ID VAM2_MOUSE STANDARD; PRT; 115 AA. AC Q64357; DT 01-NOV-1997 (Rel. 35, Created) DT 01-NOV-1997 (Rel. 35, Last sequence update) DT 01-MAR-2002 (Rel. 41, Last annotation update) DE Vesicle-associated membrane protein 2 (VAMP-2) (Synaptobrevin 2). GN VAMP2 OR SYB2. OS Mus musculus (Mouse), and OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090, 10116; RN [1] RP SEQUENCE FROM N.A. RC SPECIES=Rat; RX MEDLINE=89291844; PubMed=2472388; RA Elferink L.A., Trimble W.S., Scheller R.H.; RT "Two vesicle-associated membrane protein genes are differentially RT expressed in the rat central nervous system."; RL J. Biol. Chem. 264:11061-11064(1989). RN [2] RP SEQUENCE FROM N.A. RC SPECIES=Mouse; RX MEDLINE=98104125; PubMed=9430681; RA Martin L.B., Shewan A., Millar C.A., Gould G.W., James D.E.; RT "Vesicle-associated membrane protein 2 plays a specific role in the RT insulin-dependent trafficking of the facilitative glucose transporter RT GLUT4 in 3T3-L1 adipocytes."; RL J. Biol. Chem. 273:1444-1452(1998). CC -!- FUNCTION: Involved in the targeting and/or fusion of transport CC vesicles to their target membrane. CC -!- SUBCELLULAR LOCATION: TYPE II MEMBRANE PROTEIN. NEURONAL SYNAPTIC CC VESICLES. CC -!- TISSUE SPECIFICITY: NERVOUS SYSTEM SPECIFIC. A HIGHER LEVEL CC EXPRESSION IS SEEN IN THE BRAIN AS COMPARED TO THE SPINAL CORD. CC -!- SIMILARITY: BELONGS TO THE SYNAPTOBREVIN FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M24105; AAA42321.1; -. DR EMBL; U60150; AAB03463.1; -. DR MGD; MGI:1313277; Vamp2. DR InterPro; IPR001388; Synaptobrevin. DR Pfam; PF00957; synaptobrevin; 1. DR PRINTS; PR00219; SYNAPTOBREVN. DR ProDom; PD001229; Synaptobrevin; 1. DR PROSITE; PS00417; SYNAPTOBREVIN; 1. KW Synapse; Transmembrane; Synaptosome; Multigene family; Acetylation; KW Polymorphism; Signal-anchor. FT INIT_MET 0 0 BY SIMILARITY. FT DOMAIN 1 93 CYTOPLASMIC (PROBABLE). FT TRANSMEM 94 113 SIGNAL-ANCHOR (TYPE-II MEMBRANE PROTEIN) FT (POTENTIAL). FT DOMAIN 114 115 VESICULAR (PROBABLE). FT MOD_RES 1 1 ACETYLATION (BY SIMILARITY). FT VARIANT 110 110 I -> II. FT VARIANT 111 111 V -> I. SQ SEQUENCE 115 AA; 12559 MW; EA400D6291ABF0BC CRC64; SATAATVPPA APAGEGGPPA PPPNLTSNRR LQQTQAQVDE VVDIMRVNVD KVLERDQKLS ELDDRADALQ AGASQFETSA AKLKRKYWWK NLKMMIILGV ICAIILIIII VYFST //