKITICNGST IVDQRLGSEL GCYTINRVRS FKLCENSATG KNCEIDSVPV KCRQGYCLRI TQEGRGHVKL SRGSEVVLDA CDTSCEIMIP KGTGDILVDC SGGQQHFLKD NLIDLGCPKI PLLGKMAIYI CRMSNHPKTT MAFLFWFSFG YVITCILCKA IFYLLIIVGT LGRRLKQYRE LKPQTCTICE TTPVNAIDAE MHDLNCSYNI CPYCASRLTS DGLARHVIQC PKRKEKVEET ELYLNLERIP WVVRKLLQVS ESTGVALKRS SWLIVLLVLF TVSLSPVQSA PIGQGKTIEA YRAREGYTSI CLFVLGSILF IVSCLMKGLV DSVGNSFFPG LSICKTCSIS SINGFEIESH KCYCSLFCCP YCRHCSTDKE IHKLHLSICK KRKTGSNVML AVCKLMCFRA TMEVSNRALF IRSIINTTFV LCILILAVCV VSTSAVEMEN LPAGTWEREE DLTNFCHQEC QVTETECLCP YEALVLRKPL FLDSTAKGMK NLLNSTSLET SLSIEAPWGA INVQSTYKPT VSTANIALSW SSVEHRGNKI LVSGRSESIM KLEERTGISW DLGVEDASES KLLTVSVMDL SQMYSPVFEY LSGDRQVEEW PKATCTGDCP ERCGCTSSTC LHKEWPHSRN WRCNPTWCWG VGTGCTCCGL DVKDLFTDYM FVKWKVEYIK TEAIVCVELT SQERQCSLIE AGTRFNLGPV TITLSEPRNI QQKLPPEIIT LHPRIEEGFF DLMHVQKVLS ASTVCKLQSC THGVPGDLQV YHIGNLLKGD KVNGHLIHKI EPHFNTSWMS WDGCDLDYYC NMGDWPSCTY TGVTQHNHAS FVNLLNIETD YTKNFHFHSK RVTAHGDTPQ LDLKARPTYG AGEITVLVEV ADMELHTKKI EISGLKFASL ACTGCYACSS SISCKVRIHV DEPDELTVHV KSDDPDVVAA SSSLMARKLE FGTDSTFKAF SAMPKTSLCF YIVEREHCKS CSEEDTKKCV NTKLEQPQSI LIEHKGTIIG KQNSTCTAKA SCWLESVKSF FYGLKNMLSG IFGNVFMGIF LFLAPFILLI LFFMFGWRIL FCFKCCRRTR GLFKYRHLKD DEETGYRRII EKLNNKKGKN KLLDGERLAD GRIAELFSTK THIG //