ID Q64685 PRELIMINARY; PRT; 403 AA. AC Q64685; DT 01-NOV-1996 (TREMBLREL. 01, CREATED) DT 01-NOV-1996 (TREMBLREL. 01, LAST SEQUENCE UPDATE) DT 01-FEB-1997 (TREMBLREL. 02, LAST ANNOTATION UPDATE) DE CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,6-SIALYLTRANSFERASE DE (EC 2.4.99.1) (BETA-GALACTOSIDE ALPHA-2,6-SIALYLTRANSFERASE) (ST6GALI). OS MUS MUSCULUS (MOUSE). OC EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA; OC EUTHERIA; RODENTIA. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LIVER, AND BRAIN; RA HAMAMOTO T., KAWASAKI M., KUROSAWA N., NAKAOKA T., LEE Y.-C., RA TSUJI S.; RL BIOORG. MED. CHEM. 1:141-145(1993). CC -!- CATALYTIC ACTIVITY: CMP-N-ACETYLNEURAMINATE + BETA-D-GALACTOSYL- CC 1,4-ACETYL-BETA-D-GLUCOSAMINE = CMP + ALPHA-N-ACETYLNEURAMINYL- CC 2,6-BETA-D-GALACTOSYL-1,4-N-ACETYL-BETA-D-GLUCOSAMINE. CC -!- PATHWAY: GLYCOSYLATION. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. MEMBRANE-BOUND CC FORM IN TRANS CISTERNAE OF GOLGI, SOLUBLE FORM IN BODY FLUIDS. CC -!- PTM: THE SOLUBLE FORM DERIVES FROM THE MEMBRANE FORM BY CC PROTEOLYTIC PROCESSING. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D16106; G416229; -. KW TRANSFERASE; GLYCOSYLTRANSFERASE; GLYCOPROTEIN; TRANSMEMBRANE; KW SIGNAL-ANCHOR; GOLGI STACK. FT DOMAIN 1 9 CYTOPLASMIC (POTENTIAL). FT TRANSMEM 10 26 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN). FT DOMAIN 27 403 LUMENAL, CATALYTIC (POTENTIAL). FT DOMAIN 63 413 CATALYTIC (SOLUBLE FORM) (POTENTIAL). FT CARBOHYD 146 146 POTENTIAL. FT CARBOHYD 158 158 POTENTIAL. SQ SEQUENCE 403 AA; 46407 MW; 1E8FCF16 CRC32; MIHTNLKRKF SCFVLVFLLF AIICVWKKGS DYEALTLQAK VFQMPKSQEK VAVGPAPQAV FSNSKQDPKE GVQILSYPRV TAKVKPQPSL QVWDKDSTYS KLNPRLLKIW RNYLNMNKYK VSYKGPGPGV RFSVEGLRCH LRDHVNVSMI EATDSPFNTT EWEGYLPKET FRTKAGPCTK CAVVSSAGSL KNSQLGREID NHDAVLRFNG APTDNFQQDV GTKTTIRLVN SQLVTTEKRF LKDSLYTEGI LILWDPSVYH ADIPQWYQKP DYNFFETYKS YRRLHPSQPF YILKPQMPWE LWDIIQEISP DLIQPNPPSS GMLGIIIMMT LCDQVDIYEF LPSKRKTDVC YYHQKFFDSA CTMGAYHPLL FEKNMVKHLN EGTDEDIYLF GKATLSGFRN NRC //