ID OTX2_RAT Reviewed; 70 AA. AC Q64201; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 26-JUN-2013, entry version 79. DE RecName: Full=Homeobox protein OTX2; DE AltName: Full=Orthodenticle homolog 2; DE Flags: Fragment; GN Name=Otx2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8613727; RA Robel L., Ding M., James A.J., Lin X., Simeone A., Leckman J.F., RA Vaccarino F.M.; RT "Fibroblast growth factor 2 increases Otx2 expression in precursor RT cells from mammalian telencephalon."; RL J. Neurosci. 15:7879-7891(1995). CC -!- FUNCTION: Probably plays a role in the development of the brain CC and the sense organs. Can bind to the BCD target sequence (BTS): CC 5'-TCTAATCCC-3' (By similarity). May have a role in the FGF2- CC mediated proliferation of neuronal progenitors, but not of glial CC progenitors. Interaction between basic fibroblast growth factor CC (FGF2) may be important for the regulation of neurogenesis in the CC forebrain. CC -!- SUBCELLULAR LOCATION: Nucleus (Probable). CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid CC subfamily. CC -!- SIMILARITY: Contains 1 homeobox DNA-binding domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; S81922; AAP32271.1; -; mRNA. DR IPI; IPI00231036; -. DR UniGene; Rn.35222; -. DR STRING; 10116.ENSRNOP00000018109; -. DR PhosphoSite; Q64201; -. DR UCSC; RGD:1305705; rat. DR RGD; 1305705; Otx2. DR eggNOG; NOG245767; -. DR HOGENOM; HOG000082677; -. DR InParanoid; Q64201; -. DR OrthoDB; EOG4C87T5; -. DR Genevestigator; Q64201; -. DR GermOnline; ENSRNOG00000013406; Rattus norvegicus. DR GO; GO:0005737; C:cytoplasm; IEA:Compara. DR GO; GO:0030426; C:growth cone; IEA:Compara. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0043234; C:protein complex; IEA:Compara. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara. DR GO; GO:0007411; P:axon guidance; IEA:Compara. DR GO; GO:0001708; P:cell fate specification; IEA:Compara. DR GO; GO:0048852; P:diencephalon morphogenesis; IEA:Compara. DR GO; GO:0009953; P:dorsal/ventral pattern formation; IEA:Compara. DR GO; GO:0007492; P:endoderm development; IEA:Compara. DR GO; GO:0042706; P:eye photoreceptor cell fate commitment; IEA:Compara. DR GO; GO:0042472; P:inner ear morphogenesis; IEA:Compara. DR GO; GO:0022037; P:metencephalon development; IEA:Compara. DR GO; GO:0030901; P:midbrain development; IEA:Compara. DR GO; GO:0090009; P:primitive streak formation; IEA:Compara. DR GO; GO:0006461; P:protein complex assembly; IEA:Compara. DR GO; GO:0032525; P:somite rostral/caudal axis specification; IEA:Compara. DR InterPro; IPR013851; Otx_TF_C. DR Pfam; PF03529; TF_Otx; 1. DR PROSITE; PS00027; HOMEOBOX_1; PARTIAL. DR PROSITE; PS50071; HOMEOBOX_2; PARTIAL. PE 3: Inferred from homology; KW Complete proteome; Developmental protein; DNA-binding; Homeobox; KW Nucleus; Reference proteome. FT CHAIN <1 >70 Homeobox protein OTX2. FT /FTId=PRO_0000049212. FT NON_TER 1 1 FT NON_TER 70 70 SQ SEQUENCE 70 AA; 7139 MW; 4CE56B48E00E4120 CRC64; MTYTQASGYS QGYAGSTSYF GGMDCGSYLT PMHHQLPGPG ATLSPMGTNA VTSHLNQSPA SLSTQGYGAS //